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ACP5 acid phosphatase 5, tartrate resistant [ Homo sapiens (human) ]

Gene ID: 54, updated on 7-Dec-2018

Summary

Official Symbol
ACP5provided by HGNC
Official Full Name
acid phosphatase 5, tartrate resistantprovided by HGNC
Primary source
HGNC:HGNC:124
See related
Ensembl:ENSG00000102575 MIM:171640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPAP; TRAP; TRACP5a; TRACP5b; TrATPase
Summary
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
Expression
Broad expression in lung (RPKM 55.0), kidney (RPKM 29.2) and 16 other tissues See more
Orthologs

Genomic context

See ACP5 in Genome Data Viewer
Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (11574660..11579008, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11685475..11689801, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene calponin 1 Neighboring gene elongation factor 1 homolog Neighboring gene zinc finger protein 627 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 76 Neighboring gene vomeronasal 2 receptor 12 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Spondyloenchondrodysplasia with immune dysregulation
MedGen: C1842763 OMIM: 607944 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of acid phosphatase 5, tartrate resistant (ACP5) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
  • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
  • Osteoclast Signaling, organism-specific biosystem (from WikiPathways)
    Osteoclast Signaling, organism-specific biosystem
    Osteoclast Signaling
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway, organism-specific biosystemRANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG (Osteoprotegerin) are three important mol...
  • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
    Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Rheumatoid arthritis, conserved biosystem (from KEGG)
    Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Riboflavin metabolism, organism-specific biosystem (from KEGG)
    Riboflavin metabolism, organism-specific biosystem
    Riboflavin metabolism
  • Riboflavin metabolism, conserved biosystem (from KEGG)
    Riboflavin metabolism, conserved biosystem
    Riboflavin metabolism
  • Vitamin B2 (riboflavin) metabolism, organism-specific biosystem (from REACTOME)
    Vitamin B2 (riboflavin) metabolism, organism-specific biosystemRiboflavin (vitamin B2, E101) is an essential component for the cofactors FAD (flavin-adenine dinucleotide) and FMN (flavin mononucleotide). Together with NAD+ and NADP+, FAD and FMN are important hy...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117378

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acid phosphatase activity TAS
Traceable Author Statement
more info
 
ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ferric iron binding IDA
Inferred from Direct Assay
more info
PubMed 
ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ferrous iron binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bone morphogenesis IEA
Inferred from Electronic Annotation
more info
 
bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
ossification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to cytokine IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
riboflavin metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tartrate-resistant acid phosphatase type 5
Names
human purple acid phosphatase
tartrate-resistant acid ATPase
tartrate-resistant acid phosphatase 5a
tartrate-resistant acid phosphatase 5b
NP_001104504.1
NP_001104505.1
NP_001104506.1
NP_001308952.1
NP_001602.1
XP_005259995.1
XP_011526371.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028127.1 RefSeqGene

    Range
    6342..9327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1218

mRNA and Protein(s)

  1. NM_001111034.2NP_001104504.1  tartrate-resistant acid phosphatase type 5 precursor

    See identical proteins and their annotated locations for NP_001104504.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    BC025414, BP367008
    Consensus CDS
    CCDS12265.1
    UniProtKB/Swiss-Prot
    P13686
    UniProtKB/TrEMBL
    A0A024R7F8
    Conserved Domains (1) summary
    cd07378
    Location:26311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
  2. NM_001111035.2NP_001104505.1  tartrate-resistant acid phosphatase type 5 precursor

    See identical proteins and their annotated locations for NP_001104505.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 encode the same protein.
    Source sequence(s)
    BC025414, BC111014, BP334409
    Consensus CDS
    CCDS12265.1
    UniProtKB/Swiss-Prot
    P13686
    UniProtKB/TrEMBL
    A0A024R7F8
    Related
    ENSP00000218758.4, ENST00000218758.9
    Conserved Domains (1) summary
    cd07378
    Location:26311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
  3. NM_001111036.2NP_001104506.1  tartrate-resistant acid phosphatase type 5 precursor

    See identical proteins and their annotated locations for NP_001104506.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    BC025414, BP334409, BX365007
    Consensus CDS
    CCDS12265.1
    UniProtKB/Swiss-Prot
    P13686
    UniProtKB/TrEMBL
    A0A024R7F8
    Related
    ENSP00000392374.1, ENST00000412435.6
    Conserved Domains (1) summary
    cd07378
    Location:26311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
  4. NM_001322023.1NP_001308952.1  tartrate-resistant acid phosphatase type 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC020947, BC025414, BP334409
    Consensus CDS
    CCDS12265.1
    UniProtKB/Swiss-Prot
    P13686
    UniProtKB/TrEMBL
    A0A024R7F8
    Conserved Domains (1) summary
    cd07378
    Location:26311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
  5. NM_001611.5NP_001602.1  tartrate-resistant acid phosphatase type 5 precursor

    See identical proteins and their annotated locations for NP_001602.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AK290717, BC025414
    Consensus CDS
    CCDS12265.1
    UniProtKB/Swiss-Prot
    P13686
    UniProtKB/TrEMBL
    A0A024R7F8
    Related
    ENSP00000413456.1, ENST00000433365.2
    Conserved Domains (1) summary
    cd07378
    Location:26311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    11574660..11579008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528069.2XP_011526371.1  tartrate-resistant acid phosphatase type 5 isoform X1

    See identical proteins and their annotated locations for XP_011526371.1

    UniProtKB/Swiss-Prot
    P13686
    UniProtKB/TrEMBL
    A0A024R7F8
    Conserved Domains (1) summary
    cd07378
    Location:26311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
  2. XM_005259938.1XP_005259995.1  tartrate-resistant acid phosphatase type 5 isoform X1

    See identical proteins and their annotated locations for XP_005259995.1

    UniProtKB/Swiss-Prot
    P13686
    UniProtKB/TrEMBL
    A0A024R7F8
    Related
    ENSP00000468767.1, ENST00000592828.5
    Conserved Domains (1) summary
    cd07378
    Location:26311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
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