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ZRANB2 zinc finger RANBP2-type containing 2 [ Homo sapiens (human) ]

Gene ID: 9406, updated on 12-Oct-2019

Summary

Official Symbol
ZRANB2provided by HGNC
Official Full Name
zinc finger RANBP2-type containing 2provided by HGNC
Primary source
HGNC:HGNC:13058
See related
Ensembl:ENSG00000132485 MIM:604347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIS; ZIS1; ZIS2; ZNF265
Expression
Ubiquitous expression in endometrium (RPKM 47.3), lymph node (RPKM 37.7) and 25 other tissues See more
Orthologs

Genomic context

See ZRANB2 in Genome Data Viewer
Location:
1p31.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (71063291..71081035, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (71528974..71546972, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724572 Neighboring gene uncharacterized LOC107985517 Neighboring gene prostaglandin E receptor 3 Neighboring gene uncharacterized LOC105378795 Neighboring gene ZRANB2 antisense RNA 1 Neighboring gene ZRANB2 antisense RNA 2 (head to head) Neighboring gene microRNA 186 Neighboring gene neuronal growth regulator 1 Neighboring gene NEGR1 intronic transcript 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41119, DKFZp686J1831, DKFZp686N09117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
RNA binding HDA PubMed 
lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
zinc finger Ran-binding domain-containing protein 2
Names
zinc finger protein 265
zinc finger, RAN-binding domain containing 2
zinc-finger, splicing

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005455.5NP_005446.2  zinc finger Ran-binding domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_005446.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, which results in an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AL136945, AL512443, BC039814, BU677906, DA523601
    Consensus CDS
    CCDS660.1
    UniProtKB/Swiss-Prot
    O95218
    Related
    ENSP00000254821.6, ENST00000254821.10
    Conserved Domains (2) summary
    smart00547
    Location:6791
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:1334
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  2. NM_203350.3NP_976225.1  zinc finger Ran-binding domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_976225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AF065391, AL512443, BC033648, BU677906, DA523601
    Consensus CDS
    CCDS659.1
    UniProtKB/Swiss-Prot
    O95218
    Related
    ENSP00000359958.3, ENST00000370920.8
    Conserved Domains (2) summary
    smart00547
    Location:6791
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:1334
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    71063291..71081035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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