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Txndc17 thioredoxin domain containing 17 [ Mus musculus (house mouse) ]

Gene ID: 52700, updated on 11-Apr-2024


Official Symbol
Txndc17provided by MGI
Official Full Name
thioredoxin domain containing 17provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000020803 AllianceGenome:MGI:1289248
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRP14; Txnl5; D11Ertd672e; 4831443O22Rik
Predicted to enable peroxidase activity and protein-disulfide reductase (NAD(P)) activity. Predicted to be involved in tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human TXNDC17 (thioredoxin domain containing 17). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in placenta adult (RPKM 53.8), large intestine adult (RPKM 37.7) and 28 other tissues See more
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Genomic context

See Txndc17 in Genome Data Viewer
11 B4; 11 43.92 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72098380..72101313)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72207554..72210487)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene PITPNM family member 3 Neighboring gene predicted gene, 46286 Neighboring gene STARR-seq mESC enhancer starr_29899 Neighboring gene RIKEN cDNA 4933427D14 gene Neighboring gene RIKEN cDNA 4930563E22 gene Neighboring gene STARR-positive B cell enhancer ABC_E3970 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72029072-72029181 Neighboring gene predicted gene, 57849 Neighboring gene mediator complex subunit 31 Neighboring gene solute carrier family 13 (sodium-dependent citrate transporter), member 5 Neighboring gene predicted gene, 34252

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a




Alleles of this type are documented at Mouse Genome Informatics  (MGI)


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peroxidase activity ISO
Inferred from Sequence Orthology
more info
enables protein-disulfide reductase (NAD(P)H) activity IBA
Inferred from Biological aspect of Ancestor
more info
enables protein-disulfide reductase (NAD(P)H) activity ISO
Inferred from Sequence Orthology
more info
Process Evidence Code Pubs
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
located_in cytosol ISO
Inferred from Sequence Orthology
more info

General protein information

Preferred Names
thioredoxin domain-containing protein 17
14 kDa thioredoxin-related protein
protein 42-9-9
putative 42-9-9 protein
thioredoxin-like 5
thioredoxin-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026559.3NP_080835.1  thioredoxin domain-containing protein 17

    See identical proteins and their annotated locations for NP_080835.1

    Status: VALIDATED

    Source sequence(s)
    Consensus CDS
    Q3TE14, Q921A9, Q9CQM5, Q9D0Y4
    ENSMUSP00000021158.4, ENSMUST00000021158.4
    Conserved Domains (1) summary
    TRP14_like; Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a 14kD cytosolic protein that shows disulfide reductase activity in vitro with a different substrate specificity compared with another human cytosolic protein, TRX1. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000077.7 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)