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PLA2G5 phospholipase A2 group V [ Homo sapiens (human) ]

Gene ID: 5322, updated on 1-Jun-2020

Summary

Official Symbol
PLA2G5provided by HGNC
Official Full Name
phospholipase A2 group Vprovided by HGNC
Primary source
HGNC:HGNC:9038
See related
Ensembl:ENSG00000127472 MIM:601192
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRFB; GV-PLA2; PLA2-10; hVPLA(2)
Summary
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 14.5), ovary (RPKM 8.6) and 8 other tissues See more
Orthologs

Genomic context

See PLA2G5 in Genome Data Viewer
Location:
1p36.13
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (20028349..20091911)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20386157..20418394)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 304, pseudogene Neighboring gene phospholipase A2 group IIA Neighboring gene prenylcysteine oxidase 1 pseudogene Neighboring gene phospholipase A2 group IID Neighboring gene phospholipase A2 group IIF

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC46205, DKFZp686C2294

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cardiolipin acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
leukotriene biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
phagosome-lysosome fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylcholine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylinositol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet activating factor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of antifungal innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of immune complex clearance by monocytes and macrophages IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macrophage derived foam cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of opsonization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phagosome maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to cytokine IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
early phagosome ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
phagolysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium-dependent phospholipase A2
Names
Ca2+-dependent phospholipase A2
phosphatidylcholine 2-acylhydrolase 5
NP_000920.1
XP_005245948.1
XP_005245949.1
XP_005245950.1
XP_011539888.1
XP_011539889.1
XP_011539890.1
XP_011539891.1
XP_011539892.1
XP_011539893.1
XP_011539894.1
XP_024303474.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032045.1 RefSeqGene

    Range
    4987..26704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000929.3NP_000920.1  calcium-dependent phospholipase A2 precursor

    See identical proteins and their annotated locations for NP_000920.1

    Status: REVIEWED

    Source sequence(s)
    AL158172, AV709457, BC036792, BM684907, BM705479
    Consensus CDS
    CCDS202.1
    UniProtKB/Swiss-Prot
    P39877
    Related
    ENSP00000364249.3, ENST00000375108.4
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    20028349..20091911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541589.3XP_011539891.1  calcium-dependent phospholipase A2 isoform X2

    See identical proteins and their annotated locations for XP_011539891.1

    UniProtKB/Swiss-Prot
    P39877
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  2. XM_011541588.3XP_011539890.1  calcium-dependent phospholipase A2 isoform X2

    See identical proteins and their annotated locations for XP_011539890.1

    UniProtKB/Swiss-Prot
    P39877
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  3. XM_011541590.3XP_011539892.1  calcium-dependent phospholipase A2 isoform X2

    See identical proteins and their annotated locations for XP_011539892.1

    UniProtKB/Swiss-Prot
    P39877
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  4. XM_011541592.3XP_011539894.1  calcium-dependent phospholipase A2 isoform X2

    See identical proteins and their annotated locations for XP_011539894.1

    UniProtKB/Swiss-Prot
    P39877
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  5. XM_005245891.5XP_005245948.1  calcium-dependent phospholipase A2 isoform X1

    See identical proteins and their annotated locations for XP_005245948.1

    Conserved Domains (1) summary
    cd00125
    Location:52168
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  6. XM_011541587.3XP_011539889.1  calcium-dependent phospholipase A2 isoform X2

    See identical proteins and their annotated locations for XP_011539889.1

    UniProtKB/Swiss-Prot
    P39877
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  7. XM_005245892.5XP_005245949.1  calcium-dependent phospholipase A2 isoform X1

    See identical proteins and their annotated locations for XP_005245949.1

    Related
    ENST00000465698.5
    Conserved Domains (1) summary
    cd00125
    Location:52168
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  8. XM_011541591.3XP_011539893.1  calcium-dependent phospholipase A2 isoform X2

    See identical proteins and their annotated locations for XP_011539893.1

    UniProtKB/Swiss-Prot
    P39877
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  9. XM_011541586.3XP_011539888.1  calcium-dependent phospholipase A2 isoform X1

    See identical proteins and their annotated locations for XP_011539888.1

    Conserved Domains (1) summary
    cd00125
    Location:52168
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  10. XM_005245893.5XP_005245950.1  calcium-dependent phospholipase A2 isoform X2

    See identical proteins and their annotated locations for XP_005245950.1

    UniProtKB/Swiss-Prot
    P39877
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  11. XM_024447706.1XP_024303474.1  calcium-dependent phospholipase A2 isoform X3

    Conserved Domains (1) summary
    cl05417
    Location:2162
    PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
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