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CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit [ Homo sapiens (human) ]

Gene ID: 8192, updated on 19-Sep-2024

Summary

Official Symbol
CLPPprovided by HGNC
Official Full Name
caseinolytic mitochondrial matrix peptidase proteolytic subunitprovided by HGNC
Primary source
HGNC:HGNC:2084
See related
Ensembl:ENSG00000125656 MIM:601119; AllianceGenome:HGNC:2084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DFNB81; PRLTS3
Summary
The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 19.9), fat (RPKM 18.0) and 25 other tissues See more
Orthologs
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Genomic context

See CLPP in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6361531..6370242)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6350432..6359144)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6361542..6370253)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6216753-6217667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6227079-6227744 Neighboring gene MLLT1 super elongation complex subunit Neighboring gene Sharpr-MPRA regulatory region 3427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6239861-6240362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6243510-6244224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6263043-6263544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6263545-6264044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6273107-6273706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6276605-6277105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9947 Neighboring gene alkaline ceramidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6362217-6363174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6372537-6373459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6387043-6387543 Neighboring gene alkB homolog 7 Neighboring gene general transcription factor IIF subunit 1 Neighboring gene persephin Neighboring gene microRNA 6885

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP-dependent peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP-dependent peptidase activity TAS
Traceable Author Statement
more info
 
enables ATPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of endopeptidase Clp complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of endopeptidase Clp complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of endopeptidase Clp complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Names
ATP-dependent protease ClpAP, proteolytic subunit, human
ClpP caseinolytic peptidase ATP-dependent, proteolytic subunit
ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog
ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog
endopeptidase Clp
putative ATP-dependent Clp protease proteolytic subunit, mitochondrial
NP_006003.1
XP_047295442.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033887.1 RefSeqGene

    Range
    5080..13791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1402

mRNA and Protein(s)

  1. NM_006012.4NP_006003.1  ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor

    Status: REVIEWED

    Source sequence(s)
    AC011491, BC002956
    Consensus CDS
    CCDS12162.1
    UniProtKB/Swiss-Prot
    B2R4W5, Q16740
    Related
    ENSP00000245816.3, ENST00000245816.11
    Conserved Domains (1) summary
    PRK00277
    Location:55249
    clpP; ATP-dependent Clp protease proteolytic subunit; Reviewed

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    6361531..6370242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439486.1XP_047295442.1  ATP-dependent Clp protease proteolytic subunit, mitochondrial isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    6350432..6359144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)