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PLAUR plasminogen activator, urokinase receptor [ Homo sapiens (human) ]

Gene ID: 5329, updated on 18-Jun-2019

Summary

Official Symbol
PLAURprovided by HGNC
Official Full Name
plasminogen activator, urokinase receptorprovided by HGNC
Primary source
HGNC:HGNC:9053
See related
Ensembl:ENSG00000011422 MIM:173391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD87; UPAR; URKR; U-PAR
Summary
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 100.8), gall bladder (RPKM 18.1) and 5 other tissues See more
Orthologs

Genomic context

See PLAUR in Genome Data Viewer
Location:
19q13.31
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43646095..43670346, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44150247..44174498, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 428 Neighboring gene uncharacterized LOC105372411 Neighboring gene cell adhesion molecule 4 Neighboring gene uncharacterized LOC105372410 Neighboring gene RNA, 7SL, cytoplasmic 368, pseudogene Neighboring gene phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein-like Neighboring gene immunity related GTPase cinema

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of plasminogen activator, urokinase receptor (PLAUR) in human B cells PubMed
capsid gag A peptide (Ch7) derived from HIV-1 Capsid (amino acids 232-238) has been shown to have immunosuppressive effects through a possible interaction with the Plasminogen Receptor, indicating a role for Capsid in the immunosuppressive effects of HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Arf6 downstream pathway, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 downstream pathway, organism-specific biosystem
    Arf6 downstream pathway
  • Attachment of GPI anchor to uPAR, organism-specific biosystem (from REACTOME)
    Attachment of GPI anchor to uPAR, organism-specific biosystemThe mature form of urokinase plasminogen activator receptor (uPAR) is attached to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor (Ploug et al. 1991). As nascent uPAR polypeptide m...
  • Complement and Coagulation Cascades, organism-specific biosystem (from WikiPathways)
    Complement and Coagulation Cascades, organism-specific biosystemBlood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the for...
  • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
    Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement and coagulation cascades, conserved biosystem (from KEGG)
    Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Dissolution of Fibrin Clot, organism-specific biosystem (from REACTOME)
    Dissolution of Fibrin Clot, organism-specific biosystemThe crosslinked fibrin multimers in a clot are broken down to soluble polypeptides by plasmin, a serine protease. Plasmin can be generated from its inactive precursor plasminogen and recruited to the...
  • FGF signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    FGF signaling pathway, organism-specific biosystem
    FGF signaling pathway
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystem (from REACTOME)
    Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystemGlycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactio...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
    Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway Interaction Database)
    Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
    Validated transcriptional targets of AP1 family members Fra1 and Fra2
  • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
    amb2 Integrin signaling, organism-specific biosystem
    amb2 Integrin signaling

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
urokinase plasminogen activator receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of membrane TAS
Traceable Author Statement
more info
PubMed 
focal adhesion HDA PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
invadopodium membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
urokinase plasminogen activator surface receptor
Names
monocyte activation antigen Mo3
u-plasminogen activator receptor form 2
urokinase-type plasminogen activator (uPA) receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032898.1 RefSeqGene

    Range
    5001..26776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001005376.2NP_001005376.1  urokinase plasminogen activator surface receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001005376.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1. Variant 2 encodes the shortest isoform (2), also called suPLAUR, which is the soluble form of this protein. Isoform 2 lacks one of three LU (Ly-6 antigen/uPA receptor-like) domains, compared to isoform 1.
    Source sequence(s)
    AI801128, AI912302, CA495321, X74039
    Consensus CDS
    CCDS33041.1
    UniProtKB/Swiss-Prot
    Q03405
    Related
    ENSP00000342049.2, ENST00000339082.7
    Conserved Domains (2) summary
    smart00134
    Location:115202
    LU; Ly-6 antigen / uPA receptor -like domain
    cl10471
    Location:23101
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  2. NM_001005377.3NP_001005377.1  urokinase plasminogen activator surface receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001005377.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one exon in the coding region and encodes an isoleucine rather than a valine following the splice site, compared to variant 1. Variant 3 encodes isoform 3 which is longer and lacks one of three LU (Ly-6 antigen/uPA receptor-like) domains, compared to isoform 2.
    Source sequence(s)
    CD370232, U08839
    Consensus CDS
    CCDS33042.1
    UniProtKB/Swiss-Prot
    Q03405
    Related
    ENSP00000221264.3, ENST00000221264.8
    Conserved Domains (2) summary
    smart00134
    Location:23101
    LU; Ly-6 antigen / uPA receptor -like domain
    cd00117
    Location:170251
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  3. NM_001301037.2NP_001287966.1  urokinase plasminogen activator surface receptor isoform 4 precursor

