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ERRFI1 ERBB receptor feedback inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 54206, updated on 19-Aug-2018

Summary

Official Symbol
ERRFI1provided by HGNC
Official Full Name
ERBB receptor feedback inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:18185
See related
Ensembl:ENSG00000116285 MIM:608069; Vega:OTTHUMG00000001221
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIG6; RALT; MIG-6; GENE-33
Summary
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in liver (RPKM 123.7), gall bladder (RPKM 60.1) and 20 other tissues See more
Orthologs

Genomic context

See ERRFI1 in Genome Data Viewer
Location:
1p36.23
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (8011719..8026333, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (8071779..8086393, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 9 Neighboring gene Parkinsonism associated deglycase Neighboring gene ribosomal protein L7a pseudogene 18 Neighboring gene VISTA enhancer hs1833

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of ERBB receptor feedback inhibitor 1 (ERRFI1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
    Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular hyperosmotic response IEA
Inferred from Electronic Annotation
more info
 
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
lung alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung epithelium development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
negative regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of epidermal growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epidermal growth factor-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of keratinocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
skin morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ERBB receptor feedback inhibitor 1
Names
mitogen-inducible gene 6 protein
receptor-associated late transducer

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018948.3NP_061821.1  ERBB receptor feedback inhibitor 1

    See identical proteins and their annotated locations for NP_061821.1

    Status: VALIDATED

    Source sequence(s)
    AK096149, AL137274, BC025337, DB033666
    Consensus CDS
    CCDS94.1
    UniProtKB/Swiss-Prot
    Q9UJM3
    UniProtKB/TrEMBL
    B3KTV8, I6S2Y9
    Related
    ENSP00000366702.5, OTTHUMP00000001359, ENST00000377482.9, OTTHUMT00000003617
    Conserved Domains (2) summary
    pfam09027
    Location:468
    GTPase_binding; GTPase binding
    pfam11555
    Location:315367
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    8011719..8026333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541596.3XP_011539898.1  ERBB receptor feedback inhibitor 1 isoform X3

    Conserved Domains (1) summary
    pfam11555
    Location:240292
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
  2. XM_005263477.3XP_005263534.1  ERBB receptor feedback inhibitor 1 isoform X2

    Conserved Domains (1) summary
    pfam11555
    Location:264316
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
  3. XM_006710697.3XP_006710760.1  ERBB receptor feedback inhibitor 1 isoform X1

    See identical proteins and their annotated locations for XP_006710760.1

    UniProtKB/Swiss-Prot
    Q9UJM3
    UniProtKB/TrEMBL
    I6S2Y9
    Conserved Domains (2) summary
    pfam09027
    Location:468
    GTPase_binding; GTPase binding
    pfam11555
    Location:315367
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
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