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Oaz3 ornithine decarboxylase antizyme 3 [ Mus musculus (house mouse) ]

Gene ID: 53814, updated on 1-Mar-2024

Summary

Official Symbol
Oaz3provided by MGI
Official Full Name
ornithine decarboxylase antizyme 3provided by MGI
Primary source
MGI:MGI:1858170
See related
Ensembl:ENSMUSG00000028141 AllianceGenome:MGI:1858170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AZ3; Az-3; Oaz-t
Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. This transcript initiates translation from a non-AUG (CUG) codon that is highly conserved among the antizyme 3 orthologs. [provided by RefSeq, Dec 2014]
Expression
Restricted expression toward testis adult (RPKM 1411.8) See more
Orthologs
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Genomic context

See Oaz3 in Genome Data Viewer
Location:
3 F2.1; 3 40.66 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94340694..94343958, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (94433387..94436651, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 4 Neighboring gene RIKEN cDNA 1700040D17 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:94216846-94217147 Neighboring gene tudor and KH domain containing protein Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene 40S ribosomal protein S2-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ankyrin repeat binding ISO
Inferred from Sequence Orthology
more info
 
enables ornithine decarboxylase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ornithine decarboxylase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ornithine decarboxylase inhibitor activity IGI
Inferred from Genetic Interaction
more info
 
enables ornithine decarboxylase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ornithine decarboxylase antizyme 3
Names
ODC-Az 3
antizyme 3
testis specific ornithine decarboxylase antizyme

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016901.3NP_058597.2  ornithine decarboxylase antizyme 3

    See identical proteins and their annotated locations for NP_058597.2

    Status: REVIEWED

    Source sequence(s)
    AC122808, AF175297, AI449747
    Consensus CDS
    CCDS84654.1
    UniProtKB/Swiss-Prot
    Q9R109, Q9WVT4
    UniProtKB/TrEMBL
    A0A0G2JF96
    Related
    ENSMUSP00000143080.3, ENSMUST00000199678.4
    Conserved Domains (1) summary
    pfam02100
    Location:138234
    ODC_AZ; Ornithine decarboxylase antizyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    94340694..94343958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)