U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nudt5 nudix hydrolase 5 [ Mus musculus (house mouse) ]

Gene ID: 53893, updated on 6-Jun-2024

Summary

Official Symbol
Nudt5provided by MGI
Official Full Name
nudix hydrolase 5provided by MGI
Primary source
MGI:MGI:1858232
See related
Ensembl:ENSMUSG00000025817 AllianceGenome:MGI:1858232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables nucleoside-diphosphatase activity and snoRNA binding activity. Acts upstream of or within nucleobase-containing compound metabolic process. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and respiratory system. Orthologous to human NUDT5 (nudix hydrolase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.2), liver E14 (RPKM 9.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nudt5 in Genome Data Viewer
Location:
2 A1; 2 3.62 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (5849839..5875631)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (5845034..5870820)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:5661717-5662018 Neighboring gene predicted gene, 29857 Neighboring gene STARR-seq mESC enhancer starr_03574 Neighboring gene STARR-seq mESC enhancer starr_03576 Neighboring gene cell division cycle 123 Neighboring gene predicted gene, 29984 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:5766095-5766344 Neighboring gene STARR-seq mESC enhancer starr_03579 Neighboring gene predicted gene 13199 Neighboring gene SEC61 translocon subunit alpha 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:5816293-5816594 Neighboring gene predicted gene 13267 Neighboring gene dehydrogenase E1 and transketolase domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 8-oxo-GDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables 8-oxo-dGDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables ADP-ribose diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ADP-ribose diphosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables ADP-sugar diphosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleoside diphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotidyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables snoRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ATP generation from poly-ADP-D-ribose ISO
Inferred from Sequence Orthology
more info
 
involved_in D-ribose catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nucleobase-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleoside phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ribonucleoside diphosphate catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ribose phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ADP-sugar pyrophosphatase
Names
8-oxo-dGDP phosphatase
nuclear ATP-synthesis protein NUDIX5
nucleoside diphosphate-linked moiety X motif 5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
nudix motif 5
NP_001405336.1
NP_001405337.1
NP_001405338.1
NP_001405339.1
NP_001405340.1
NP_001405341.1
NP_001405342.1
NP_001405343.1
NP_001405344.1
NP_001405345.1
NP_001405346.1
NP_058614.1
XP_006497574.1
XP_036018286.1
XP_036018287.1
XP_036018288.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418407.1NP_001405336.1  ADP-sugar pyrophosphatase isoform b

    Status: VALIDATED

    Source sequence(s)
    AL928924
  2. NM_001418408.1NP_001405337.1  ADP-sugar pyrophosphatase isoform b

    Status: VALIDATED

    Source sequence(s)
    AL928924
  3. NM_001418409.1NP_001405338.1  ADP-sugar pyrophosphatase isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928924
    UniProtKB/TrEMBL
    A2ATT5
  4. NM_001418410.1NP_001405339.1  ADP-sugar pyrophosphatase isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928924
    UniProtKB/TrEMBL
    A2ATT5
  5. NM_001418411.1NP_001405340.1  ADP-sugar pyrophosphatase isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928924
    UniProtKB/TrEMBL
    A2ATT5
  6. NM_001418412.1NP_001405341.1  ADP-sugar pyrophosphatase isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928924
    UniProtKB/TrEMBL
    A2ATT5
  7. NM_001418413.1NP_001405342.1  ADP-sugar pyrophosphatase isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928924
    UniProtKB/TrEMBL
    A2ATT5
    Related
    ENSMUSP00000117670.2, ENSMUST00000127116.7
  8. NM_001418414.1NP_001405343.1  ADP-sugar pyrophosphatase isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928924
    UniProtKB/TrEMBL
    A2ATT5
  9. NM_001418415.1NP_001405344.1  ADP-sugar pyrophosphatase isoform d

    Status: VALIDATED

    Source sequence(s)
    AL928924
  10. NM_001418416.1NP_001405345.1  ADP-sugar pyrophosphatase isoform d

    Status: VALIDATED

    Source sequence(s)
    AL928924
  11. NM_001418417.1NP_001405346.1  ADP-sugar pyrophosphatase isoform d

    Status: VALIDATED

    Source sequence(s)
    AL928924
  12. NM_016918.4NP_058614.1  ADP-sugar pyrophosphatase isoform a

    See identical proteins and their annotated locations for NP_058614.1

    Status: VALIDATED

    Source sequence(s)
    AL928924
    Consensus CDS
    CCDS15667.1
    UniProtKB/Swiss-Prot
    A2ATT6, Q99KM4, Q9JKX6
    Related
    ENSMUSP00000026927.4, ENSMUST00000026927.10
    Conserved Domains (1) summary
    cd03424
    Location:59206
    ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    5849839..5875631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162394.1XP_036018287.1  ADP-sugar pyrophosphatase isoform X3

    UniProtKB/Swiss-Prot
    A2ATT6, Q99KM4, Q9JKX6
    Conserved Domains (1) summary
    cd03424
    Location:59206
    ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...
  2. XM_036162395.1XP_036018288.1  ADP-sugar pyrophosphatase isoform X3

    UniProtKB/Swiss-Prot
    A2ATT6, Q99KM4, Q9JKX6
    Conserved Domains (1) summary
    cd03424
    Location:59206
    ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...
  3. XM_006497511.4XP_006497574.1  ADP-sugar pyrophosphatase isoform X2

    Conserved Domains (1) summary
    cd03424
    Location:105249
    ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...
  4. XM_036162393.1XP_036018286.1  ADP-sugar pyrophosphatase isoform X1

    Conserved Domains (1) summary
    cd03424
    Location:105252
    ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...