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OAZ3 ornithine decarboxylase antizyme 3 [ Homo sapiens (human) ]

Gene ID: 51686, updated on 17-Jun-2019

Summary

Official Symbol
OAZ3provided by HGNC
Official Full Name
ornithine decarboxylase antizyme 3provided by HGNC
Primary source
HGNC:HGNC:8097
See related
Ensembl:ENSG00000143450 MIM:605138
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AZ3; OAZ-t; TISP15
Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Dec 2014]
Expression
Biased expression in testis (RPKM 63.7) and prostate (RPKM 6.3) See more
Orthologs

Genomic context

See OAZ3 in Genome Data Viewer
Location:
1q21.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151762969..151771330)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151735445..151743806)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 662, pseudogene Neighboring gene ribosomal protein S11 pseudogene 3 Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene tudor and KH domain containing Neighboring gene chloride nucleotide-sensitive channel 1A pseudogene Neighboring gene TDRKH antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Metabolism of polyamines, organism-specific biosystem (from REACTOME)
    Metabolism of polyamines, organism-specific biosystemPolyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that ar...
  • Regulation of ornithine decarboxylase (ODC), organism-specific biosystem (from REACTOME)
    Regulation of ornithine decarboxylase (ODC), organism-specific biosystemPolyamines increase the production of antizyme (AZ). The carboxy-terminal half of antizyme interacts with ODC, generating an inactive AZ:ODC heterodimer complex. A carboxy-terminal domain of ODC is ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ornithine decarboxylase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ornithine decarboxylase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
ornithine decarboxylase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
putrescine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of polyamine transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
putrescine transport IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular amino acid metabolic process TAS
Traceable Author Statement
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ornithine decarboxylase antizyme 3
Names
ODC-Az 3
antizyme 3
testicular secretory protein Li 31

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134939.1NP_001128411.1  ornithine decarboxylase antizyme 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation from an AUG start codon, compared to variant 1. The resulting isoform (2) is shorter with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF175296, BC073949
    Consensus CDS
    CCDS58028.1
    UniProtKB/Swiss-Prot
    Q9UMX2
    UniProtKB/TrEMBL
    A0A0G2JH29
    Related
    ENSP00000313922.5, ENST00000321531.10
    Conserved Domains (2) summary
    pfam02100
    Location:87178
    ODC_AZ; Ornithine decarboxylase antizyme
    cl19115
    Location:6794
    Cupredoxin; Cupredoxin superfamily
  2. NM_001301371.1NP_001288300.1  ornithine decarboxylase antizyme 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation from an AUG start codon, compared to variant 1. The resulting isoform (3) is shorter with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC073949, BI830988
    Consensus CDS
    CCDS76216.1
    UniProtKB/Swiss-Prot
    Q9UMX2
    UniProtKB/TrEMBL
    H0Y7Y4
    Related
    ENSP00000415904.2, ENST00000453029.2
    Conserved Domains (2) summary
    pfam02100
    Location:100191
    ODC_AZ; Ornithine decarboxylase antizyme
    cl19115
    Location:80107
    Cupredoxin; Cupredoxin superfamily
  3. NM_016178.2NP_057262.2  ornithine decarboxylase antizyme 3 isoform 1

    See identical proteins and their annotated locations for NP_057262.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) initiates translation from a non-AUG (CUG) start codon, and encodes the longest isoform (1).
    Source sequence(s)
    AF175296, BC073949
    Consensus CDS
    CCDS81378.1
    UniProtKB/Swiss-Prot
    Q9UMX2
    Related
    ENSP00000383784.2, ENST00000400999.6
    Conserved Domains (2) summary
    pfam02100
    Location:132223
    ODC_AZ; Ornithine decarboxylase antizyme
    cl19115
    Location:112139
    Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151762969..151771330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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