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PGK2 phosphoglycerate kinase 2 [ Homo sapiens (human) ]

Gene ID: 5232, updated on 17-Jun-2019

Summary

Official Symbol
PGK2provided by HGNC
Official Full Name
phosphoglycerate kinase 2provided by HGNC
Primary source
HGNC:HGNC:8898
See related
Ensembl:ENSG00000170950 MIM:172270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGKB; PGKPS; HEL-S-272; dJ417L20.2
Summary
This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]
Orthologs

Genomic context

See PGK2 in Genome Data Viewer
Location:
6p12.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (49785660..49787285, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49753364..49755053, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene cysteine rich secretory protein 2 Neighboring gene cysteine rich secretory protein 3 Neighboring gene uncharacterized LOC101927020 Neighboring gene uncharacterized LOC101927048 Neighboring gene cysteine rich secretory protein 1

Genomic regions, transcripts, and products

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of phosphoglycerate kinase 2 (PGK2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphoglycerate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphoglycerate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphoglycerate kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolytic process IEA
Inferred from Electronic Annotation
more info
 
glycolytic process NAS
Non-traceable Author Statement
more info
PubMed 
phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of oxidative phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
nucleus HDA PubMed 
sperm fibrous sheath IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphoglycerate kinase 2
Names
epididymis secretory protein Li 272
phosphoglycerate kinase autosomal pseudogene
phosphoglycerate kinase, testis specific
testicular tissue protein Li 139
NP_620061.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138733.5NP_620061.2  phosphoglycerate kinase 2

    See identical proteins and their annotated locations for NP_620061.2

    Status: REVIEWED

    Source sequence(s)
    BC038843
    Consensus CDS
    CCDS4930.1
    UniProtKB/Swiss-Prot
    P07205
    UniProtKB/TrEMBL
    A0A140VJR3
    Related
    ENSP00000305995.3, ENST00000304801.5
    Conserved Domains (1) summary
    PTZ00005
    Location:3416
    PTZ00005; phosphoglycerate kinase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    49785660..49787285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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