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RIPK4 receptor interacting serine/threonine kinase 4 [ Homo sapiens (human) ]

Gene ID: 54101, updated on 20-Dec-2019

Summary

Official Symbol
RIPK4provided by HGNC
Official Full Name
receptor interacting serine/threonine kinase 4provided by HGNC
Primary source
HGNC:HGNC:496
See related
Ensembl:ENSG00000183421 MIM:605706
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIK; PKK; PPS2; RIP4; ANKK2; NKRD3; ANKRD3; CHANDS
Summary
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in esophagus (RPKM 16.7), kidney (RPKM 9.9) and 16 other tissues See more
Orthologs

Genomic context

See RIPK4 in Genome Data Viewer
Location:
21q22.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (41739373..41767052, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43159529..43187249, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 479 Neighboring gene long intergenic non-protein coding RNA 112 Neighboring gene microRNA 6814 Neighboring gene uncharacterized LOC102724800 Neighboring gene Sharpr-MPRA regulatory region 172 Neighboring gene PR/SET domain 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129992, MGC129993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
receptor-interacting serine/threonine-protein kinase 4
Names
PKC-delta-interacting protein kinase
ankyrin repeat domain-containing protein 3
protein kinase C-associated kinase
serine/threonine-protein kinase ANKRD3
NP_065690.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032113.2 RefSeqGene

    Range
    5038..32717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020639.3NP_065690.2  receptor-interacting serine/threonine-protein kinase 4

    See identical proteins and their annotated locations for NP_065690.2

    Status: REVIEWED

    Source sequence(s)
    AJ278016, AK027424, BC035755, BM979316
    Consensus CDS
    CCDS13675.1
    UniProtKB/TrEMBL
    Q96T11, Q9H4D1
    Related
    ENSP00000332454.3, ENST00000332512.8
    Conserved Domains (5) summary
    smart00221
    Location:26279
    STYKc; Protein kinase; unclassified specificity
    cd00204
    Location:598723
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14025
    Location:25290
    STKc_RIP4_like; Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins
    pfam12796
    Location:608699
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:603634
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    41739373..41767052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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