Format

Send to:

Choose Destination

TBXA2R thromboxane A2 receptor [ Homo sapiens (human) ]

Gene ID: 6915, updated on 2-Aug-2020

Summary

Official Symbol
TBXA2Rprovided by HGNC
Official Full Name
thromboxane A2 receptorprovided by HGNC
Primary source
HGNC:HGNC:11608
See related
Ensembl:ENSG00000006638 MIM:188070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TXA2-R; BDPLT13
Summary
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Expression
Broad expression in fat (RPKM 1.2), spleen (RPKM 1.2) and 20 other tissues See more
Orthologs

Genomic context

See TBXA2R in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (3594507..3608749, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3594504..3606831, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene high mobility group 20B Neighboring gene GIPC PDZ domain containing family member 3 Neighboring gene CACTIN antisense RNA 1 Neighboring gene cactin, spliceosome C complex subunit Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Neighboring gene Sharpr-MPRA regulatory region 323

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 clade B gp120 induces higher levels of expression of the neuropathogenic molecule cyclooxygenase-2 (COX-2)-mediated arachidonic acid by-products, prostaglandin E2 (PGE2) and thromboxane A2 receptor (TBXA2R) compared to clade C gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thromboxane A2 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasoconstriction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
thromboxane A2 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
thromboxane A2 receptor
Names
prostanoid TP receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013363.1 RefSeqGene

    Range
    5001..17328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_578

mRNA and Protein(s)

  1. NM_001060.6NP_001051.1  thromboxane A2 receptor isoform alpha

    See identical proteins and their annotated locations for NP_001051.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longer transcript but encodes the shorter isoform (alpha).
    Source sequence(s)
    AC005175, AY429110, BC028027, BC121148, BM990145
    Consensus CDS
    CCDS42467.1
    UniProtKB/Swiss-Prot
    P21731
    UniProtKB/TrEMBL
    Q05C92, Q0VAB0
    Related
    ENSP00000364336.3, ENST00000375190.9
    Conserved Domains (1) summary
    pfam00001
    Location:42308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_201636.3NP_963998.2  thromboxane A2 receptor isoform beta

    See identical proteins and their annotated locations for NP_963998.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) uses an alternate splice pattern in the 3' coding region, compared to variant a. The resulting isoform (beta) has a longer and distinct C-terminus, compared to isoform alpha. This isoform is described in PMID: 8613548.
    Source sequence(s)
    AC005175, AY429110, BC028027, BC121148, BM990145, U11271
    Consensus CDS
    CCDS54198.1
    UniProtKB/Swiss-Prot
    P21731
    UniProtKB/TrEMBL
    Q05C92, Q0VAB0
    Related
    ENSP00000393333.2, ENST00000411851.3
    Conserved Domains (1) summary
    pfam00001
    Location:42308
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    3594507..3608749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528214.2XP_011526516.1  thromboxane A2 receptor isoform X1

    See identical proteins and their annotated locations for XP_011526516.1

    UniProtKB/Swiss-Prot
    P21731
    Conserved Domains (1) summary
    pfam00001
    Location:42308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
Support Center