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Rab11a RAB11A, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 53869, updated on 18-Apr-2024

Summary

Official Symbol
Rab11aprovided by MGI
Official Full Name
RAB11A, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1858202
See related
Ensembl:ENSMUSG00000004771 AllianceGenome:MGI:1858202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTP binding activity; GTPase activity; and cytoskeletal protein binding activity. Involved in melanosome transport. Acts upstream of or within positive regulation of axon extension and protein localization to cell surface. Located in several cellular components, including axon; perinuclear region of cytoplasm; and recycling endosome. Is expressed in several structures, including adrenal gland; early conceptus; esophagus; eye; and genitourinary system. Orthologous to human RAB11A (RAB11A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 50.9), bladder adult (RPKM 49.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
9 34.87 cM; 9 C
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64622582..64645038, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64715300..64737756, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DIS3 like exosome 3'-5' exoribonuclease Neighboring gene STARR-seq mESC enhancer starr_24432 Neighboring gene STARR-seq mESC enhancer starr_24433 Neighboring gene multiple EGF-like-domains 11 Neighboring gene STARR-seq mESC enhancer starr_24435 Neighboring gene STARR-positive B cell enhancer mm9_chr9:64519558-64519858 Neighboring gene STARR-positive B cell enhancer ABC_E9767 Neighboring gene predicted gene, 36311 Neighboring gene STARR-positive B cell enhancer ABC_E2294 Neighboring gene nuclear encoded tRNA glutamine 9 (anticodon CTG) Neighboring gene STARR-positive B cell enhancer mm9_chr9:64616787-64617087 Neighboring gene predicted gene, 36365

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables dynein light intermediate chain binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables myosin V binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta clearance by transcytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in astral microtubule organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in early endosome to recycling endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization to organelle ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of vesicle localization ISO
Inferred from Sequence Orthology
more info
 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in exosomal secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in melanosome transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in melanosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in multivesicular body assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cytokinetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to cilium ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of early endosome to recycling endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of multivesicular body size ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport in synapse ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in multivesicular body ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic recycling endosome ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Rab-11A
Names
rab-11
NP_059078.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017382.5NP_059078.2  ras-related protein Rab-11A

    See identical proteins and their annotated locations for NP_059078.2

    Status: VALIDATED

    Source sequence(s)
    AC147560, AK031143, AK147122
    Consensus CDS
    CCDS23282.1
    UniProtKB/Swiss-Prot
    P62492, Q3V1Z6
    UniProtKB/TrEMBL
    Q0PD45
    Related
    ENSMUSP00000129163.2, ENSMUST00000172298.8
    Conserved Domains (1) summary
    cd01868
    Location:9173
    Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64622582..64645038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)