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GNG2 G protein subunit gamma 2 [ Homo sapiens (human) ]

Gene ID: 54331, updated on 3-May-2020

Summary

Official Symbol
GNG2provided by HGNC
Official Full Name
G protein subunit gamma 2provided by HGNC
Primary source
HGNC:HGNC:4404
See related
Ensembl:ENSG00000186469 MIM:606981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
Expression
Broad expression in brain (RPKM 43.3), spleen (RPKM 22.6) and 23 other tissues See more
Orthologs

Genomic context

See GNG2 in Genome Data Viewer
Location:
14q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (51847131..51969800)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (52327022..52436518)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927598 Neighboring gene olfactory receptor family 7 subfamily E member 106 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 159 pseudogene Neighboring gene uncharacterized LOC102723604 Neighboring gene uncharacterized LOC105370497 Neighboring gene Sharpr-MPRA regulatory region 5932 Neighboring gene RNA transcription, translation and transport factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.
NHGRI GWA Catalog
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein beta-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating dopamine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular response to catecholamine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to prostaglandin E stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
protein folding TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
G-protein beta/gamma-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heterotrimeric G-protein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Names
g gamma-I
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein gamma 2
guanine nucleotide-binding protein G(I)/G(O) gamma-2 subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243773.2NP_001230702.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

    See identical proteins and their annotated locations for NP_001230702.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL358333, BQ025819, DA226565, DC318652
    Consensus CDS
    CCDS32082.1
    UniProtKB/Swiss-Prot
    P59768
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  2. NM_001243774.2NP_001230703.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

    See identical proteins and their annotated locations for NP_001230703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL358333, BE245271, BQ025819, DC318652
    Consensus CDS
    CCDS32082.1
    UniProtKB/Swiss-Prot
    P59768
    Related
    ENSP00000334448.4, ENST00000335281.8
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  3. NM_053064.5NP_444292.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

    See identical proteins and their annotated locations for NP_444292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL358333, BQ025819, DA785895, DC318652
    Consensus CDS
    CCDS32082.1
    UniProtKB/Swiss-Prot
    P59768
    Related
    ENSP00000451231.1, ENST00000556766.5
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    51847131..51969800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720173.2XP_006720236.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    See identical proteins and their annotated locations for XP_006720236.1

    UniProtKB/Swiss-Prot
    P59768
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  2. XM_024449633.1XP_024305401.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  3. XM_017021377.1XP_016876866.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    UniProtKB/Swiss-Prot
    P59768
    Related
    ENSP00000484021.1, ENST00000615906.4
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  4. XM_024449634.1XP_024305402.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  5. XM_024449632.1XP_024305400.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  6. XM_011536846.2XP_011535148.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    See identical proteins and their annotated locations for XP_011535148.1

    UniProtKB/Swiss-Prot
    P59768
    Related
    ENSP00000451576.1, ENST00000556752.2
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  7. XM_024449630.1XP_024305398.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  8. XM_017021376.2XP_016876865.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    UniProtKB/Swiss-Prot
    P59768
    Related
    ENSP00000451102.1, ENST00000555472.5
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  9. XM_024449631.1XP_024305399.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  10. XM_024449629.1XP_024305397.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

    Conserved Domains (1) summary
    smart00224
    Location:1981
    GGL; G protein gamma subunit-like motifs
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