Format

Send to:

Choose Destination

CHST3 carbohydrate sulfotransferase 3 [ Homo sapiens (human) ]

Gene ID: 9469, updated on 11-Sep-2019

Summary

Official Symbol
CHST3provided by HGNC
Official Full Name
carbohydrate sulfotransferase 3provided by HGNC
Primary source
HGNC:HGNC:1971
See related
Ensembl:ENSG00000122863 MIM:603799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD; C6ST; C6ST1
Summary
This gene encodes an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis. [provided by RefSeq, Mar 2009]
Expression
Broad expression in testis (RPKM 10.9), ovary (RPKM 8.0) and 21 other tissues See more
Orthologs

Genomic context

See CHST3 in Genome Data Viewer
Location:
10q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (71964395..72013562)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73724120..73773322)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NFE2L2 motif-containing MPRA enhancers 43 and 138 Neighboring gene prosaposin Neighboring gene RNA, U7 small nuclear 38 pseudogene Neighboring gene SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene ribosomal protein L15 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chondroitin 6-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chondroitin 6-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
sulfotransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
chondroitin sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chondroitin sulfate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
chondroitin sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
sulfur compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfur compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carbohydrate sulfotransferase 3
Names
C6ST-1
GST-0
carbohydrate (chondroitin 6) sulfotransferase 3
chondroitin 6 sulfotransferase 1
chondroitin 6-O-sulfotransferase 1
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
NP_004264.2
XP_006718138.1
XP_011538671.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012635.1 RefSeqGene

    Range
    5034..54197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004273.5NP_004264.2  carbohydrate sulfotransferase 3

    See identical proteins and their annotated locations for NP_004264.2

    Status: REVIEWED

    Source sequence(s)
    AB017915, AC022392, AI041015
    Consensus CDS
    CCDS7312.1
    UniProtKB/Swiss-Prot
    Q7LGC8
    Related
    ENSP00000362207.4, ENST00000373115.5
    Conserved Domains (1) summary
    pfam00685
    Location:267452
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    71964395..72013562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718075.4XP_006718138.1  carbohydrate sulfotransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006718138.1

    UniProtKB/Swiss-Prot
    Q7LGC8
    Conserved Domains (1) summary
    pfam00685
    Location:267452
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_011540369.2XP_011538671.1  carbohydrate sulfotransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_011538671.1

    UniProtKB/Swiss-Prot
    Q7LGC8
    Conserved Domains (1) summary
    pfam00685
    Location:267452
    Sulfotransfer_1; Sulfotransferase domain
Support Center