    See identical proteins and their annotated locations for NP_001287966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 4, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AK290774, BY996586, CA495321, CF126152
    Consensus CDS
    CCDS74386.1
    UniProtKB/Swiss-Prot
    Q03405
    UniProtKB/TrEMBL
    M0R1I2
    Related
    ENSP00000471881.1, ENST00000601723.5
    Conserved Domains (1) summary
    smart00134
    Location:115202
    LU; Ly-6 antigen / uPA receptor -like domain
  4. NM_002659.4NP_002650.1  urokinase plasminogen activator surface receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_002650.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1) which contains three LU (Ly-6 antigen/uPA receptor-like) domains.
    Source sequence(s)
    BC002788, CD370232
    Consensus CDS
    CCDS12628.1
    UniProtKB/Swiss-Prot
    Q03405
    Related
    ENSP00000339328.3, ENST00000340093.8
    Conserved Domains (3) summary
    smart00134
    Location:115202
    LU; Ly-6 antigen / uPA receptor -like domain
    cd00117
    Location:215296
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    cl10471
    Location:2599
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43646095..43670346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527029.2XP_011525331.1  urokinase plasminogen activator surface receptor isoform X4

    See identical proteins and their annotated locations for XP_011525331.1

    Related
    ENSP00000470029.1, ENST00000599892.5
    Conserved Domains (1) summary
    smart00134
    Location:115203
    LU; Ly-6 antigen / uPA receptor -like domain
  2. XM_011527031.3XP_011525333.1  urokinase plasminogen activator surface receptor isoform X6

    See identical proteins and their annotated locations for XP_011525333.1

    Conserved Domains (2) summary
    smart00134
    Location:115203
    LU; Ly-6 antigen / uPA receptor -like domain
    cl10471
    Location:23101
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  3. XM_011527030.2XP_011525332.1  urokinase plasminogen activator surface receptor isoform X5

    Conserved Domains (1) summary
    smart00134
    Location:115202
    LU; Ly-6 antigen / uPA receptor -like domain
  4. XM_011527028.3XP_011525330.1  urokinase plasminogen activator surface receptor isoform X4

    See identical proteins and their annotated locations for XP_011525330.1

    Conserved Domains (1) summary
    smart00134
    Location:115203
    LU; Ly-6 antigen / uPA receptor -like domain
  5. XM_011527027.2XP_011525329.1  urokinase plasminogen activator surface receptor isoform X2

    See identical proteins and their annotated locations for XP_011525329.1

    Conserved Domains (2) summary
    smart00134
    Location:67154
    LU; Ly-6 antigen / uPA receptor -like domain
    cd00117
    Location:167248
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  6. XM_017026872.2XP_016882361.1  urokinase plasminogen activator surface receptor isoform X1

  7. XM_017026873.1XP_016882362.1  urokinase plasminogen activator surface receptor isoform X7

  8. XM_005258990.5XP_005259047.1  urokinase plasminogen activator surface receptor isoform X3

    See identical proteins and their annotated locations for XP_005259047.1

    Conserved Domains (3) summary
    smart00134
    Location:115202
    LU; Ly-6 antigen / uPA receptor -like domain
    cd00117
    Location:215269
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    cl10471
    Location:23101
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
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