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SLC23A2 solute carrier family 23 member 2 [ Homo sapiens (human) ]

Gene ID: 9962, updated on 18-Aug-2020

Summary

Official Symbol
SLC23A2provided by HGNC
Official Full Name
solute carrier family 23 member 2provided by HGNC
Primary source
HGNC:HGNC:10973
See related
Ensembl:ENSG00000089057 MIM:603791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NBTL1; SVCT2; YSPL2; SLC23A1
Summary
The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]
Expression
Broad expression in adrenal (RPKM 40.7), brain (RPKM 20.8) and 23 other tissues See more
Orthologs

Genomic context

See SLC23A2 in Genome Data Viewer
Location:
20p13
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (4852358..5010313, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (4833002..4990939, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372511 Neighboring gene Ras association domain family member 2 Neighboring gene uncharacterized LOC107985392 Neighboring gene Sharpr-MPRA regulatory region 14391 Neighboring gene SLC23A2 promoter P2 Neighboring gene SLC23A2 promoter P1 Neighboring gene ribosomal protein S21 pseudogene 7 Neighboring gene transmembrane protein 230 Neighboring gene RNA, 5S ribosomal pseudogene 474

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0238

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-ascorbic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleobase transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
sodium-dependent L-ascorbate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
L-ascorbic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-ascorbic acid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
L-ascorbic acid metabolic process TAS
Traceable Author Statement
more info
 
L-ascorbic acid transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
nucleobase transport TAS
Traceable Author Statement
more info
PubMed 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
transepithelial L-ascorbic acid transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IC
Inferred by Curator
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 23 member 2
Names
Na(+)/L-ascorbic acid transporter 2
nucleobase transporter-like 1 protein
sodium-dependent vitamin C transporter-2
solute carrier family 23 (ascorbic acid transporter), member 2
solute carrier family 23 (nucleobase transporters), member 1
solute carrier family 23 (nucleobase transporters), member 2
testicular secretory protein Li 48
yolk sac permease-like molecule 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029959.2 RefSeqGene

    Range
    13784..162936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005116.6NP_005107.4  solute carrier family 23 member 2

    See identical proteins and their annotated locations for NP_005107.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) occurs more frequently. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AI742576, AL121890, BC013112, D87075
    Consensus CDS
    CCDS13085.1
    UniProtKB/Swiss-Prot
    Q9UGH3
    UniProtKB/TrEMBL
    A0A140VK48
    Related
    ENSP00000344322.1, ENST00000338244.6
    Conserved Domains (1) summary
    pfam00860
    Location:103531
    Xan_ur_permease; Permease family
  2. NM_203327.2NP_976072.1  solute carrier family 23 member 2

    See identical proteins and their annotated locations for NP_976072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AF164142, AI742576, AL121890, BC013112, D87075
    Consensus CDS
    CCDS13085.1
    UniProtKB/Swiss-Prot
    Q9UGH3
    UniProtKB/TrEMBL
    A0A140VK48
    Related
    ENSP00000368637.1, ENST00000379333.5
    Conserved Domains (1) summary
    pfam00860
    Location:103531
    Xan_ur_permease; Permease family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    4852358..5010313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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