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MCM3AP minichromosome maintenance complex component 3 associated protein [ Homo sapiens (human) ]

Gene ID: 8888, updated on 8-Nov-2020

Summary

Official Symbol
MCM3APprovided by HGNC
Official Full Name
minichromosome maintenance complex component 3 associated proteinprovided by HGNC
Primary source
HGNC:HGNC:6946
See related
Ensembl:ENSG00000160294 MIM:603294
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GANP; SAC3; MAP80; PNRIID
Summary
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in lymph node (RPKM 12.6), spleen (RPKM 12.4) and 25 other tissues See more
Orthologs

Genomic context

See MCM3AP in Genome Data Viewer
Location:
21q22.3
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (46235130..46286297, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (47655047..47706211, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 159 Neighboring gene lanosterol synthase Neighboring gene Sharpr-MPRA regulatory region 3947 Neighboring gene MCM3AP antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1466 Neighboring gene ybeY metalloendoribonuclease Neighboring gene chromosome 21 open reading frame 58

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of minichromosome maintenance complex component 3 associated protein (MCM3AP) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Encapsidation of GANP into virions requires the CA region of HIV-1 Gag and GANP and is associated with HIV-1 genomic RNA PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44336, FLJ45306, KIAA0572

Gene Ontology Provided by GOA

Function Evidence Code Pubs
H3 histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
histone H3 acetylation IEA
Inferred from Electronic Annotation
more info
 
mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome organization IDA
Inferred from Direct Assay
more info
PubMed 
poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic hypermutation of immunoglobulin genes IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol HDA PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription export complex 2 IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription export complex 2 IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
germinal-center associated nuclear protein
Names
80 kDa MCM3-associated protein
MCM3 acetylating protein
MCM3 acetyltransferase
MCM3 import protein
MCM3 minichromosome maintenance deficient 3 associated protein
germinal center-associated nuclear protein
germinal-centre associated nuclear protein
NP_003897.2
XP_005261260.1
XP_005261261.1
XP_005261262.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033881.1 RefSeqGene

    Range
    4712..55190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003906.5NP_003897.2  germinal-center associated nuclear protein

    See identical proteins and their annotated locations for NP_003897.2

    Status: REVIEWED

    Source sequence(s)
    AA659734, AJ010089, AL079407, AP000471, BC104958
    Consensus CDS
    CCDS13734.1
    UniProtKB/Swiss-Prot
    O60318
    Related
    ENSP00000291688.1, ENST00000291688.6
    Conserved Domains (5) summary
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam16766
    Location:11641234
    CID_GANP; Binding region of GANP to ENY2
    pfam16768
    Location:2291
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    pfam16769
    Location:12621976
    MCM3AP_GANP; MCM3AP domain of GANP

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    46235130..46286297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261203.4XP_005261260.1  germinal-center associated nuclear protein isoform X1

    See identical proteins and their annotated locations for XP_005261260.1

    UniProtKB/Swiss-Prot
    O60318
    Conserved Domains (5) summary
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam16766
    Location:11641234
    CID_GANP; Binding region of GANP to ENY2
    pfam16768
    Location:2291
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    pfam16769
    Location:12621976
    MCM3AP_GANP; MCM3AP domain of GANP
  2. XM_005261205.4XP_005261262.1  germinal-center associated nuclear protein isoform X1

    See identical proteins and their annotated locations for XP_005261262.1

    UniProtKB/Swiss-Prot
    O60318
    Related
    ENSP00000380820.1, ENST00000397708.1
    Conserved Domains (5) summary
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam16766
    Location:11641234
    CID_GANP; Binding region of GANP to ENY2
    pfam16768
    Location:2291
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    pfam16769
    Location:12621976
    MCM3AP_GANP; MCM3AP domain of GANP
  3. XM_005261204.5XP_005261261.1  germinal-center associated nuclear protein isoform X1

    See identical proteins and their annotated locations for XP_005261261.1

    UniProtKB/Swiss-Prot
    O60318
    Conserved Domains (5) summary
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam16766
    Location:11641234
    CID_GANP; Binding region of GANP to ENY2
    pfam16768
    Location:2291
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    pfam16769
    Location:12621976
    MCM3AP_GANP; MCM3AP domain of GANP
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