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ATP6V0A1 ATPase H+ transporting V0 subunit a1 [ Homo sapiens (human) ]

Gene ID: 535, updated on 1-Jun-2020

Summary

Official Symbol
ATP6V0A1provided by HGNC
Official Full Name
ATPase H+ transporting V0 subunit a1provided by HGNC
Primary source
HGNC:HGNC:865
See related
Ensembl:ENSG00000033627 MIM:192130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
a1; Stv1; VPP1; Vph1; ATP6N1; ATP6N1A
Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 46.5), kidney (RPKM 12.3) and 23 other tissues See more
Orthologs

Genomic context

See ATP6V0A1 in Genome Data Viewer
Location:
17q21.2
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (42458874..42522579)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40610862..40674597)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene caveolae associated protein 1 Neighboring gene uncharacterized LOC102725238 Neighboring gene RNA, U7 small nuclear 97 pseudogene Neighboring gene microRNA 548at Neighboring gene microRNA 5010 Neighboring gene PTP4A2 pseudogene 1 Neighboring gene N-acetyl-alpha-glucosaminidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ATPase, H+ transporting, lysosomal V0 subunit a1 (ATP6V0A1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781J1951

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
phagosome acidification TAS
Traceable Author Statement
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
toxin transport IEA
Inferred from Electronic Annotation
more info
 
transferrin transport TAS
Traceable Author Statement
more info
 
vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vacuolar acidification TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosomal membrane TAS
Traceable Author Statement
more info
PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 
vacuolar proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vacuolar proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
V-type proton ATPase 116 kDa subunit a isoform 1; V-type proton ATPase 116 kDa subunit a
Names
ATPase, H+ transporting, lysosomal V0 subunit a1
ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD)
H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1
V-ATPase 116 kDa
clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit
vacuolar adenosine triphosphatase subunit Ac116
vacuolar proton pump subunit 1
vacuolar proton translocating ATPase 116 kDa subunit A
vacuolar-type H(+)-ATPase 115 kDa subunit
NP_001123492.1
NP_001123493.1
NP_001365451.1
NP_001365452.1
NP_001365459.1
NP_001365460.1
NP_001365461.1
NP_001365462.1
NP_001365463.1
NP_001365464.1
NP_001365465.1
NP_001365466.1
NP_001365467.1
NP_001365468.1
NP_001365469.1
NP_001365470.1
NP_001365471.1
NP_001365472.1
NP_001365473.1
NP_001365474.1
NP_001365475.1
NP_001365476.1
NP_001365477.1
NP_001365478.1
NP_001365479.1
NP_001365480.1
NP_001365481.1
NP_001365483.1
NP_001365485.1
NP_001365486.1
NP_005168.2
XP_016880261.1
XP_016880262.1
XP_016880263.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047037.1 RefSeqGene

    Range
    5035..68768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130020.3NP_001123492.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 2

    See identical proteins and their annotated locations for NP_001123492.1

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS45683.1
    UniProtKB/Swiss-Prot
    Q93050
    UniProtKB/TrEMBL
    Q53ET5, Q53X12, Q5CZH6
    Related
    ENSP00000264649.5, ENST00000264649.10
    Conserved Domains (1) summary
    pfam01496
    Location:27828
    V_ATPase_I; V-type ATPase 116kDa subunit family
  2. NM_001130021.3NP_001123493.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 1

    See identical proteins and their annotated locations for NP_001123493.1

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS45684.1
    UniProtKB/Swiss-Prot
    Q93050
    UniProtKB/TrEMBL
    Q53X12
    Related
    ENSP00000342951.3, ENST00000343619.8
    Conserved Domains (1) summary
    pfam01496
    Location:27827
    V_ATPase_I; V-type ATPase 116kDa subunit family
  3. NM_001378522.1NP_001365451.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  4. NM_001378523.1NP_001365452.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  5. NM_001378530.1NP_001365459.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  6. NM_001378531.1NP_001365460.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  7. NM_001378532.1NP_001365461.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  8. NM_001378533.1NP_001365462.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  9. NM_001378534.1NP_001365463.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  10. NM_001378535.1NP_001365464.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  11. NM_001378536.1NP_001365465.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  12. NM_001378537.1NP_001365466.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  13. NM_001378538.1NP_001365467.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Related
    ENSP00000466878.1, ENST00000585525.5
  14. NM_001378539.1NP_001365468.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  15. NM_001378540.1NP_001365469.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Related
    ENSP00000443991.1, ENST00000537728.5
  16. NM_001378541.1NP_001365470.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  17. NM_001378542.1NP_001365471.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  18. NM_001378543.1NP_001365472.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  19. NM_001378544.1NP_001365473.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  20. NM_001378545.1NP_001365474.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  21. NM_001378546.1NP_001365475.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  22. NM_001378547.1NP_001365476.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  23. NM_001378548.1NP_001365477.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  24. NM_001378549.1NP_001365478.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  25. NM_001378550.1NP_001365479.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  26. NM_001378551.1NP_001365480.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  27. NM_001378552.1NP_001365481.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  28. NM_001378554.1NP_001365483.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  29. NM_001378556.1NP_001365485.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  30. NM_001378557.1NP_001365486.1  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
  31. NM_005177.5NP_005168.2  V-type proton ATPase 116 kDa subunit a isoform 1 isoform 3

    See identical proteins and their annotated locations for NP_005168.2

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS11426.1
    UniProtKB/Swiss-Prot
    Q93050
    UniProtKB/TrEMBL
    Q53X12
    Related
    ENSP00000377415.2, ENST00000393829.6
    Conserved Domains (1) summary
    pfam01496
    Location:27821
    V_ATPase_I; V-type ATPase 116kDa subunit family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    42458874..42522579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024774.2XP_016880263.1  V-type proton ATPase 116 kDa subunit a isoform X9

  2. XM_017024772.2XP_016880261.1  V-type proton ATPase 116 kDa subunit a isoform X8

    Related
    ENSP00000446377.1, ENST00000544137.5
  3. XM_017024773.2XP_016880262.1  V-type proton ATPase 116 kDa subunit a isoform X8

RNA

  1. XR_002958025.1 RNA Sequence

  2. XR_001752538.2 RNA Sequence

  3. XR_934483.3 RNA Sequence

  4. XR_934484.3 RNA Sequence

  5. XR_001752540.2 RNA Sequence

  6. XR_002958026.1 RNA Sequence

  7. XR_002958027.1 RNA Sequence

  8. XR_002958028.1 RNA Sequence

  9. XR_001752539.1 RNA Sequence

  10. XR_002958029.1 RNA Sequence

  11. XR_002958030.1 RNA Sequence

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