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Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit [ Mus musculus (house mouse) ]

Gene ID: 53895, updated on 8-Feb-2024

Summary

Official Symbol
Clppprovided by MGI
Official Full Name
caseinolytic mitochondrial matrix peptidase proteolytic subunitprovided by MGI
Primary source
MGI:MGI:1858213
See related
Ensembl:ENSMUSG00000002660 AllianceGenome:MGI:1858213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D17Wsu160e
Summary
Predicted to enable ATP-dependent peptidase activity; ATPase binding activity; and serine-type endopeptidase activity. Predicted to be involved in membrane protein proteolysis and protein quality control for misfolded or incompletely synthesized proteins. Located in mitochondrion. Is expressed in several structures, including extraembryonic component; liver; lung; pancreas; and placenta. Used to study Perrault syndrome. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 124.9), ovary adult (RPKM 93.5) and 28 other tissues See more
Orthologs
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Genomic context

See Clpp in Genome Data Viewer
Location:
17 D; 17 29.61 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57297264..57303371)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56990264..56996371)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene alkaline ceramidase 1 Neighboring gene predicted gene, 33509 Neighboring gene STARR-positive B cell enhancer ABC_E491 Neighboring gene alkB homolog 7 Neighboring gene persephin Neighboring gene general transcription factor IIF, polypeptide 1 Neighboring gene STARR-positive B cell enhancer ABC_E492

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP-dependent peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of endopeptidase Clp complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of endopeptidase Clp complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Names
ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit
caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog
caseinolytic protease, ATP-dependent, proteolytic subunit homolog
endopeptidase Clp
putative ATP-dependent Clp protease proteolytic subunit, mitochondrial
NP_059089.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017393.2NP_059089.1  ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor

    See identical proteins and their annotated locations for NP_059089.1

    Status: VALIDATED

    Source sequence(s)
    AC073683, AK145765, BY294002
    Consensus CDS
    CCDS28920.1
    UniProtKB/Swiss-Prot
    O88696, Q3TI13
    UniProtKB/TrEMBL
    Q3UGW4
    Related
    ENSMUSP00000002735.8, ENSMUST00000002735.9
    Conserved Domains (1) summary
    PRK00277
    Location:53245
    clpP; ATP-dependent Clp protease proteolytic subunit; Reviewed

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57297264..57303371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)