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PLAUR plasminogen activator, urokinase receptor [ Homo sapiens (human) ]

Gene ID: 5329, updated on 3-Apr-2024

Summary

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Official Symbol
PLAURprovided by HGNC
Official Full Name
plasminogen activator, urokinase receptorprovided by HGNC
Primary source
HGNC:HGNC:9053
See related
Ensembl:ENSG00000011422 MIM:173391; AllianceGenome:HGNC:9053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD87; UPAR; URKR; U-PAR
Summary
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 100.8), gall bladder (RPKM 18.1) and 5 other tissues See more
Orthologs
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Genomic context

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See PLAUR in Genome Data Viewer
Location:
19q13.31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43646095..43670169, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46467757..46492325, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44150247..44174321, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 428 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44123140-44123790 Neighboring gene uncharacterized LOC105372411 Neighboring gene serine/arginine repetitive matrix 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44127716-44128216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44128217-44128717 Neighboring gene cell adhesion molecule 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10725 Neighboring gene RNA, 7SL, cytoplasmic 368, pseudogene Neighboring gene uncharacterized LOC124904724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14732 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44183469-44183968 Neighboring gene phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44204596-44205096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44220201-44220701 Neighboring gene immunity related GTPase cinema

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Circulating Soluble Urokinase Plasminogen Activator Receptor as a Predictive Indicator for COVID-19-Associated Acute Kidney Injury and Mortality: Clinical and Bioinformatics Analysis. Abdellatif HAA, et al. Int J Mol Sci, 2023 Apr 13. PMID 37108340, Free PMC Article
  2. PLAUR splicing pattern in hereditary angioedema patients' monocytes and macrophages. Ballonová L, et al. Mol Biol Rep, 2023 Jun. PMID 37086298
  3. Urokinase plasminogen activator surface receptor restricts HIV-1 replication by blocking virion release from the cell membrane. Pang H, et al. Proc Natl Acad Sci U S A, 2023 Jan 17. PMID 36638209, Free PMC Article
  4. The Association of PLAUR Genotype and Soluble suPAR Serum Level with COVID-19-Related Lung Damage Severity. Nekrasova LA, et al. Int J Mol Sci, 2022 Dec 19. PMID 36555850, Free PMC Article
  5. Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis. Hindy G, et al. J Clin Invest, 2022 Dec 15. PMID 36194491, Free PMC Article

See all (629) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. uPAR (PLAUR) Marks Two Intra-Tumoral Subtypes of Glioblastoma: Insights from Single-Cell RNA Sequencing.
    Title: uPAR (PLAUR) Marks Two Intra-Tumoral Subtypes of Glioblastoma: Insights from Single-Cell RNA Sequencing.
  2. Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response.
    Title: Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response.
  3. Soluble urokinase plasminogen activator receptor (suPAR) in bronchoalveolar fluid and blood in critically ill patients-a prospective cohort study.
    Title: Soluble urokinase plasminogen activator receptor (suPAR) in bronchoalveolar fluid and blood in critically ill patients-a prospective cohort study.
  4. Soluble urokinase plasminogen activator receptor, platelet aggregation, and carotid plaque thickness in diabetes: A cross-sectional analysis.
    Title: Soluble urokinase plasminogen activator receptor, platelet aggregation, and carotid plaque thickness in diabetes: A cross-sectional analysis.
  5. Soluble urokinase plasminogen activator receptor in vaginally collected amniotic fluid predicting fetal inflammatory response syndrome: a prospective cohort study.
    Title: Soluble urokinase plasminogen activator receptor in vaginally collected amniotic fluid predicting fetal inflammatory response syndrome: a prospective cohort study.
  6. A case of mosaic deletion of paternally-inherited PLAGL1 and two cases of upd(6)mat add to evidence for PLAGL1 under-expression as a cause of growth restriction.
    Title: A case of mosaic deletion of paternally-inherited PLAGL1 and two cases of upd(6)mat add to evidence for PLAGL1 under-expression as a cause of growth restriction.
  7. Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression.
    Title: Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression.
  8. Plasma IL-6, TREM1, uPAR, and IL6/IL8 biomarkers increment further witnessing the chronic inflammation in type 2 diabetes.
    Title: Plasma IL-6, TREM1, uPAR, and IL6/IL8 biomarkers increment further witnessing the chronic inflammation in type 2 diabetes.
  9. SuPAR mediates viral response proteinuria by rapidly changing podocyte function.
    Title: SuPAR mediates viral response proteinuria by rapidly changing podocyte function.
  10. YY1 regulates the proliferation and invasion of triple-negative breast cancer via activating PLAUR.
    Title: YY1 regulates the proliferation and invasion of triple-negative breast cancer via activating PLAUR.
Submit: New GeneRIF Correction See all GeneRIFs (557)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of plasminogen activator, urokinase receptor (PLAUR) in human B cells PubMed
capsid gag A peptide (Ch7) derived from HIV-1 Capsid (amino acids 232-238) has been shown to have immunosuppressive effects through a possible interaction with the Plasminogen Receptor, indicating a role for Capsid in the immunosuppressive effects of HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables urokinase plasminogen activator receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in chemotaxis TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of homotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of fibrinolysis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of plasminogen activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of proteolysis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in urokinase plasminogen activator signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in external side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extrinsic component of membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of protein complex involved in cell-matrix adhesion IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of serine-type endopeptidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in specific granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
urokinase plasminogen activator surface receptor
Names
monocyte activation antigen Mo3
u-plasminogen activator receptor form 2
urokinase-type plasminogen activator (uPA) receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032898.1 RefSeqGene

