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S1pr5 sphingosine-1-phosphate receptor 5 [ Mus musculus (house mouse) ]

Gene ID: 94226, updated on 8-Dec-2022


Official Symbol
S1pr5provided by MGI
Official Full Name
sphingosine-1-phosphate receptor 5provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000045087 AllianceGenome:MGI:2150641
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Edg8; S1P5; lpB4
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; genital tubercle; liver; sensory organ; and unsegmented mesenchyme. Orthologous to human S1PR5 (sphingosine-1-phosphate receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
Biased expression in cerebellum adult (RPKM 10.8), stomach adult (RPKM 9.4) and 11 other tissues See more
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Genomic context

See S1pr5 in Genome Data Viewer
9; 9 A3
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21154213..21159739, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21242917..21248443, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36118 Neighboring gene phosphodiesterase 4A, cAMP specific Neighboring gene kelch-like ECH-associated protein 1 Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog Neighboring gene cyclin dependent kinase inhibitor 2D

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
enables sphingosine-1-phosphate receptor activity IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
located_in plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
sphingosine 1-phosphate receptor 5
S1P receptor 5
S1P receptor Edg-8
endothelial differentiation G-protein-coupled receptor 8
endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
lysophospholipid receptor B4
sphingosine 1-phosphate receptor Edg-8
sphingosine-1-phosphate receptor LPB4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053190.2NP_444420.1  sphingosine 1-phosphate receptor 5

    See identical proteins and their annotated locations for NP_444420.1

    Status: VALIDATED

    Source sequence(s)
    AI848371, AI852113, AK081126, BY736639
    Consensus CDS
    Q91X56, Q99MN8
    ENSMUSP00000113843.2, ENSMUST00000122088.2
    Conserved Domains (1) summary
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000075.7 Reference GRCm39 C57BL/6J

    21154213..21159739 complement
    GenBank, FASTA, Sequence Viewer (Graphics)