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Nxf1 nuclear RNA export factor 1 [ Mus musculus (house mouse) ]

Gene ID: 53319, updated on 4-May-2024

Summary

Official Symbol
Nxf1provided by MGI
Official Full Name
nuclear RNA export factor 1provided by MGI
Primary source
MGI:MGI:1858330
See related
Ensembl:ENSMUSG00000010097 AllianceGenome:MGI:1858330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tap; Mvb1; Mex67
Summary
Enables mRNA binding activity. Acts upstream of or within poly(A)+ mRNA export from nucleus. Located in nuclear inclusion body. Part of nuclear pore. Is expressed in several structures, including central nervous system; genitourinary system; liver; sensory organ; and spleen. Orthologous to human NXF1 (nuclear RNA export factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 63.9), bladder adult (RPKM 56.8) and 28 other tissues See more
Orthologs
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Genomic context

See Nxf1 in Genome Data Viewer
Location:
19 A; 19 5.5 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8734467..8748274)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8757103..8770910)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene syntaxin 5A Neighboring gene microRNA 6992 Neighboring gene RIKEN cDNA 1700023D09 gene Neighboring gene STARR-seq mESC enhancer starr_45493 Neighboring gene transmembrane protein 223 Neighboring gene transmembrane protein 179B Neighboring gene TATA-box binding protein associated factor 6 like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within poly(A)+ mRNA export from nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear RNA export factor complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear RNA export factor 1
Names
Mex 67 homolog
mRNA export factor TAP
modifier of vibrator 1
nuclear RNA export factor 1 homolog
tip associated protein
tip associating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276704.1NP_001263633.1  nuclear RNA export factor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal segment and transcription extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK143640
    Consensus CDS
    CCDS70930.1
    UniProtKB/TrEMBL
    V9GXF3
    Related
    ENSMUSP00000139124.2, ENSMUST00000184970.9
    Conserved Domains (4) summary
    sd00035
    Location:223265
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam09162
    Location:115197
    Tap-RNA_bind; Tap, RNA-binding
    pfam12799
    Location:290328
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:264326
    LRR_8; Leucine rich repeat
  2. NM_016813.2NP_058093.2  nuclear RNA export factor 1 isoform 1

    See identical proteins and their annotated locations for NP_058093.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC005594
    Consensus CDS
    CCDS29543.1
    UniProtKB/Swiss-Prot
    O88985, Q3TJA5, Q99JX7
    UniProtKB/TrEMBL
    Q8BP60
    Related
    ENSMUSP00000010241.7, ENSMUST00000010241.14
    Conserved Domains (6) summary
    smart00804
    Location:555617
    TAP_C; C-terminal domain of vertebrate Tap protein
    cd00780
    Location:381537
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    sd00035
    Location:223265
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam09162
    Location:115197
    Tap-RNA_bind; Tap, RNA-binding
    pfam12799
    Location:290328
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:264326
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8734467..8748274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)