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GNG2 G protein subunit gamma 2 [ Homo sapiens (human) ]

Gene ID: 54331, updated on 4-Dec-2022

Summary

Official Symbol
GNG2provided by HGNC
Official Full Name
G protein subunit gamma 2provided by HGNC
Primary source
HGNC:HGNC:4404
See related
Ensembl:ENSG00000186469 MIM:606981; AllianceGenome:HGNC:4404
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HG3F1
Summary
This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
Expression
Broad expression in brain (RPKM 43.3), spleen (RPKM 22.6) and 23 other tissues See more
Orthologs
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Genomic context

See GNG2 in Genome Data Viewer
Location:
14q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (51826174..51969795)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (46033129..46176839)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (52292892..52436513)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927598 Neighboring gene olfactory receptor family 7 subfamily E member 106 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 159 pseudogene Neighboring gene uncharacterized LOC102723604 Neighboring gene uncharacterized LOC105370497 Neighboring gene Sharpr-MPRA regulatory region 5932 Neighboring gene RNA transcription, translation and transport factor Neighboring gene Sharpr-MPRA regulatory region 12958 Neighboring gene nidogen 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.
EBI GWAS Catalog
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-protein beta-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenylate cyclase-activating dopamine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to catecholamine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to prostaglandin E stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of heterotrimeric G-protein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Names
g gamma-I
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein gamma 2
guanine nucleotide-binding protein G(I)/G(O) gamma-2 subunit
heterotrimeric guanine nucleotide-binding protein 3F1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243773.2NP_001230702.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

    See identical proteins and their annotated locations for NP_001230702.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL358333, BQ025819, DA226565, DC318652
    Consensus CDS
    CCDS32082.1
    UniProtKB/Swiss-Prot
    P59768, Q6P9A9
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  2. NM_001243774.2NP_001230703.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

    See identical proteins and their annotated locations for NP_001230703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL358333, BE245271, BQ025819, DC318652
    Consensus CDS
    CCDS32082.1
    UniProtKB/Swiss-Prot
    P59768, Q6P9A9
    Related
    ENSP00000334448.4, ENST00000335281.8
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  3. NM_001389707.1NP_001376636.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL079307, AL358333
    Consensus CDS
    CCDS32082.1
    UniProtKB/Swiss-Prot
    Q6P9A9
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  4. NM_001389708.1NP_001376637.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL079307, AL358333
    Consensus CDS
    CCDS32082.1
    UniProtKB/Swiss-Prot
    Q6P9A9
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  5. NM_001389709.1NP_001376638.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL358333
    Consensus CDS
    CCDS32082.1
    UniProtKB/Swiss-Prot
    Q6P9A9
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  6. NM_001389710.1NP_001376639.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL358333
    Consensus CDS
    CCDS32082.1
    UniProtKB/Swiss-Prot
    Q6P9A9
    Related
    ENSP00000452014.1, ENST00000554736.5
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  7. NM_053064.5NP_444292.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

    See identical proteins and their annotated locations for NP_444292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL358333, BQ025819, DA785895, DC318652
    Consensus CDS
    CCDS32082.1
    UniProtKB/Swiss-Prot
    P59768, Q6P9A9
    Related
    ENSP00000451231.1, ENST00000556766.6
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    51826174..51969795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431486.1XP_047287442.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    UniProtKB/Swiss-Prot
    Q6P9A9
  2. XM_017021377.2XP_016876866.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    UniProtKB/Swiss-Prot
    P59768, Q6P9A9
    Related
    ENSP00000484021.1, ENST00000615906.4
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  3. XM_024449633.2XP_024305401.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    UniProtKB/Swiss-Prot
    Q6P9A9
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  4. XM_024449634.2XP_024305402.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    UniProtKB/Swiss-Prot
    Q6P9A9
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  5. XM_047431490.1XP_047287446.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    UniProtKB/Swiss-Prot
    Q6P9A9
  6. XM_047431488.1XP_047287444.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    UniProtKB/Swiss-Prot
    Q6P9A9
  7. XM_047431487.1XP_047287443.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    UniProtKB/Swiss-Prot
    Q6P9A9
  8. XM_047431485.1XP_047287441.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    46033129..46176839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)