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Slc23a2 solute carrier family 23 (nucleobase transporters), member 2 [ Mus musculus (house mouse) ]

Gene ID: 54338, updated on 22-Feb-2024

Summary

Official Symbol
Slc23a2provided by MGI
Official Full Name
solute carrier family 23 (nucleobase transporters), member 2provided by MGI
Primary source
MGI:MGI:1859682
See related
Ensembl:ENSMUSG00000027340 AllianceGenome:MGI:1859682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NBTL1; SVCT2; YSPL2; YSPL3; Slc23a1; mKIAA0238
Summary
Enables L-ascorbate:sodium symporter activity and L-ascorbic acid transmembrane transporter activity. Involved in L-ascorbic acid transmembrane transport. Located in basal plasma membrane and cytoplasm. Is expressed in adrenal gland; central nervous system; metanephros; and retina. Orthologous to human SLC23A2 (solute carrier family 23 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 24.3), cortex adult (RPKM 20.2) and 26 other tissues See more
Orthologs
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Genomic context

See Slc23a2 in Genome Data Viewer
Location:
2 F2; 2 64.15 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131894416..131987287, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132052496..132145320, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:131844916-131845217 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131846634-131846817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131855025-131855212 Neighboring gene STARR-positive B cell enhancer ABC_E9533 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131861333-131861539 Neighboring gene predicted gene, 31179 Neighboring gene STARR-positive B cell enhancer ABC_E5986 Neighboring gene STARR-positive B cell enhancer ABC_E10148 Neighboring gene STARR-positive B cell enhancer ABC_E8794 Neighboring gene STARR-positive B cell enhancer ABC_E8795 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05728 Neighboring gene predicted gene 14051 Neighboring gene STARR-seq mESC enhancer starr_05733 Neighboring gene STARR-seq mESC enhancer starr_05734 Neighboring gene STARR-seq mESC enhancer starr_05736 Neighboring gene predicted gene, 29720 Neighboring gene STARR-positive B cell enhancer ABC_E10149 Neighboring gene transmembrane protein 230

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-ascorbate:sodium symporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables L-ascorbate:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables L-ascorbic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-ascorbic acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables L-ascorbic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
solute carrier family 23 member 2
Names
Na(+)/L-ascorbic acid transporter 2
SVCT-2
mSVCT2
sodium-dependent vitamin C transporter 2
solute carrier family 23 (nucleobase transporters), member 1
yolk sac permease-like molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355430.2NP_001342359.1  solute carrier family 23 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AL831706, AL929513
    Consensus CDS
    CCDS16769.1
    UniProtKB/Swiss-Prot
    Q80Y23, Q8C327, Q9EPR4, Q9JM78
    Conserved Domains (1) summary
    pfam00860
    Location:103529
    Xan_ur_permease; Permease family
  2. NM_001355431.2NP_001342360.1  solute carrier family 23 member 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL831706
    Related
    ENSMUST00000127724.8
    Conserved Domains (1) summary
    cl23746
    Location:86156
    HCO3_cotransp; HCO3- transporter family
  3. NM_001421503.1NP_001408432.1  solute carrier family 23 member 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL831706, AL929513
    UniProtKB/Swiss-Prot
    Q80Y23, Q8C327, Q9EPR4, Q9JM78
  4. NM_001421504.1NP_001408433.1  solute carrier family 23 member 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL831706, AL929513
  5. NM_001421505.1NP_001408434.1  solute carrier family 23 member 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL831706
  6. NM_001421507.1NP_001408436.1  solute carrier family 23 member 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL831706
  7. NM_001421508.1NP_001408437.1  solute carrier family 23 member 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL831706
  8. NM_018824.3NP_061294.2  solute carrier family 23 member 2 isoform a

    See identical proteins and their annotated locations for NP_061294.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AL831706, AL929513
    Consensus CDS
    CCDS16769.1
    UniProtKB/Swiss-Prot
    Q80Y23, Q8C327, Q9EPR4, Q9JM78
    Related
    ENSMUSP00000028815.9, ENSMUST00000028815.15
    Conserved Domains (1) summary
    pfam00860
    Location:103529
    Xan_ur_permease; Permease family

RNA

  1. NR_185307.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831706, AL929513

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    131894416..131987287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239698.4XP_011238000.1  solute carrier family 23 member 2 isoform X1

    See identical proteins and their annotated locations for XP_011238000.1

    UniProtKB/Swiss-Prot
    Q80Y23, Q8C327, Q9EPR4, Q9JM78
    Conserved Domains (1) summary
    pfam00860
    Location:103529
    Xan_ur_permease; Permease family
  2. XM_006499907.5XP_006499970.1  solute carrier family 23 member 2 isoform X1

    See identical proteins and their annotated locations for XP_006499970.1

    UniProtKB/Swiss-Prot
    Q80Y23, Q8C327, Q9EPR4, Q9JM78
    Conserved Domains (1) summary
    pfam00860
    Location:103529
    Xan_ur_permease; Permease family
  3. XM_030251882.2XP_030107742.1  solute carrier family 23 member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q80Y23, Q8C327, Q9EPR4, Q9JM78
    Conserved Domains (1) summary
    pfam00860
    Location:103529
    Xan_ur_permease; Permease family