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PLGLB2 plasminogen like B2 [ Homo sapiens (human) ]

Gene ID: 5342, updated on 22-Aug-2021

Summary

Official Symbol
PLGLB2provided by HGNC
Official Full Name
plasminogen like B2provided by HGNC
Primary source
HGNC:HGNC:9073
See related
Ensembl:ENSG00000125551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRGA; PLGLA; PLGP1; PLGP2; PLGLA1
Expression
Biased expression in liver (RPKM 70.9) and testis (RPKM 2.2) See more
Orthologs
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Genomic context

See PLGLB2 in Genome Data Viewer
Location:
2p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (87748087..87759476)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (88047606..88058995)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928214 Neighboring gene ANAPC1 pseudogene 4 Neighboring gene RANBP2 like and GRIP domain containing 2 Neighboring gene MT-ATP6 pseudogene 28 Neighboring gene MT-ATP8 pseudogene 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol 3-kinase catalytic subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of phosphatidylinositol 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
plasminogen-like protein B
Names
Plasminogen-like protein A
Plasminogen-like protein A1
plasminogen pseudogene 1
plasminogen-related protein A
plasminogen-related protein B
type B plasminogen related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002665.4NP_002656.1  plasminogen-like protein B precursor

    See identical proteins and their annotated locations for NP_002656.1

    Status: VALIDATED

    Source sequence(s)
    AC093616, BC005379
    Consensus CDS
    CCDS1999.1
    UniProtKB/Swiss-Prot
    Q02325
    Related
    ENSP00000352458.4, ENST00000359481.9
    Conserved Domains (1) summary
    cd01099
    Location:2296
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    87748087..87759476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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