Format

Send to:

Choose Destination

PIP prolactin induced protein [ Homo sapiens (human) ]

Gene ID: 5304, updated on 3-Jun-2018
Official Symbol
PIPprovided by HGNC
Official Full Name
prolactin induced proteinprovided by HGNC
Primary source
HGNC:HGNC:8993
See related
Ensembl:ENSG00000159763 MIM:176720; Vega:OTTHUMG00000152635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPIP4; GCDFP15; GCDFP-15
Expression
Restricted expression toward salivary gland (RPKM 2757.7) See more
Orthologs
See PIP in Genome Data Viewer
Location:
7q34
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (143132081..143139741)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (142829174..142836834)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily V member 1 Neighboring gene olfactory receptor family 6 subfamily W member 1 pseudogene Neighboring gene taste 2 receptor member 39 Neighboring gene taste 2 receptor member 40

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Gross cystic disease fluid protein-15 (GCDFP-15) binds to CD4, a T-cell co-receptor involved in antigen recognition, thereby inhibiting the ability of the receptor to interact with the HIV-1 envelope protein gp120 PubMed
env Binding of HIV-1 envelope protein gp120 to CD4 downregulates Bcl-2 expression; this effect is inhibited by gp17/GCDFP-15, which blocks the ability of CD4 to interact with gp120, leading to moderate up-regulation of Bcl-2 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgG binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding NAS
Non-traceable Author Statement
more info
PubMed 
aspartic-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
prolactin-inducible protein
Names
SABP
gross cystic disease fluid protein 15
secretory actin-binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002652.2NP_002643.1  prolactin-inducible protein precursor

    See identical proteins and their annotated locations for NP_002643.1

    Status: VALIDATED

    Source sequence(s)
    CD723133, Y10179
    Consensus CDS
    CCDS34768.1
    UniProtKB/Swiss-Prot
    P12273
    Related
    ENSP00000291009.3, OTTHUMP00000202101, ENST00000291009.3, OTTHUMT00000327089
    Conserved Domains (1) summary
    pfam05326
    Location:4126
    SVA; Seminal vesicle autoantigen (SVA)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    143132081..143139741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center