Format

Send to:

Choose Destination

NUDT5 nudix hydrolase 5 [ Homo sapiens (human) ]

Gene ID: 11164, updated on 18-Aug-2020

Summary

Official Symbol
NUDT5provided by HGNC
Official Full Name
nudix hydrolase 5provided by HGNC
Primary source
HGNC:HGNC:8052
See related
Ensembl:ENSG00000165609 MIM:609230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YSA1; YSA1H; YSAH1; hNUDT5
Summary
This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in liver (RPKM 12.0), skin (RPKM 11.4) and 25 other tissues See more
Orthologs

Genomic context

See NUDT5 in Genome Data Viewer
Location:
10p14
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (12165330..12195891, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (12209573..12238143, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene dehydrogenase E1 and transketolase domain containing 1 Neighboring gene RNA, U6 small nuclear 88, pseudogene Neighboring gene microRNA 548ak Neighboring gene SEC61 translocon subunit alpha 2 Neighboring gene cell division cycle 123 Neighboring gene FOXA motif-containing MPRA enhancer 241 Neighboring gene RNA, 7SL, cytoplasmic 198, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
8-oxo-dGDP phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
ADP-ribose diphosphatase activity EXP
Inferred from Experiment
more info
PubMed 
ADP-ribose diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ADP-ribose diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
ADP-sugar diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT m7G(5')pppN diphosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleotidyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
snoRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
ATP generation from poly-ADP-D-ribose IDA
Inferred from Direct Assay
more info
PubMed 
D-ribose catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
D-ribose catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
nucleobase-containing small molecule catabolic process TAS
Traceable Author Statement
more info
 
nucleoside phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
ribonucleoside diphosphate catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ribose phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADP-sugar pyrophosphatase
Names
8-oxo-dGDP phosphatase
nuclear ATP-synthesis protein NUDIX5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
NP_001308576.1
NP_001308577.1
NP_054861.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321647.2NP_001308576.1  ADP-sugar pyrophosphatase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073160, AL512770
    Conserved Domains (1) summary
    cd03424
    Location:60204
    ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...
  2. NM_001321648.2NP_001308577.1  ADP-sugar pyrophosphatase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC073160, AL512770
    Conserved Domains (1) summary
    cd03424
    Location:1121
    ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...
  3. NM_014142.4NP_054861.2  ADP-sugar pyrophosphatase isoform 1

    See identical proteins and their annotated locations for NP_054861.2

    Status: VALIDATED

    Source sequence(s)
    AC073160, AF155832, BC000025, CA944803
    Consensus CDS
    CCDS7089.1
    UniProtKB/Swiss-Prot
    Q9UKK9
    Related
    ENSP00000419628.1, ENST00000491614.6
    Conserved Domains (1) summary
    cd03424
    Location:60207
    ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    12165330..12195891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center