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Polrmt polymerase (RNA) mitochondrial (DNA directed) [ Mus musculus (house mouse) ]

Gene ID: 216151, updated on 6-Jun-2024

Summary

Official Symbol
Polrmtprovided by MGI
Official Full Name
polymerase (RNA) mitochondrial (DNA directed)provided by MGI
Primary source
MGI:MGI:1915843
See related
Ensembl:ENSMUSG00000020329 AllianceGenome:MGI:1915843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mtRPOL; 4932416K13; 1110018N15Rik
Summary
Enables sequence-specific DNA binding activity. Predicted to be involved in mitochondrial transcription. Located in mitochondrion. Part of protein-containing complex. Is expressed in early conceptus; limb mesenchyme; and secondary oocyte. Orthologous to human POLRMT (RNA polymerase mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 28.6), ovary adult (RPKM 26.0) and 28 other tissues See more
Orthologs
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Genomic context

See Polrmt in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79571951..79582436, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79736125..79746604, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10624 Neighboring gene basigin Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 2 Neighboring gene STARR-positive B cell enhancer ABC_E3897 Neighboring gene fibroblast growth factor 22 Neighboring gene ring finger protein 126 Neighboring gene STARR-positive B cell enhancer ABC_E899

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC118526

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA primase activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed 5'-3' RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 
enables mitochondrial promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription initiation at mitochondrial promoter ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of mitochondrial DNA-directed RNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase, mitochondrial
Names
mitochondrial DNA-directed RNA polymerase
NP_001394721.1
NP_001394722.1
NP_001394723.1
NP_001394724.1
NP_001394725.1
NP_001394726.1
NP_001394727.1
NP_001394728.1
NP_766139.2
XP_030100878.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001407792.1NP_001394721.1  DNA-directed RNA polymerase, mitochondrial isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151828
    UniProtKB/TrEMBL
    Q3V3C0
  2. NM_001407793.1NP_001394722.1  DNA-directed RNA polymerase, mitochondrial isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151828
    UniProtKB/TrEMBL
    Q3V3C0
  3. NM_001407794.1NP_001394723.1  DNA-directed RNA polymerase, mitochondrial isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151828
    UniProtKB/TrEMBL
    Q3V3C0
  4. NM_001407795.1NP_001394724.1  DNA-directed RNA polymerase, mitochondrial isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151828
    UniProtKB/TrEMBL
    E9PWD9, Q3V3C0
    Related
    ENSMUSP00000124936.2, ENSMUST00000159016.8
  5. NM_001407796.1NP_001394725.1  DNA-directed RNA polymerase, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC151828
    UniProtKB/TrEMBL
    Q3V3C0
  6. NM_001407797.1NP_001394726.1  DNA-directed RNA polymerase, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC151828
    UniProtKB/TrEMBL
    Q3V3C0
  7. NM_001407798.1NP_001394727.1  DNA-directed RNA polymerase, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC151828
    UniProtKB/TrEMBL
    Q3V3C0
  8. NM_001407799.1NP_001394728.1  DNA-directed RNA polymerase, mitochondrial isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC151828
    UniProtKB/TrEMBL
    Q3V3C0
  9. NM_172551.4NP_766139.2  DNA-directed RNA polymerase, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_766139.2

    Status: VALIDATED

    Source sequence(s)
    AC151828
    Consensus CDS
    CCDS23987.1
    UniProtKB/Swiss-Prot
    Q8BJE0, Q8BKF1
    UniProtKB/TrEMBL
    Q3U3J3, Q3V3C0
    Related
    ENSMUSP00000020580.7, ENSMUST00000020580.13
    Conserved Domains (4) summary
    PHA00452
    Location:4371207
    PHA00452; T3/T7-like RNA polymerase
    sd00004
    Location:233262
    PPR; PPR repeat [structural motif]
    pfam00940
    Location:8021206
    RNA_pol; DNA-dependent RNA polymerase
    pfam14700
    Location:374674
    RPOL_N; DNA-directed RNA polymerase N-terminal

RNA

  1. NR_176423.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC151828
    Related
    ENSMUST00000162694.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79571951..79582436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245018.2XP_030100878.1  DNA-directed RNA polymerase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q3V3C0
    Conserved Domains (3) summary
    sd00004
    Location:233262
    PPR; PPR repeat [structural motif]
    pfam00940
    Location:8021236
    RNA_pol; DNA-dependent RNA polymerase
    pfam14700
    Location:375675
    RPOL_N; DNA-directed RNA polymerase N-terminal

RNA

  1. XR_003948668.2 RNA Sequence

    Related
    ENSMUST00000159082.8