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S1PR5 sphingosine-1-phosphate receptor 5 [ Homo sapiens (human) ]

Gene ID: 53637, updated on 12-Aug-2018

Summary

Official Symbol
S1PR5provided by HGNC
Official Full Name
sphingosine-1-phosphate receptor 5provided by HGNC
Primary source
HGNC:HGNC:14299
See related
Ensembl:ENSG00000180739 MIM:605146; Vega:OTTHUMG00000180581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG8; S1P5; Edg-8; SPPR-1; SPPR-2
Summary
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Expression
Biased expression in skin (RPKM 5.9), bone marrow (RPKM 5.0) and 10 other tissues See more
Orthologs

Genomic context

See S1PR5 in Genome Data Viewer
Location:
19p13.2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (10512742..10517992, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10623418..10628668, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4A Neighboring gene kelch like ECH associated protein 1 Neighboring gene RNA, U7 small nuclear 140 pseudogene Neighboring gene autophagy related 4D cysteine peptidase Neighboring gene microRNA 1238

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sphingosine-1-phosphate receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
sphingosine-1-phosphate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sphingosine 1-phosphate receptor 5
Names
S1P receptor 5
S1P receptor Edg-8
endothelial differentiation G-protein-coupled receptor 8
endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
sphingosine 1-phosphate receptor EDG8
sphingosine 1-phosphate receptor Edg-8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166215.1NP_001159687.1  sphingosine 1-phosphate receptor 5

    See identical proteins and their annotated locations for NP_001159687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC011461, AF331840, BC034703, DA866378, DB013424
    Consensus CDS
    CCDS12240.1
    UniProtKB/Swiss-Prot
    Q9H228
    Related
    ENSP00000416915.2, OTTHUMP00000264673, ENST00000439028.3, OTTHUMT00000452015
    Conserved Domains (1) summary
    cd15348
    Location:37317
    7tmA_S1PR5_Edg8; sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_030760.4NP_110387.1  sphingosine 1-phosphate receptor 5

    See identical proteins and their annotated locations for NP_110387.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC011461, AF331840, BC034703, DA747912
    Consensus CDS
    CCDS12240.1
    UniProtKB/Swiss-Prot
    Q9H228
    Related
    ENSP00000328472.3, OTTHUMP00000264672, ENST00000333430.5, OTTHUMT00000452014
    Conserved Domains (1) summary
    cd15348
    Location:37317
    7tmA_S1PR5_Edg8; sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    10512742..10517992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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