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CHST3 carbohydrate sulfotransferase 3 [ Homo sapiens (human) ]

Gene ID: 9469, updated on 3-May-2025
Official Symbol
CHST3provided by HGNC
Official Full Name
carbohydrate sulfotransferase 3provided by HGNC
Primary source
HGNC:HGNC:1971
See related
Ensembl:ENSG00000122863 MIM:603799; AllianceGenome:HGNC:1971
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD; C6ST; C6ST1
Summary
This gene encodes an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis. [provided by RefSeq, Mar 2009]
Expression
Broad expression in testis (RPKM 10.9), ovary (RPKM 8.0) and 21 other tissues See more
Orthologs
NEW
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Try the new Transcript table
See CHST3 in Genome Data Viewer
Location:
10q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (71964395..72013558)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (72835220..72884391)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73724153..73773316)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene prosaposin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73609267-73609766 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73610158-73610688 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73610689-73611219 Neighboring gene RNA, U7 small nuclear 38 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr10:73619612-73619846 Neighboring gene NFE2L2 motif-containing MPRA enhancers 43 and 138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73635755-73636635 Neighboring gene long intergenic non-protein coding RNA 3139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2467 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73665425-73665924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3525 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:73698038-73698194 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:73715248-73715463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2468 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:73716485-73716704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73729339-73729882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73729883-73730426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73733189-73733688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73738687-73739188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3527 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:73751377-73751550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73757484-73758436 Neighboring gene uncharacterized LOC124902448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73828839-73829346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73829527-73830028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73840535-73841319 Neighboring gene SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chondroitin 6-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chondroitin 6-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chondroitin 6-sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables chondroitin 6-sulfotransferase activity TAS
Traceable Author Statement
more info
 
enables proteoglycan sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
carbohydrate sulfotransferase 3
Names
C6ST-1
GST-0
carbohydrate (chondroitin 6) sulfotransferase 3
chondroitin 6 sulfotransferase 1
chondroitin 6-O-sulfotransferase 1
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
NP_004264.2
XP_006718138.1
XP_011538671.1
XP_047281978.1
XP_054223177.1
XP_054223178.1
XP_054223179.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012635.1 RefSeqGene

    Range
    5034..54197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004273.5NP_004264.2  carbohydrate sulfotransferase 3

    See identical proteins and their annotated locations for NP_004264.2

    Status: REVIEWED

    Source sequence(s)
    AB017915, AC022392, AI041015
    Consensus CDS
    CCDS7312.1
    UniProtKB/Swiss-Prot
    O75099, Q52M30, Q7LGC8
    Related
    ENSP00000362207.4, ENST00000373115.5
    Conserved Domains (1) summary
    pfam00685
    Location:265452
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    71964395..72013558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426022.1XP_047281978.1  carbohydrate sulfotransferase 3 isoform X1

    UniProtKB/Swiss-Prot
    O75099, Q52M30, Q7LGC8
  2. XM_006718075.5XP_006718138.1  carbohydrate sulfotransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006718138.1

    UniProtKB/Swiss-Prot
    O75099, Q52M30, Q7LGC8
    Conserved Domains (1) summary
    pfam00685
    Location:265452
    Sulfotransfer_1; Sulfotransferase domain
  3. XM_011540369.3XP_011538671.1  carbohydrate sulfotransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_011538671.1

    UniProtKB/Swiss-Prot
    O75099, Q52M30, Q7LGC8
    Conserved Domains (1) summary
    pfam00685
    Location:265452
    Sulfotransfer_1; Sulfotransferase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    72835220..72884391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367202.1XP_054223177.1  carbohydrate sulfotransferase 3 isoform X1

    UniProtKB/Swiss-Prot
    O75099, Q52M30, Q7LGC8
  2. XM_054367204.1XP_054223179.1  carbohydrate sulfotransferase 3 isoform X1

    UniProtKB/Swiss-Prot
    O75099, Q52M30, Q7LGC8
  3. XM_054367203.1XP_054223178.1  carbohydrate sulfotransferase 3 isoform X1

    UniProtKB/Swiss-Prot
    O75099, Q52M30, Q7LGC8