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Slc23a2 solute carrier family 23 (nucleobase transporters), member 2 [ Mus musculus (house mouse) ]

Gene ID: 54338, updated on 2-Nov-2024

Summary

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Official Symbol
Slc23a2provided by MGI
Official Full Name
solute carrier family 23 (nucleobase transporters), member 2provided by MGI
Primary source
MGI:MGI:1859682
See related
Ensembl:ENSMUSG00000027340 AllianceGenome:MGI:1859682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NBTL1; SVCT2; YSPL2; YSPL3; Slc23a1; mKIAA0238
Summary
Enables L-ascorbate:sodium symporter activity and L-ascorbic acid transmembrane transporter activity. Involved in L-ascorbic acid transmembrane transport. Acts upstream of or within blood circulation. Located in basal plasma membrane and cytoplasm. Is expressed in adrenal gland; central nervous system; liver; metanephros; and retina. Orthologous to human SLC23A2 (solute carrier family 23 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 24.3), cortex adult (RPKM 20.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Slc23a2 in Genome Data Viewer
Location:
2 F2; 2 64.15 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131894416..131987287, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132052496..132145320, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:131844916-131845217 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131846634-131846817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131855025-131855212 Neighboring gene STARR-positive B cell enhancer ABC_E9533 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131861333-131861539 Neighboring gene predicted gene, 31179 Neighboring gene STARR-positive B cell enhancer ABC_E5986 Neighboring gene STARR-positive B cell enhancer ABC_E10148 Neighboring gene STARR-positive B cell enhancer ABC_E8794 Neighboring gene STARR-positive B cell enhancer ABC_E8795 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05728 Neighboring gene predicted gene 14051 Neighboring gene STARR-seq mESC enhancer starr_05733 Neighboring gene STARR-seq mESC enhancer starr_05734 Neighboring gene STARR-seq mESC enhancer starr_05736 Neighboring gene predicted gene, 29720 Neighboring gene STARR-positive B cell enhancer ABC_E10149 Neighboring gene transmembrane protein 230

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dexamethasone induces sodium-dependant vitamin C transporter in a mouse osteoblastic cell line MC3T3-E1. Fujita I, et al. Br J Nutr, 2001 Aug. PMID 11502226
  2. Sodium-dependent vitamin C transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system. Gess B, et al. J Neurosci, 2011 Nov 23. PMID 22114285, Free PMC Article
  3. Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung. Harrison FE, et al. PLoS One, 2012. PMID 22558179, Free PMC Article
  4. Sodium-dependent vitamin C transporter 2 (SVCT2) expression and activity in brain capillary endothelial cells after transient ischemia in mice. Gess B, et al. PLoS One, 2011 Feb 11. PMID 21347255, Free PMC Article
  5. Selective macrophage ascorbate deficiency suppresses early atherosclerosis. Babaev VR, et al. Free Radic Biol Med, 2011 Jan 1. PMID 20974251, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modulation of microglia activation by the ascorbic acid transporter SVCT2.
    Title: Modulation of microglia activation by the ascorbic acid transporter SVCT2.
  2. Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages.
    Title: Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages.
  3. Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model.
    Title: Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model.
  4. SVCT2/SLC23A2 is a sodium-dependent urate transporter: functional properties and practical application.
    Title: SVCT2/SLC23A2 is a sodium-dependent urate transporter: functional properties and practical application.
  5. Calsyntenin-3 interacts with the sodium-dependent vitamin C transporter-2 to regulate vitamin C uptake.
    Title: Calsyntenin-3 interacts with the sodium-dependent vitamin C transporter-2 to regulate vitamin C uptake.
  6. Sodium vitamin C transporter 2 orchestrates lactate metabolism in mouse Sertoli cells.
    Title: Sodium vitamin C transporter 2 orchestrates lactate metabolism in mouse Sertoli cells.
  7. Impaired intracellular trafficking of sodium-dependent vitamin C transporter 2 contributes to the redox imbalance in Huntington's disease.
    Title: Impaired intracellular trafficking of sodium-dependent vitamin C transporter 2 contributes to the redox imbalance in Huntington's disease.
  8. SVCT2-Dependent plasma and mitochondrial membrane transport of ascorbic acid in differentiating myoblasts.
    Title: SVCT2-Dependent plasma and mitochondrial membrane transport of ascorbic acid in differentiating myoblasts.
  9. Basal Sodium-Dependent Vitamin C Transporter 2 polarization in choroid plexus explant cells in normal or scorbutic conditions.
    Title: Basal Sodium-Dependent Vitamin C Transporter 2 polarization in choroid plexus explant cells in normal or scorbutic conditions.
  10. Alternative pathways and key genes that connect Tet2, Bcl2, and Slc23a2 for their therapeutic applications with vitamin C were identified.
    Title: Association of Leukemia Target Genes Tet2, Bcl2, and Slc23a2 in Vitamin C Pathways.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-ascorbate:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-ascorbate:sodium symporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-ascorbate:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables L-ascorbic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-ascorbic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-ascorbic acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-ascorbic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-ascorbic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-ascorbic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-ascorbic acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-ascorbic acid transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-ascorbic acid transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-ascorbic acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blood circulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to ethanol IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite extension IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 23 member 2
Names
Na(+)/L-ascorbic acid transporter 2
SVCT-2
mSVCT2
sodium-dependent vitamin C transporter 2
solute carrier family 23 (nucleobase transporters), member 1
yolk sac permease-like molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355430.2 → NP_001342359.1  solute carrier family 23 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AL831706, AL929513
    Consensus CDS
    CCDS16769.1
    UniProtKB/Swiss-Prot
    Q80Y23, Q8C327, Q9EPR4, Q9JM78
    Conserved Domains (1) summary
    pfam00860
    Location:103 → 529
    Xan_ur_permease; Permease family

