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TXNDC17 thioredoxin domain containing 17 [ Homo sapiens (human) ]

Gene ID: 84817, updated on 6-Sep-2022

Summary

Official Symbol
TXNDC17provided by HGNC
Official Full Name
thioredoxin domain containing 17provided by HGNC
Primary source
HGNC:HGNC:28218
See related
Ensembl:ENSG00000129235 MIM:616967; AllianceGenome:HGNC:28218
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRP14; TXNL5
Summary
Enables peroxidase activity and protein-disulfide reductase (NAD(P)) activity. Involved in tumor necrosis factor-mediated signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 14.3), esophagus (RPKM 13.2) and 25 other tissues See more
Orthologs
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Genomic context

See TXNDC17 in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (6641060..6644541)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (6541691..6545172)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6544380..6547861)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene KIAA0753 Neighboring gene RNA, 5S ribosomal pseudogene 435 Neighboring gene uncharacterized LOC122526780 Neighboring gene mediator complex subunit 31 Neighboring gene chromosome 17 open reading frame 100 Neighboring gene microRNA 4520-1 Neighboring gene microRNA 4520-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14353

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-disulfide reductase (NAD(P)) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-disulfide reductase (NAD(P)) activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
thioredoxin domain-containing protein 17
Names
14 kDa thioredoxin-related protein
protein 42-9-9
testicular tissue protein Li 214
thioredoxin (Trx)-related protein, 14 kDa
thioredoxin-like 5
thioredoxin-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032731.4NP_116120.1  thioredoxin domain-containing protein 17

    See identical proteins and their annotated locations for NP_116120.1

    Status: VALIDATED

    Source sequence(s)
    AC004706, BC006405
    Consensus CDS
    CCDS11077.1
    UniProtKB/Swiss-Prot
    A8K7E8, Q9BRA2
    UniProtKB/TrEMBL
    A0A140VJY7
    Related
    ENSP00000250101.5, ENST00000250101.10
    Conserved Domains (1) summary
    cd02952
    Location:4121
    TRP14_like; Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a 14kD cytosolic protein that shows disulfide reductase activity in vitro with a different substrate specificity compared with another human cytosolic protein, TRX1. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    6641060..6644541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    6541691..6545172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)