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PLSCR1 phospholipid scramblase 1 [ Homo sapiens (human) ]

Gene ID: 5359, updated on 12-Oct-2019

Summary

Official Symbol
PLSCR1provided by HGNC
Official Full Name
phospholipid scramblase 1provided by HGNC
Primary source
HGNC:HGNC:9092
See related
Ensembl:ENSG00000188313 MIM:604170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MMTRA1B
Expression
Ubiquitous expression in appendix (RPKM 43.5), gall bladder (RPKM 33.7) and 25 other tissues See more
Orthologs

Genomic context

See PLSCR1 in Genome Data Viewer
Location:
3q24
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (146515178..146544805, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (146232967..146262628, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phospholipid scramblase 4 pseudogene Neighboring gene phospholipid scramblase 2 Neighboring gene RNA, U6 small nuclear 428, pseudogene Neighboring gene phospholipid scramblase family member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of phospholipid scramblase 1 (PLSCR1) by shRNA enhances the levels of gag mRNA in an HIV-1-infected MOLT-4 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Overexpression of PLSCR1 inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR and reduces the nuclear translocation of Tat PubMed
tat Human phospholipid scramblase 1 (PLSCR1) directly interacts with HIV-1 Tat both in vitro and in vivo through amino acids 160-250 of PLSCR1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CD4 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
SH3 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
phospholipid scramblase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acute-phase response ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylserine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipid scrambling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid scrambling IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of Fc receptor mediated stimulatory signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mast cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to interferon-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phospholipid scramblase 1
Names
PL scramblase 1
ca(2+)-dependent phospholipid scramblase 1
erythrocyte phospholipid scramblase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363872.1NP_001350801.1  phospholipid scramblase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC069528, AC116544
    Consensus CDS
    CCDS87153.1
    Related
    ENSP00000417792.1, ENST00000487389.5
    Conserved Domains (2) summary
    pfam03803
    Location:79300
    Scramblase; Scramblase
    cl27975
    Location:1590
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
  2. NM_001363874.1NP_001350803.1  phospholipid scramblase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC069528, AC116544
    Consensus CDS
    CCDS87152.1
    Conserved Domains (1) summary
    pfam03803
    Location:22226
    Scramblase; Scramblase
  3. NM_021105.3NP_066928.1  phospholipid scramblase 1 isoform 1

    See identical proteins and their annotated locations for NP_066928.1

    Status: VALIDATED

    Source sequence(s)
    AF098642, BC032718
    Consensus CDS
    CCDS3135.1
    UniProtKB/Swiss-Prot
    O15162
    Related
    ENSP00000345494.4, ENST00000342435.9
    Conserved Domains (2) summary
    pfam03803
    Location:86307
    Scramblase; Scramblase
    cl23807
    Location:20100
    WWbp; WW-domain ligand protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    146515178..146544805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247538.3XP_005247595.1  phospholipid scramblase 1 isoform X4

    See identical proteins and their annotated locations for XP_005247595.1

    UniProtKB/Swiss-Prot
    O15162
    Related
    ENSP00000411675.2, ENST00000448787.6
    Conserved Domains (1) summary
    pfam03803
    Location:22226
    Scramblase; Scramblase
  2. XM_011512906.2XP_011511208.1  phospholipid scramblase 1 isoform X4

    See identical proteins and their annotated locations for XP_011511208.1

    UniProtKB/Swiss-Prot
    O15162
    Conserved Domains (1) summary
    pfam03803
    Location:22226
    Scramblase; Scramblase
  3. XM_017006629.1XP_016862118.1  phospholipid scramblase 1 isoform X2

    UniProtKB/Swiss-Prot
    O15162
    Conserved Domains (2) summary
    pfam03803
    Location:86307
    Scramblase; Scramblase
    cl23807
    Location:20100
    WWbp; WW-domain ligand protein
  4. XM_011512904.1XP_011511206.1  phospholipid scramblase 1 isoform X2

    See identical proteins and their annotated locations for XP_011511206.1

    UniProtKB/Swiss-Prot
    O15162
    Conserved Domains (2) summary
    pfam03803
    Location:86307
    Scramblase; Scramblase
    cl23807
    Location:20100
    WWbp; WW-domain ligand protein
  5. XM_017006628.1XP_016862117.1  phospholipid scramblase 1 isoform X1

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