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Mcm3ap minichromosome maintenance complex component 3 associated protein [ Mus musculus (house mouse) ]

Gene ID: 54387, updated on 18-Apr-2024

Summary

Official Symbol
Mcm3approvided by MGI
Official Full Name
minichromosome maintenance complex component 3 associated proteinprovided by MGI
Primary source
MGI:MGI:1930089
See related
Ensembl:ENSMUSG00000001150 AllianceGenome:MGI:1930089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GANP
Summary
Predicted to enable H3 histone acetyltransferase activity; chromatin binding activity; and histone binding activity. Predicted to be involved in nucleosome organization; poly(A)+ mRNA export from nucleus; and somatic hypermutation of immunoglobulin genes. Predicted to act upstream of or within immune system process; mRNA transport; and protein transport. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human MCM3AP (minichromosome maintenance complex component 3 associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.2), CNS E14 (RPKM 10.8) and 28 other tissues See more
Orthologs
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Genomic context

Location:
10 C1; 10 38.88 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76304736..76351693)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76468902..76515859)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene pericentrin (kendrin) Neighboring gene STARR-seq mESC enhancer starr_27179 Neighboring gene RIKEN cDNA 2610028H24 gene Neighboring gene STARR-seq mESC enhancer starr_27180 Neighboring gene STARR-seq mESC enhancer starr_27181 Neighboring gene predicted gene 9744 Neighboring gene STARR-seq mESC enhancer starr_27182 Neighboring gene ybeY metallopeptidase Neighboring gene STARR-positive B cell enhancer ABC_E6874 Neighboring gene RIKEN cDNA 4930483K19 gene Neighboring gene lanosterol synthase Neighboring gene spermatogenesis and centriole associated 1 like Neighboring gene predicted gene 15343

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0572

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H3 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in poly(A)+ mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in somatic hypermutation of immunoglobulin genes ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore nuclear basket ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription export complex 2 IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription export complex 2 ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
germinal-center associated nuclear protein
Names
80 kDa MCM3-associated protein
GC-associated DNA primase
minichromosome maintenance deficient 3-associated protein
nuclear protein GANP
NP_062307.2
XP_006513957.1
XP_036011786.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019434.3NP_062307.2  germinal-center associated nuclear protein

    See identical proteins and their annotated locations for NP_062307.2

    Status: VALIDATED

    Source sequence(s)
    BC052452, BC067414, BY004673
    Consensus CDS
    CCDS23947.1
    UniProtKB/Swiss-Prot
    Q7TS87, Q9WUU9
    UniProtKB/TrEMBL
    Q80TX5
    Related
    ENSMUSP00000125960.2, ENSMUST00000170795.3
    Conserved Domains (6) summary
    cd12443
    Location:429500
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:679903
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam13634
    Location:36117
    Nucleoporin_FG; Nucleoporin FG repeat region
    pfam16766
    Location:11571226
    CID_GANP; Binding region of GANP to ENY2
    pfam16768
    Location:3286
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    pfam16769
    Location:12541967
    MCM3AP_GANP; MCM3AP domain of GANP

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    76304736..76351693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155893.1XP_036011786.1  germinal-center associated nuclear protein isoform X1

    UniProtKB/TrEMBL
    Q8C777
    Conserved Domains (3) summary
    pfam03399
    Location:1229
    SAC3_GANP; SAC3/GANP family
    pfam16766
    Location:464533
    CID_GANP; Binding region of GANP to ENY2
    pfam16769
    Location:5611274
    MCM3AP_GANP; MCM3AP domain of GANP
  2. XM_006513894.3XP_006513957.1  germinal-center associated nuclear protein isoform X1

    UniProtKB/TrEMBL
    Q8C777
    Conserved Domains (3) summary
    pfam03399
    Location:1229
    SAC3_GANP; SAC3/GANP family
    pfam16766
    Location:464533
    CID_GANP; Binding region of GANP to ENY2
    pfam16769
    Location:5611274
    MCM3AP_GANP; MCM3AP domain of GANP