    Range
    5178..26768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_637

mRNA and Protein(s)

  1. NM_001005376.3 → NP_001005376.1  urokinase plasminogen activator surface receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001005376.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1. Variant 2 encodes the shortest isoform (2), also called suPLAUR, which is the soluble form of this protein. Isoform 2 lacks one of three LU (Ly-6 antigen/uPA receptor-like) domains, compared to isoform 1.
    Source sequence(s)
    AI801128, AI912302, CA495321, X74039
    Consensus CDS
    CCDS33041.1
    UniProtKB/TrEMBL
    Q9UPI5
    Related
    ENSP00000342049.2, ENST00000339082.7
    Conserved Domains (2) summary
    smart00134
    Location:115 → 202
    LU; Ly-6 antigen / uPA receptor -like domain
    cl10471
    Location:23 → 101
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

  2. NM_001005377.3 → NP_001005377.1  urokinase plasminogen activator surface receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001005377.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one exon in the coding region and encodes an isoleucine rather than a valine following the splice site, compared to variant 1. Variant 3 encodes isoform 3 which is longer and lacks one of three LU (Ly-6 antigen/uPA receptor-like) domains, compared to isoform 2.
    Source sequence(s)
    CD370232, U08839
    Consensus CDS
    CCDS33042.1
    UniProtKB/Swiss-Prot
    Q03405
    Related
    ENSP00000221264.3, ENST00000221264.8
    Conserved Domains (2) summary
    smart00134
    Location:23 → 101
    LU; Ly-6 antigen / uPA receptor -like domain
    cd00117
    Location:170 → 251
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

  3. NM_001301037.2 → NP_001287966.1  urokinase plasminogen activator surface receptor isoform 4 precursor

    See identical proteins and their annotated locations for NP_001287966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 4, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AK290774, BY996586, CA495321, CF126152
    Consensus CDS
    CCDS74386.1
    UniProtKB/TrEMBL
    M0R1I2
    Related
    ENSP00000471881.1, ENST00000601723.5
    Conserved Domains (2) summary
    smart00134
    Location:115 → 202
    LU; Ly-6 antigen / uPA receptor -like domain
    pfam00021
    Location:25 → 99
    UPAR_LY6; u-PAR/Ly-6 domain

  4. NM_002659.4 → NP_002650.1  urokinase plasminogen activator surface receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_002650.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1) which contains three LU (Ly-6 antigen/uPA receptor-like) domains.
    Source sequence(s)
    BC002788, CD370232
    Consensus CDS
    CCDS12628.1
    UniProtKB/Swiss-Prot
    A8K409, Q03405, Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8, Q9UD69, Q9UEA6, Q9UM92, Q9UMV0
    Related
    ENSP00000339328.3, ENST00000340093.8
    Conserved Domains (3) summary
    smart00134
    Location:115 → 202
    LU; Ly-6 antigen / uPA receptor -like domain
    cd00117
    Location:215 → 296
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    cl10471
    Location:25 → 99
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43646095..43670169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438937.1 → XP_047294893.1  urokinase plasminogen activator surface receptor isoform X14

