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Zranb2 zinc finger, RAN-binding domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 53861, updated on 2-Nov-2024

Summary

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Official Symbol
Zranb2provided by MGI
Official Full Name
zinc finger, RAN-binding domain containing 2provided by MGI
Primary source
MGI:MGI:1858211
See related
Ensembl:ENSMUSG00000028180 AllianceGenome:MGI:1858211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zis; Zfp265; Znf265
Summary
Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human ZRANB2 (zinc finger RANBP2-type containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 33.5), CNS E18 (RPKM 33.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Zranb2 in Genome Data Viewer
Location:
3 H4; 3 81.29 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (157239749..157254029)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (157534120..157548390)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09370 Neighboring gene predicted gene 5983 Neighboring gene STARR-seq mESC enhancer starr_09371 Neighboring gene RIKEN cDNA 4930592C13 gene Neighboring gene STARR-seq mESC enhancer starr_09372 Neighboring gene STARR-positive B cell enhancer mm9_chr3:157228208-157228509 Neighboring gene microRNA 186 Neighboring gene STARR-seq mESC enhancer starr_09373 Neighboring gene STARR-seq mESC enhancer starr_09375 Neighboring gene prostaglandin E receptor 3 (subtype EP3) Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:157279973-157280264 Neighboring gene STARR-seq mESC enhancer starr_09378 Neighboring gene predicted gene 5550

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZRANB2: structural and functional insights into a novel splicing protein. Mangs AH, et al. Int J Biochem Cell Biol, 2008. PMID 17905639
  2. Expression pattern and splicing function of mouse ZNF265. Li J, et al. Neurochem Res, 2008 Mar. PMID 17805964
  3. Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling. Ohte S, et al. J Cell Biochem, 2012 Mar. PMID 22021003
  4. Characterization of a family of RanBP2-type zinc fingers that can recognize single-stranded RNA. Nguyen CD, et al. J Mol Biol, 2011 Mar 25. PMID 21256132
  5. Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene. Adams DJ, et al. Cytogenet Cell Genet, 2000. PMID 10773668

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger Ran-binding domain-containing protein 2
Names
zinc finger protein 265
zinc finger, splicing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355381.2 → NP_001342310.1  zinc finger Ran-binding domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC141480
    Related
    ENSMUSP00000029831.10, ENSMUST00000029831.16

  2. NM_001355386.2 → NP_001342315.1  zinc finger Ran-binding domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC141480
    Consensus CDS
    CCDS89715.1
    UniProtKB/TrEMBL
    D3Z4U0
    Related
    ENSMUSP00000101672.3, ENSMUST00000106057.8
    Conserved Domains (2) summary
    smart00547
    Location:67 → 91
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:13 → 34
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

  3. NM_001410610.1 → NP_001397539.1  zinc finger Ran-binding domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC141480

  4. NM_001410611.1 → NP_001397540.1  zinc finger Ran-binding domain-containing protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC141480

  5. NM_001410612.1 → NP_001397541.1  zinc finger Ran-binding domain-containing protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC141480

  6. NM_001410613.1 → NP_001397542.1  zinc finger Ran-binding domain-containing protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC141480

  7. NM_001410614.1 → NP_001397543.1  zinc finger Ran-binding domain-containing protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC141480

  8. NM_001410615.1 → NP_001397544.1  zinc finger Ran-binding domain-containing protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC141480

  9. NM_001410616.1 → NP_001397545.1  zinc finger Ran-binding domain-containing protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC141480

  10. NM_001410617.1 → NP_001397546.1  zinc finger Ran-binding domain-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC141480

  11. NM_001410618.1 → NP_001397547.1  zinc finger Ran-binding domain-containing protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC141480

  12. NM_001410619.1 → NP_001397548.1  zinc finger Ran-binding domain-containing protein 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC141480
    Related
    ENSMUSP00000101678.4, ENSMUST00000106063.6

  13. NM_017381.4 → NP_059077.1  zinc finger Ran-binding domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_059077.1

    Status: VALIDATED

    Source sequence(s)
    AC141480
    Consensus CDS
    CCDS51100.1
    UniProtKB/Swiss-Prot
    Q3TI29, Q3TLF5, Q3TUB7, Q3UD16, Q9R020
    UniProtKB/TrEMBL
    B2RRT9, D3Z4T9
    Related
    ENSMUSP00000101673.3, ENSMUST00000106058.8
    Conserved Domains (2) summary
    smart00547
    Location:67 → 91
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:13 → 34
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    157239749..157254029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319646.3 → XP_017175135.1  zinc finger Ran-binding domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    D3Z4U0
    Conserved Domains (2) summary
    smart00547
    Location:67 → 91
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:13 → 34
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R020.2 GenPept UniProtKB/Swiss-Prot:Q9R020

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