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Chst3 carbohydrate sulfotransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 53374, updated on 5-Mar-2024

Summary

Official Symbol
Chst3provided by MGI
Official Full Name
carbohydrate sulfotransferase 3provided by MGI
Primary source
MGI:MGI:1858224
See related
Ensembl:ENSMUSG00000057337 AllianceGenome:MGI:1858224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C6ST; GST-0; C6ST-1
Summary
Enables chondroitin 6-sulfotransferase activity and proteoglycan sulfotransferase activity. Acts upstream of or within T cell homeostasis and chondroitin sulfate biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in trans-Golgi network. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and respiratory system. Used to study schizophrenia. Human ortholog(s) of this gene implicated in osteochondrodysplasia and spondyloepiphyseal dysplasia with congenital joint dislocations. Orthologous to human CHST3 (carbohydrate sulfotransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 18.8), mammary gland adult (RPKM 4.5) and 5 other tissues See more
Orthologs
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Genomic context

Location:
10 B4; 10 29.7 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (60017349..60057936, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (60181527..60222114, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 Neighboring gene microRNA 6906 Neighboring gene STARR-positive B cell enhancer ABC_E5138 Neighboring gene predicted gene, 51802 Neighboring gene STARR-seq mESC enhancer starr_26799 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59631170-59631353 Neighboring gene STARR-positive B cell enhancer ABC_E10611 Neighboring gene STARR-positive B cell enhancer mm9_chr10:59652431-59652731 Neighboring gene STARR-positive B cell enhancer ABC_E11440 Neighboring gene STARR-positive B cell enhancer mm9_chr10:59692925-59693225 Neighboring gene headcase homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2325 Neighboring gene STARR-seq mESC enhancer starr_26804 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59740166-59740349 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59747447-59747650 Neighboring gene prosaposin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chondroitin 6-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chondroitin 6-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chondroitin 6-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables keratan sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables proteoglycan sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables proteoglycan sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
carbohydrate sulfotransferase 3
Names
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
chondroitin 6-O-sulfotransferase 1
chondroitin 6-sulfotransferase
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
NP_001393954.1
NP_058083.3
XP_011241812.1
XP_011241815.1
XP_017169519.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001407025.1NP_001393954.1  carbohydrate sulfotransferase 3

    Status: VALIDATED

    Source sequence(s)
    AC155640
    UniProtKB/Swiss-Prot
    O88199, Q794I5
    Related
    ENSMUSP00000065010.7, ENSMUST00000068690.7
  2. NM_016803.4NP_058083.3  carbohydrate sulfotransferase 3

    Status: VALIDATED

    Source sequence(s)
    AC155640
    Consensus CDS
    CCDS23871.2
    UniProtKB/Swiss-Prot
    O88199, Q794I5
    Related
    ENSMUSP00000131532.2, ENSMUST00000167915.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    60017349..60057936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314030.2XP_017169519.1  carbohydrate sulfotransferase 3 isoform X1

    UniProtKB/TrEMBL
    G5E8X5
    Conserved Domains (1) summary
    pfam00685
    Location:265451
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_011243510.4XP_011241812.1  carbohydrate sulfotransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_011241812.1

    UniProtKB/TrEMBL
    G5E8X5
    Conserved Domains (1) summary
    pfam00685
    Location:265451
    Sulfotransfer_1; Sulfotransferase domain
  3. XM_011243513.4XP_011241815.1  carbohydrate sulfotransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_011241815.1

    UniProtKB/TrEMBL
    G5E8X5
    Conserved Domains (1) summary
    pfam00685
    Location:265451
    Sulfotransfer_1; Sulfotransferase domain