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Gng2 guanine nucleotide binding protein (G protein), gamma 2 [ Mus musculus (house mouse) ]

Gene ID: 14702, updated on 18-Sep-2024

Summary

Official Symbol
Gng2provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), gamma 2provided by MGI
Primary source
MGI:MGI:102705
See related
Ensembl:ENSMUSG00000043004 AllianceGenome:MGI:102705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg3f1
Summary
Predicted to enable G-protein beta-subunit binding activity and GTPase activity. Acts upstream of or within G protein-coupled receptor signaling pathway and cell population proliferation. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in early conceptus; intestine; nervous system; neural retina; and oocyte. Orthologous to human GNG2 (G protein subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 89.6), whole brain E14.5 (RPKM 69.3) and 6 other tissues See more
Orthologs
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Genomic context

See Gng2 in Genome Data Viewer
Location:
14 A3; 14 11.17 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (19922626..20027893, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (19872558..19977825, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nidogen 2 Neighboring gene STARR-positive B cell enhancer ABC_E9891 Neighboring gene DNA segment, Chr 14, ERATO Doi 670, expressed Neighboring gene RNA transcription, translation and transport factor Neighboring gene STARR-seq mESC enhancer starr_36086 Neighboring gene STARR-seq mESC enhancer starr_36089 Neighboring gene VISTA enhancer mm1498 Neighboring gene STARR-seq mESC enhancer starr_36096 Neighboring gene STARR-seq mESC enhancer starr_36097 Neighboring gene STARR-seq mESC enhancer starr_36099 Neighboring gene SAYSVFN motif domain containing 1 Neighboring gene predicted gene, 41104

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • 1110003P13Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-protein beta-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables G-protein beta-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Names
g gamma-I
heterotrimeric guanine nucleotide-binding protein 3f1
NP_001033726.1
NP_001272837.1
NP_001272838.1
NP_001272839.1
NP_001272840.1
NP_001411396.1
NP_001411397.1
NP_034445.1
XP_030103512.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038637.1NP_001033726.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

    See identical proteins and their annotated locations for NP_001033726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AC130831, AK158697, AK160396, BY245532
    Consensus CDS
    CCDS26840.1
    UniProtKB/Swiss-Prot
    P63213, Q3TYE8
    Related
    ENSMUSP00000125000.2, ENSMUST00000159073.8
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  2. NM_001285908.1NP_001272837.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

    See identical proteins and their annotated locations for NP_001272837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AC130831, BY245532, W48309
    Consensus CDS
    CCDS26840.1
    UniProtKB/Swiss-Prot
    P63213, Q3TYE8
    Related
    ENSMUSP00000124153.2, ENSMUST00000162425.8
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  3. NM_001285909.1NP_001272838.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

    See identical proteins and their annotated locations for NP_001272838.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AC130831, BY245532, CA324196
    Consensus CDS
    CCDS26840.1
    UniProtKB/Swiss-Prot
    P63213, Q3TYE8
    Related
    ENSMUSP00000055256.8, ENSMUST00000055100.14
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  4. NM_001285910.1NP_001272839.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

    See identical proteins and their annotated locations for NP_001272839.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AC130831, AK158697, BY108799
    Consensus CDS
    CCDS26840.1
    UniProtKB/Swiss-Prot
    P63213, Q3TYE8
    Related
    ENSMUSP00000125141.2, ENSMUST00000159028.8
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  5. NM_001285911.1NP_001272840.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

    See identical proteins and their annotated locations for NP_001272840.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AC130831, W48309
    Consensus CDS
    CCDS26840.1
    UniProtKB/Swiss-Prot
    P63213, Q3TYE8
    Related
    ENSMUSP00000124725.2, ENSMUST00000161247.2
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs
  6. NM_001424467.1NP_001411396.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

    Status: VALIDATED

    Source sequence(s)
    AC130831
    UniProtKB/Swiss-Prot
    P63213, Q3TYE8
  7. NM_001424468.1NP_001411397.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

    Status: VALIDATED

    Source sequence(s)
    AC130831
    UniProtKB/Swiss-Prot
    P63213, Q3TYE8
  8. NM_010315.4NP_034445.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

    See identical proteins and their annotated locations for NP_034445.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-6 encode the same protein.
    Source sequence(s)
    AC130831, AK158697, AK160396, BY245532
    Consensus CDS
    CCDS26840.1
    UniProtKB/Swiss-Prot
    P63213, Q3TYE8
    Related
    ENSMUSP00000125697.2, ENSMUST00000160013.8
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    19922626..20027893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247652.1XP_030103512.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

    UniProtKB/Swiss-Prot
    P63213, Q3TYE8
    Conserved Domains (1) summary
    smart00224
    Location:971
    GGL; G protein gamma subunit-like motifs