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CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit [ Homo sapiens (human) ]

Gene ID: 8192, updated on 12-Jan-2019

Summary

Official Symbol
CLPPprovided by HGNC
Official Full Name
caseinolytic mitochondrial matrix peptidase proteolytic subunitprovided by HGNC
Primary source
HGNC:HGNC:2084
See related
Ensembl:ENSG00000125656 MIM:601119
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DFNB81; PRLTS3
Summary
The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 19.9), fat (RPKM 18.0) and 25 other tissues See more
Orthologs

Genomic context

See CLPP in Genome Data Viewer
Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (6361452..6368904)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6361463..6368915)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MLLT1, super elongation complex subunit Neighboring gene alkaline ceramidase 1 Neighboring gene alkB homolog 7 Neighboring gene general transcription factor IIF subunit 1 Neighboring gene persephin Neighboring gene microRNA 6885

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP-dependent peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
protein quality control for misfolded or incompletely synthesized proteins IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis involved in cellular protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endopeptidase Clp complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase Clp complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Names
ATP-dependent protease ClpAP, proteolytic subunit, human
ClpP caseinolytic peptidase ATP-dependent, proteolytic subunit
ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog
ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog
endopeptidase Clp
putative ATP-dependent Clp protease proteolytic subunit, mitochondrial
NP_006003.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033887.1 RefSeqGene

    Range
    5001..12453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006012.3NP_006003.1  ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor

    See identical proteins and their annotated locations for NP_006003.1

    Status: REVIEWED

    Source sequence(s)
    BC002956, BF339807
    Consensus CDS
    CCDS12162.1
    UniProtKB/Swiss-Prot
    Q16740
    Related
    ENSP00000245816.3, ENST00000245816.9
    Conserved Domains (1) summary
    PRK00277
    Location:55249
    clpP; ATP-dependent Clp protease proteolytic subunit; Reviewed

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    6361452..6368904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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