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IL17D interleukin 17D [ Homo sapiens (human) ]

Gene ID: 53342, updated on 28-Jun-2021

Summary

Official Symbol
IL17Dprovided by HGNC
Official Full Name
interleukin 17Dprovided by HGNC
Primary source
HGNC:HGNC:5984
See related
Ensembl:ENSG00000172458 MIM:607587
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-17D
Summary
The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 13.7), ovary (RPKM 2.3) and 11 other tissues See more
Orthologs
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Genomic context

See IL17D in Genome Data Viewer
Location:
13q12.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (20701513..20723098)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21275652..21297237)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 88 Neighboring gene solute carrier family 35 member E1 pseudogene 1 Neighboring gene RNA, U2 small nuclear 7, pseudogene Neighboring gene EEF1A lysine methyltransferase 1 Neighboring gene RAN pseudogene 8 Neighboring gene exportin 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic determinants of P wave duration and PR segment.
GeneReviews: Not available
GWAS of dental caries patterns in the permanent dentition.
GeneReviews: Not available

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • FLJ30846

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385221.1NP_001372150.1  interleukin-17D isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Isoforms a and b are the same length but differ in their N-termini.
    Source sequence(s)
    AL161772, AL512652
    Conserved Domains (1) summary
    pfam06083
    Location:96177
    IL17; Interleukin-17
  2. NM_001385222.1NP_001372151.1  interleukin-17D isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (b). Isoforms a and b are the same length but differ in their N-termini.
    Source sequence(s)
    AL161772, AL512652
    Conserved Domains (1) summary
    pfam06083
    Location:96177
    IL17; Interleukin-17
  3. NM_001385223.1NP_001372152.1  interleukin-17D isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
    Source sequence(s)
    AL161772, AL512652
    Conserved Domains (1) summary
    pfam06083
    Location:89170
    IL17; Interleukin-17
  4. NM_001385224.1NP_001372153.1  interleukin-17D isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
    Source sequence(s)
    AL161772, AL512652
    Related
    ENSP00000508385.1, ENST00000682841.1
    Conserved Domains (1) summary
    pfam06083
    Location:89170
    IL17; Interleukin-17
  5. NM_001385225.1NP_001372154.1  interleukin-17D isoform d

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL512652
    Conserved Domains (1) summary
    pfam06083
    Location:1186
    IL17; Interleukin-17
  6. NM_001386973.1NP_001373902.1  interleukin-17D isoform e

    Status: REVIEWED

    Source sequence(s)
    AL512652
    Conserved Domains (1) summary
    pfam06083
    Location:982
    IL17; Interleukin-17
  7. NM_138284.2NP_612141.1  interleukin-17D isoform c precursor

    See identical proteins and their annotated locations for NP_612141.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
    Source sequence(s)
    AL161772, AL512652
    Consensus CDS
    CCDS9292.1
    UniProtKB/Swiss-Prot
    Q8TAD2
    Related
    ENSP00000302924.3, ENST00000304920.3
    Conserved Domains (1) summary
    pfam06083
    Location:89170
    IL17; Interleukin-17

RNA

  1. NR_169590.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL512652
  2. NR_169591.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL512652

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    20701513..20723098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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