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TBXA2R thromboxane A2 receptor [ Bos taurus (domestic cattle) ]

Gene ID: 538783, updated on 17-Aug-2024

Summary

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Official Symbol
TBXA2Rprovided by VGNC
Official Full Name
thromboxane A2 receptorprovided by VGNC
Primary source
VGNC:VGNC:35673
See related
BGD:BT16577; Ensembl:ENSBTAG00000014944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (20330001..20343533)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Neighboring gene cactin, spliceosome C complex subunit Neighboring gene uncharacterized LOC100849681 Neighboring gene GIPC PDZ domain containing family member 3 Neighboring gene high mobility group 20B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, tissue-specific expression and regulation of the bovine thromboxane A2 receptor. Muck S, et al. Adv Exp Med Biol, 1997. PMID 9561101
  2. The bovine thromboxane A2 receptor: molecular cloning, expression, and functional characterization. Muck S, et al. Naunyn Schmiedebergs Arch Pharmacol, 1998 Jan. PMID 9459567
  3. Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase. Zhang M, et al. Arterioscler Thromb Vasc Biol, 2011 Jan. PMID 20947827, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables thromboxane A2 receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
thromboxane A2 receptor
Names
TXA2-R
prostanoid TP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167919.1 → NP_001161391.1  thromboxane A2 receptor

    See identical proteins and their annotated locations for NP_001161391.1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000007
    UniProtKB/Swiss-Prot
    Q95124, Q95125
    Conserved Domains (1) summary
    pfam00001
    Location:65 → 308
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    20330001..20343533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024994470.2 → XP_024850238.1  thromboxane A2 receptor isoform X1

    UniProtKB/TrEMBL
    A0AAA9S8X2
    Related
    ENSBTAP00000081734.1, ENSBTAT00000096872.1
    Conserved Domains (3) summary
    cd15143
    Location:27 → 51
    7tmA_TXA2_R; TM helix 1 [structural motif]
    cl26464
    Location:265 → 354
    Atrophin-1; Atrophin-1 family
    cl28897
    Location:25 → 262
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_005208963.5 → XP_005209020.1  thromboxane A2 receptor isoform X2

    See identical proteins and their annotated locations for XP_005209020.1

    UniProtKB/Swiss-Prot
    Q95124, Q95125
    Related
    ENSBTAP00000019892.3, ENSBTAT00000019892.5
    Conserved Domains (1) summary
    pfam00001
    Location:65 → 308
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. XM_059888325.1 → XP_059744308.1  thromboxane A2 receptor isoform X3

  4. XM_059888326.1 → XP_059744309.1  thromboxane A2 receptor isoform X4

  5. XM_059888324.1 → XP_059744307.1  thromboxane A2 receptor isoform X1

    UniProtKB/TrEMBL
    A0AAA9S8X2

RNA

  1. XR_003035388.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95125.2 GenPept UniProtKB/Swiss-Prot:Q95125

Gene LinkOut

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