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Ripk4 receptor-interacting serine-threonine kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 72388, updated on 26-Sep-2022

Summary

Official Symbol
Ripk4provided by MGI
Official Full Name
receptor-interacting serine-threonine kinase 4provided by MGI
Primary source
MGI:MGI:1919638
See related
Ensembl:ENSMUSG00000005251 AllianceGenome:MGI:1919638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DIk; PKK; RIP4; ANKK2; Ankrd3; 2310069J12Rik
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in morphogenesis of an epithelium and positive regulation of NF-kappaB transcription factor activity. Predicted to act upstream of or within phosphorylation. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study popliteal pterygium syndrome. Orthologous to human RIPK4 (receptor interacting serine/threonine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 16.9), colon adult (RPKM 10.1) and 17 other tissues See more
Orthologs
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Genomic context

See Ripk4 in Genome Data Viewer
Location:
16; 16 C4
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (97543133..97564979, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (97741933..97763779, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41512 Neighboring gene predicted gene, 41513 Neighboring gene PR domain containing 15 Neighboring gene C2 calcium-dependent domain containing 2 Neighboring gene microRNA 6964

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in morphogenesis of an epithelium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
receptor-interacting serine/threonine-protein kinase 4
Names
PKC-associated protein kinase
PKC-regulated protein kinase
ankyrin repeat domain-containing protein 3
NP_076152.2
XP_011244456.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023663.7NP_076152.2  receptor-interacting serine/threonine-protein kinase 4

    See identical proteins and their annotated locations for NP_076152.2

    Status: VALIDATED

    Source sequence(s)
    AC121560
    Consensus CDS
    CCDS28360.1
    UniProtKB/Swiss-Prot
    Q3UM04, Q9ERK0
    Related
    ENSMUSP00000019386.9, ENSMUST00000019386.10
    Conserved Domains (5) summary
    smart00219
    Location:26279
    TyrKc; Tyrosine kinase, catalytic domain
    cd00204
    Location:600725
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14025
    Location:25290
    STKc_RIP4_like; Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins
    pfam12796
    Location:610701
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:605636
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    97543133..97564979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246154.2XP_011244456.1  receptor-interacting serine/threonine-protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    D3YXY4
    Conserved Domains (4) summary
    PHA03095
    Location:410654
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:542573
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:613703
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:1227
    PKc_like; Protein Kinases, catalytic domain