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ERRFI1 ERBB receptor feedback inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 54206, updated on 3-Mar-2026
Official Symbol
ERRFI1provided by HGNC
Official Full Name
ERBB receptor feedback inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:18185
See related
Ensembl:ENSG00000116285 MIM:608069; AllianceGenome:HGNC:18185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIG6; RALT; MIG-6; GENE-33
Summary
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in liver (RPKM 123.7), gall bladder (RPKM 60.1) and 20 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ERRFI1 in Genome Data Viewer
Location:
1p36.23
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (8011727..8026309, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (7542658..7557236, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (8071787..8086369, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:8020839-8021622 and GRCh37_chr1:8021623-8022406 Neighboring gene Parkinsonism associated deglycase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 98 Neighboring gene NANOG hESC enhancer GRCh37_chr1:8051898-8052428 Neighboring gene uncharacterized LOC124903834 Neighboring gene Sharpr-MPRA regulatory region 3725 Neighboring gene Sharpr-MPRA regulatory region 3772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 191 Neighboring gene ERRFI1 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 2737 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:8105847-8107046 Neighboring gene MPRA-validated peak44 silencer Neighboring gene ribosomal protein L7a pseudogene 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:8127937-8128436 Neighboring gene VISTA enhancer hs1833 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:8154529-8155728 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:8156741-8157940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:8175654-8176154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 100 Neighboring gene uncharacterized LOC107984915

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAF(V600E) positive papillary thyroid cancers. Ruan DT, et al. Surgery, 2008 Dec. PMID 19040996
  2. Low expression of Mig-6 is associated with poor survival outcome in NSCLC and inhibits cell apoptosis via ERK-mediated upregulation of Bcl-2. Li Z, et al. Oncol Rep, 2014 Apr. PMID 24573418
  3. Mig-6 participates in the regulation of cell senescence and retinoblastoma protein phosphorylation. Milewska M, et al. Cell Signal, 2014 Sep. PMID 24815188
  4. The mitogen-inducible gene-6 is involved in regulation of cellular senescence in normal diploid fibroblasts. Xie B, et al. Biol Cell, 2013 Oct. PMID 23746120
  5. Novel ERBB receptor feedback inhibitor 1 (ERRFI1) + 808 T/G polymorphism confers protective effect on diabetic nephropathy in a Korean population. Lee IS, et al. Dis Markers, 2013. PMID 23324575, Free PMC Article

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Potentially functional variants of ERRFI1 in hypoxia-related genes predict survival of non-small cell lung cancer patients.
    Title: Potentially functional variants of ERRFI1 in hypoxia-related genes predict survival of non-small cell lung cancer patients.
  2. MIG6 loss confers resistance to ALK/ROS1 inhibitors in NSCLC through EGFR activation by low-dose EGF.
    Title: MIG6 loss confers resistance to ALK/ROS1 inhibitors in NSCLC through EGFR activation by low-dose EGF.
  3. Effect of Gene 33/Mig6/ERRFI1 on hexavalent chromium-induced transformation of human bronchial epithelial cells depends on the length of exposure.
    Title: Effect of Gene 33/Mig6/ERRFI1 on hexavalent chromium-induced transformation of human bronchial epithelial cells depends on the length of exposure.
  4. MIG-6 Is Critical for Progesterone Responsiveness in Human Complex Atypical Hyperplasia and Early-Stage Endometrial Cancer.
    Title: MIG-6 Is Critical for Progesterone Responsiveness in Human Complex Atypical Hyperplasia and Early-Stage Endometrial Cancer.
  5. Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.
    Title: Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.
  6. Molecular insight into the affinity, specificity and cross-reactivity of systematic hepatocellular carcinoma RALT interaction profile with human receptor tyrosine kinases.
    Title: Molecular insight into the affinity, specificity and cross-reactivity of systematic hepatocellular carcinoma RALT interaction profile with human receptor tyrosine kinases.
  7. Mig6 not only inhibits EGFR and HER2 but also targets HER3 and HER4 in a differential specificity: Implications for targeted esophageal cancer therapy.
    Title: Mig6 not only inhibits EGFR and HER2 but also targets HER3 and HER4 in a differential specificity: Implications for targeted esophageal cancer therapy.
  8. Mig-6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma.
    Title: Mig-6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma.
  9. Suppression of Mig-6 overcomes the acquired EGFR-TKI resistance of lung adenocarcinoma.
    Title: Suppression of Mig-6 overcomes the acquired EGFR-TKI resistance of lung adenocarcinoma.
  10. Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas.
    Title: Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas.
Submit: New GeneRIF Correction See all GeneRIFs (75)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of ERBB receptor feedback inhibitor 1 (ERRFI1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
 PubMed 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular hyperosmotic response IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in lung alveolus development IEA
Inferred from Electronic Annotation
more info
  
involved_in lung alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lung epithelium development IEA
Inferred from Electronic Annotation
more info
  
involved_in lung epithelium development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lung vasculature development IEA
Inferred from Electronic Annotation
more info
  
involved_in lung vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epidermal growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of keratinocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in skin morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in skin morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
ERBB receptor feedback inhibitor 1
Names
mitogen-inducible gene 6 protein
receptor-associated late transducer

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018948.4 → NP_061821.1  ERBB receptor feedback inhibitor 1

    See identical proteins and their annotated locations for NP_061821.1

    Status: VALIDATED

    Source sequence(s)
    AK096149, AL137274, BC025337, DB033666
    Consensus CDS
    CCDS94.1
    UniProtKB/Swiss-Prot
    B2RDX9, Q9NTG9, Q9UD05, Q9UJM3
    UniProtKB/TrEMBL
    A0A024R4I1, B3KTV8, I6S2Y9
    Related
    ENSP00000366702.5, ENST00000377482.10
    Conserved Domains (2) summary
    pfam09027
    Location:4 → 68
    GTPase_binding; GTPase binding
    pfam11555
    Location:315 → 367
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    8011727..8026309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422698.1 → XP_047278654.1  ERBB receptor feedback inhibitor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RDX9, Q9NTG9, Q9UD05, Q9UJM3
    UniProtKB/TrEMBL
    A0A024R4I1, B3KTV8, I6S2Y9
    Related
    ENSP00000527183.1, ENST00000857124.1

  2. XM_005263477.4 → XP_005263534.1  ERBB receptor feedback inhibitor 1 isoform X2

    UniProtKB/TrEMBL
    B3KTV8
    Conserved Domains (1) summary
    pfam11555
    Location:264 → 316
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  3. XM_047422701.1 → XP_047278657.1  ERBB receptor feedback inhibitor 1 isoform X3

    UniProtKB/TrEMBL
    B3KTV8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    7542658..7557236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337101.1 → XP_054193076.1  ERBB receptor feedback inhibitor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RDX9, Q9NTG9, Q9UD05, Q9UJM3
    UniProtKB/TrEMBL
    A0A024R4I1, B3KTV8, I6S2Y9

  2. XM_054337102.1 → XP_054193077.1  ERBB receptor feedback inhibitor 1 isoform X2

    UniProtKB/TrEMBL
    B3KTV8

  3. XM_054337103.1 → XP_054193078.1  ERBB receptor feedback inhibitor 1 isoform X3

    UniProtKB/TrEMBL
    B3KTV8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UJM3.1 GenPept UniProtKB/Swiss-Prot:Q9UJM3

Gene LinkOut

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