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PLSCR1 phospholipid scramblase 1 [ Homo sapiens (human) ]

Gene ID: 5359, updated on 5-Sep-2021

Summary

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Official Symbol
PLSCR1provided by HGNC
Official Full Name
phospholipid scramblase 1provided by HGNC
Primary source
HGNC:HGNC:9092
See related
Ensembl:ENSG00000188313 MIM:604170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MMTRA1B
Expression
Ubiquitous expression in appendix (RPKM 43.5), gall bladder (RPKM 33.7) and 25 other tissues See more
Orthologs
all
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Genomic context

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See PLSCR1 in Genome Data Viewer
Location:
3q24
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (146515178..146544805, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (146232967..146262394, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phospholipid scramblase 4 pseudogene Neighboring gene phospholipid scramblase 2 Neighboring gene RNA, U6 small nuclear 428, pseudogene Neighboring gene phospholipid scramblase family member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interaction of phospholipid scramblase 1 with the Epstein-Barr virus protein BZLF1 represses BZLF1-mediated lytic gene transcription. Kusano S, et al. J Biol Chem, 2019 Oct 11. PMID 31434743, Free PMC Article
  2. [Effect of PLSCR1 on the Antiviral Activity of IFN against HBV in HepG2 Cells]. Li Q, et al. Bing Du Xue Bao, 2016 Nov. PMID 30004207
  3. Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells. Ahyayauch H, et al. Sci Rep, 2018 May 10. PMID 29748552, Free PMC Article
  4. Interactions stabilizing the C-terminal helix of human phospholipid scramblase 1 in lipid bilayers: A computational study. Venken T, et al. Biochim Biophys Acta Biomembr, 2017 Jul. PMID 28372945
  5. Phospholipid scramblase 1 as a critical node at the crossroad between autophagy and apoptosis in mantle cell lymphoma. Mastorci K, et al. Oncotarget, 2016 Jul 5. PMID 27248824, Free PMC Article

See all (108) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-628-5p inhibits invasion and migration of human pancreatic ductal adenocarcinoma via suppression of the AKT/NF-kappa B pathway.
    Title: MicroRNA-628-5p inhibits invasion and migration of human pancreatic ductal adenocarcinoma via suppression of the AKT/NF-kappa B pathway.
  2. Nuclear translocation of PLSCR1 activates STAT1 signaling in basal-like breast cancer.
    Title: Nuclear translocation of PLSCR1 activates STAT1 signaling in basal-like breast cancer.
  3. Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.
    Title: Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.
  4. Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study.
    Title: Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study.
  5. p53 controls the switch between autophagy and apoptosis through regulation of PLSCR1 in sodium selenite-treated leukemia cells.
    Title: p53 controls the switch between autophagy and apoptosis through regulation of PLSCR1 in sodium selenite-treated leukemia cells.
  6. Interaction of phospholipid scramblase 1 with the Epstein-Barr virus protein BZLF1 represses BZLF1-mediated lytic gene transcription
    Title: Interaction of phospholipid scramblase 1 with the Epstein-Barr virus protein BZLF1 represses BZLF1-mediated lytic gene transcription.
  7. Inhibition of PLSCR1 decreased the antiviral activity of IFN against HBV.
    Title: [Effect of PLSCR1 on the Antiviral Activity of IFN against HBV in HepG2 Cells].
  8. Data suggest that PLSCR1 is involved in viral entry; here, herpes simplex viruses activate PLSCR1 and up-regulate flipping of phosphatidylserines and AKT to outside of plasma membrane shortly following HSV-1 or HSV-2 exposure. (PLSCR1 = phospholipid scramblase 1; AKT = proto-oncogene c-Akt)
    Title: Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry.
  9. wogonoside promotes the expression of PLSCR1 and enhances its nuclear translocation and binding to the 1, 4, 5-trisphosphate receptor 1 (IP3R1) promoter in AML patient-derived primary cells. Wogonoside activates IP3R1, in turn, promotes release of Ca(2+) from endoplasmic reticulum, and eventually leads to cell differentiation.
    Title: PLSCR1/IP3R1/Ca<sup>2+</sup> axis contributes to differentiation of primary AML cells induced by wogonoside.
  10. Data indicate heterogeneous expression of phospholipid scramblase 1 (PLSCR1) and suggest its possible implication in the response to anticancer therapies, especially to drugs promoting protective autophagy.
    Title: Phospholipid scramblase 1 as a critical node at the crossroad between autophagy and apoptosis in mantle cell lymphoma.
Submit: New GeneRIF Correction See all GeneRIFs (60)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of phospholipid scramblase 1 (PLSCR1) by shRNA enhances the levels of gag mRNA in an HIV-1-infected MOLT-4 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Overexpression of PLSCR1 inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR and reduces the nuclear translocation of Tat PubMed
tat Human phospholipid scramblase 1 (PLSCR1) directly interacts with HIV-1 Tat both in vitro and in vivo through amino acids 160-250 of PLSCR1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CD4 receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables SH3 domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lead ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mercury ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phospholipid scramblase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables virus receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in acute-phase response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylserine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylserine exposure on apoptotic cell surface IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane phospholipid scrambling IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in plasma membrane phospholipid scrambling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in platelet activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of chromosome separation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of Fc receptor mediated stimulatory signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mast cell activation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to interferon-beta IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to lead ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in viral entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phospholipid scramblase 1
Names
PL scramblase 1
ca(2+)-dependent phospholipid scramblase 1
erythrocyte phospholipid scramblase
mg(2+)-dependent nuclease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363872.1 → NP_001350801.1  phospholipid scramblase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC069528, AC116544
    Consensus CDS
    CCDS87153.1
    Related
    ENSP00000417792.1, ENST00000487389.5
    Conserved Domains (2) summary
    pfam03803
    Location:79 → 300
    Scramblase; Scramblase
    cl27975
    Location:15 → 90
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

