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IL17D interleukin 17D [ Homo sapiens (human) ]

Gene ID: 53342, updated on 29-Mar-2018
Official Symbol
IL17Dprovided by HGNC
Official Full Name
interleukin 17Dprovided by HGNC
Primary source
HGNC:HGNC:5984
See related
Ensembl:ENSG00000172458 MIM:607587; Vega:OTTHUMG00000016521
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-17D
Summary
The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 13.7), ovary (RPKM 2.3) and 11 other tissues See more
Orthologs
See IL17D in Genome Data Viewer
Location:
13q12.11
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (20701105..20723100)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21276222..21297239)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 88 Neighboring gene solute carrier family 35 member E1 pseudogene 1 Neighboring gene RNA, U2 small nuclear 7, pseudogene Neighboring gene EEF1A lysine methyltransferase 1 Neighboring gene RAN, member RAS oncogene family pseudogene 8 Neighboring gene exportin 4

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic determinants of P wave duration and PR segment.
NHGRI GWA Catalog
GWAS of dental caries patterns in the permanent dentition.
NHGRI GWA Catalog
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
    IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL-17 signaling pathway, conserved biosystem (from KEGG)
    IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL17 signaling pathway, organism-specific biosystem (from WikiPathways)
    IL17 signaling pathway, organism-specific biosystemInterleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Th17 cell differentiation, organism-specific biosystem (from KEGG)
    Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Th17 cell differentiation, conserved biosystem (from KEGG)
    Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...

Markers

Homology

Clone Names

  • FLJ30846

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138284.1NP_612141.1  interleukin-17D precursor

    See identical proteins and their annotated locations for NP_612141.1

    Status: REVIEWED

    Source sequence(s)
    AY078238
    Consensus CDS
    CCDS9292.1
    UniProtKB/Swiss-Prot
    Q8TAD2
    Related
    ENSP00000302924.3, OTTHUMP00000018104, ENST00000304920.3, OTTHUMT00000044087
    Conserved Domains (1) summary
    pfam06083
    Location:89170
    IL17; Interleukin-17

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    20701105..20723100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266421.4XP_005266478.1  interleukin-17D isoform X1

    See identical proteins and their annotated locations for XP_005266478.1

    Conserved Domains (1) summary
    pfam06083
    Location:96177
    IL17; Interleukin-17
  2. XM_005266422.3XP_005266479.1  interleukin-17D isoform X2

    See identical proteins and their annotated locations for XP_005266479.1

    Conserved Domains (1) summary
    pfam06083
    Location:982
    IL17; Interleukin-17
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