  2. XM_047438933.1 → XP_047294889.1  urokinase plasminogen activator surface receptor isoform X10

  3. XM_047438936.1 → XP_047294892.1  urokinase plasminogen activator surface receptor isoform X13

  4. XM_047438927.1 → XP_047294883.1  urokinase plasminogen activator surface receptor isoform X4

    Conserved Domains (2) summary
    smart00134
    Location:67 → 154
    LU; Ly-6 antigen / uPA receptor -like domain
    cd00117
    Location:167 → 248
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

  5. XM_047438934.1 → XP_047294890.1  urokinase plasminogen activator surface receptor isoform X11

  6. XM_047438935.1 → XP_047294891.1  urokinase plasminogen activator surface receptor isoform X12

  7. XM_047438926.1 → XP_047294882.1  urokinase plasminogen activator surface receptor isoform X3

  8. XM_047438928.1 → XP_047294884.1  urokinase plasminogen activator surface receptor isoform X5

    UniProtKB/TrEMBL
    M0R1I2
    Conserved Domains (2) summary
    smart00134
    Location:115 → 202
    LU; Ly-6 antigen / uPA receptor -like domain
    pfam00021
    Location:25 → 99
    UPAR_LY6; u-PAR/Ly-6 domain

  9. XM_047438925.1 → XP_047294881.1  urokinase plasminogen activator surface receptor isoform X1

    UniProtKB/Swiss-Prot
    A8K409, Q03405, Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8, Q9UD69, Q9UEA6, Q9UM92, Q9UMV0

  10. XM_047438929.1 → XP_047294885.1  urokinase plasminogen activator surface receptor isoform X6

  11. XM_047438930.1 → XP_047294886.1  urokinase plasminogen activator surface receptor isoform X7

  12. XM_047438931.1 → XP_047294887.1  urokinase plasminogen activator surface receptor isoform X8

  13. XM_017026872.3 → XP_016882361.1  urokinase plasminogen activator surface receptor isoform X2

  14. XM_047438932.1 → XP_047294888.1  urokinase plasminogen activator surface receptor isoform X9

    Related
    ENSP00000470029.1, ENST00000599892.5
    Conserved Domains (2) summary
    smart00134
    Location:115 → 203
    LU; Ly-6 antigen / uPA receptor -like domain
    pfam00021
    Location:25 → 99
    UPAR_LY6; u-PAR/Ly-6 domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46467757..46492325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321218.1 → XP_054177193.1  urokinase plasminogen activator surface receptor isoform X14

  2. XM_054321214.1 → XP_054177189.1  urokinase plasminogen activator surface receptor isoform X10

  3. XM_054321217.1 → XP_054177192.1  urokinase plasminogen activator surface receptor isoform X13

  4. XM_054321208.1 → XP_054177183.1  urokinase plasminogen activator surface receptor isoform X4

  5. XM_054321215.1 → XP_054177190.1  urokinase plasminogen activator surface receptor isoform X11

  6. XM_054321216.1 → XP_054177191.1  urokinase plasminogen activator surface receptor isoform X12

  7. XM_054321207.1 → XP_054177182.1  urokinase plasminogen activator surface receptor isoform X3

  8. XM_054321209.1 → XP_054177184.1  urokinase plasminogen activator surface receptor isoform X5

    UniProtKB/TrEMBL
    M0R1I2

  9. XM_054321205.1 → XP_054177180.1  urokinase plasminogen activator surface receptor isoform X1

    UniProtKB/Swiss-Prot
    A8K409, Q03405, Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8, Q9UD69, Q9UEA6, Q9UM92, Q9UMV0

  10. XM_054321206.1 → XP_054177181.1  urokinase plasminogen activator surface receptor isoform X2

  11. XM_054321210.1 → XP_054177185.1  urokinase plasminogen activator surface receptor isoform X6

  12. XM_054321211.1 → XP_054177186.1  urokinase plasminogen activator surface receptor isoform X7

  13. XM_054321212.1 → XP_054177187.1  urokinase plasminogen activator surface receptor isoform X8

  14. XM_054321213.1 → XP_054177188.1  urokinase plasminogen activator surface receptor isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03405.1 GenPept UniProtKB/Swiss-Prot:Q03405

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