  2. NM_001355431.2 → NP_001342360.1  solute carrier family 23 member 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL831706
    Related
    ENSMUST00000127724.8
    Conserved Domains (1) summary
    cl23746
    Location:86 → 156
    HCO3_cotransp; HCO3- transporter family

  3. NM_001421503.1 → NP_001408432.1  solute carrier family 23 member 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL831706, AL929513
    UniProtKB/Swiss-Prot
    Q80Y23, Q8C327, Q9EPR4, Q9JM78

  4. NM_001421504.1 → NP_001408433.1  solute carrier family 23 member 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL831706, AL929513

  5. NM_001421505.1 → NP_001408434.1  solute carrier family 23 member 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL831706

  6. NM_001421507.1 → NP_001408436.1  solute carrier family 23 member 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL831706

  7. NM_001421508.1 → NP_001408437.1  solute carrier family 23 member 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL831706

  8. NM_018824.3 → NP_061294.2  solute carrier family 23 member 2 isoform a

    See identical proteins and their annotated locations for NP_061294.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AL831706, AL929513
    Consensus CDS
    CCDS16769.1
    UniProtKB/Swiss-Prot
    Q80Y23, Q8C327, Q9EPR4, Q9JM78
    Related
    ENSMUSP00000028815.9, ENSMUST00000028815.15
    Conserved Domains (1) summary
    pfam00860
    Location:103 → 529
    Xan_ur_permease; Permease family

RNA

  1. NR_185307.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831706, AL929513

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    131894416..131987287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239698.4 → XP_011238000.1  solute carrier family 23 member 2 isoform X1

    See identical proteins and their annotated locations for XP_011238000.1

    UniProtKB/Swiss-Prot
    Q80Y23, Q8C327, Q9EPR4, Q9JM78
    Conserved Domains (1) summary
    pfam00860
    Location:103 → 529
    Xan_ur_permease; Permease family

  2. XM_006499907.5 → XP_006499970.1  solute carrier family 23 member 2 isoform X1

    See identical proteins and their annotated locations for XP_006499970.1

    UniProtKB/Swiss-Prot
    Q80Y23, Q8C327, Q9EPR4, Q9JM78
    Conserved Domains (1) summary
    pfam00860
    Location:103 → 529
    Xan_ur_permease; Permease family

  3. XM_030251882.2 → XP_030107742.1  solute carrier family 23 member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q80Y23, Q8C327, Q9EPR4, Q9JM78
    Conserved Domains (1) summary
    pfam00860
    Location:103 → 529
    Xan_ur_permease; Permease family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPR4.2 GenPept UniProtKB/Swiss-Prot:Q9EPR4

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