Rragc Ras-related GTP binding C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rragcprovided by MGI
Official Full Name: Ras-related GTP binding Cprovided by MGI
Primary source: MGI:MGI:1858751
See related: Ensembl:ENSMUSG00000028646 AllianceGenome:MGI:1858751
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gtr2; RAGC; TIB929; YGR163W
Summary: Predicted to enable several functions, including GTPase binding activity; guanyl ribonucleotide binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Predicted to act upstream of or within several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of translational initiation; and vacuole organization. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of FNIP-folliculin RagC/D GAP and Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosomal membrane and nucleus. Orthologous to human RRAGC (Ras related GTP binding C). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in placenta adult (RPKM 33.1), subcutaneous fat pad adult (RPKM 30.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 57.42 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (123811226..123830790)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (123917433..123936997)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
Title: TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
The constitutively active RagA-RagC heterodimer blocks the inhibitory effect of alcohol (EtOH).
Title: Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTPase binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables enzyme-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables enzyme-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables membrane-membrane adaptor activity	IEA Inferred from Electronic Annotation more info
enables membrane-membrane adaptor activity	ISO Inferred from Sequence Orthology more info
enables membrane-membrane adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytoplasmic translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of translational initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to lysosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to lysosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to lysosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid	IEA Inferred from Electronic Annotation more info
involved_in response to amino acid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FNIP-folliculin RagC/D GAP	IEA Inferred from Electronic Annotation more info
part_of FNIP-folliculin RagC/D GAP	ISO Inferred from Sequence Orthology more info
part_of Gtr1-Gtr2 GTPase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ras-related GTP-binding protein C

Names: GTPase-interacting protein 2; rag C; small GTPase, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.