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RRAGC Ras related GTP binding C [ Homo sapiens (human) ]

Gene ID: 64121, updated on 9-May-2020

Summary

Official Symbol
RRAGCprovided by HGNC
Official Full Name
Ras related GTP binding Cprovided by HGNC
Primary source
HGNC:HGNC:19902
See related
Ensembl:ENSG00000116954 MIM:608267
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTR2; RAGC; TIB929
Summary
This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in fat (RPKM 23.8), placenta (RPKM 15.8) and 25 other tissues See more
Orthologs

Genomic context

See RRAGC in Genome Data Viewer
Location:
1p34.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (38838198..38859772, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (39303869..39325495, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378660 Neighboring gene VISTA enhancer hs1031 Neighboring gene VISTA enhancer hs1139 Neighboring gene Sharpr-MPRA regulatory region 3933 Neighboring gene GJA9-MYCBP readthrough Neighboring gene uncharacterized LOC105378663 Neighboring gene MYC binding protein Neighboring gene gap junction protein alpha 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MYCBP

Homology

Clone Names

  • FLJ13311

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GDP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
magnesium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
cell cycle arrest TAS
Traceable Author Statement
more info
 
cellular protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to amino acid starvation IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of TOR signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of macroautophagy TAS
Traceable Author Statement
more info
 
response to amino acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
EGO complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras-related GTP-binding protein C
Names
GTPase-interacting protein 2
Rag C protein
NP_001258780.1
NP_071440.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271851.2NP_001258780.1  ras-related GTP-binding protein C isoform 2

    See identical proteins and their annotated locations for NP_001258780.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AK298573, AK298788, AW327252, BC016668, BI461665, BQ003663, CB132041, CX761032, ES308561, HY202961, HY264464
    UniProtKB/Swiss-Prot
    Q9HB90
    UniProtKB/TrEMBL
    B4DQ03, B4DQG4
    Conserved Domains (1) summary
    cd11385
    Location:63203
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
  2. NM_022157.4NP_071440.1  ras-related GTP-binding protein C isoform 1

    See identical proteins and their annotated locations for NP_071440.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK315791, BC016668, BI461665, BQ003663, CA449149, CB132041, CX761032, HY202961, HY264464
    Consensus CDS
    CCDS430.1
    UniProtKB/Swiss-Prot
    Q9HB90
    Related
    ENSP00000362092.3, ENST00000373001.4
    Conserved Domains (1) summary
    cd11385
    Location:63237
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    38838198..38859772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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