  2. NM_001363874.1 → NP_001350803.1  phospholipid scramblase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC069528, AC116544
    Consensus CDS
    CCDS87152.1
    Conserved Domains (1) summary
    pfam03803
    Location:22 → 226
    Scramblase; Scramblase

  3. NM_021105.3 → NP_066928.1  phospholipid scramblase 1 isoform 1

    See identical proteins and their annotated locations for NP_066928.1

    Status: VALIDATED

    Source sequence(s)
    AF098642, BC032718
    Consensus CDS
    CCDS3135.1
    UniProtKB/Swiss-Prot
    O15162
    Related
    ENSP00000345494.4, ENST00000342435.9
    Conserved Domains (2) summary
    pfam03803
    Location:86 → 307
    Scramblase; Scramblase
    cl23807
    Location:20 → 100
    WWbp; WW-domain ligand protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    146515178..146544805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247538.3 → XP_005247595.1  phospholipid scramblase 1 isoform X4

    See identical proteins and their annotated locations for XP_005247595.1

    UniProtKB/Swiss-Prot
    O15162
    Related
    ENSP00000411675.2, ENST00000448787.6
    Conserved Domains (1) summary
    pfam03803
    Location:22 → 226
    Scramblase; Scramblase

  2. XM_011512906.2 → XP_011511208.1  phospholipid scramblase 1 isoform X4

    See identical proteins and their annotated locations for XP_011511208.1

    UniProtKB/Swiss-Prot
    O15162
    Conserved Domains (1) summary
    pfam03803
    Location:22 → 226
    Scramblase; Scramblase

  3. XM_017006629.1 → XP_016862118.1  phospholipid scramblase 1 isoform X2

    UniProtKB/Swiss-Prot
    O15162
    Conserved Domains (2) summary
    pfam03803
    Location:86 → 307
    Scramblase; Scramblase
    cl23807
    Location:20 → 100
    WWbp; WW-domain ligand protein

  4. XM_011512904.1 → XP_011511206.1  phospholipid scramblase 1 isoform X2

    See identical proteins and their annotated locations for XP_011511206.1

    UniProtKB/Swiss-Prot
    O15162
    Conserved Domains (2) summary
    pfam03803
    Location:86 → 307
    Scramblase; Scramblase
    cl23807
    Location:20 → 100
    WWbp; WW-domain ligand protein

  5. XM_017006628.1 → XP_016862117.1  phospholipid scramblase 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15162.1 GenPept UniProtKB/Swiss-Prot:O15162

Gene LinkOut

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