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PGK2 phosphoglycerate kinase 2 [ Homo sapiens (human) ]

Gene ID: 5232, updated on 27-Nov-2024

Summary

Official Symbol
PGK2provided by HGNC
Official Full Name
phosphoglycerate kinase 2provided by HGNC
Primary source
HGNC:HGNC:8898
See related
Ensembl:ENSG00000170950 MIM:172270; AllianceGenome:HGNC:8898
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGKB; PGKPS; HEL-S-272; dJ417L20.2
Summary
This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]
Orthologs
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Genomic context

See PGK2 in Genome Data Viewer
Location:
6p12.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (49785660..49787285, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (49627627..49629252, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49753373..49754998, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene cysteine rich secretory protein 2 Neighboring gene MPRA-validated peak5838 silencer Neighboring gene MPRA-validated peak5839 silencer Neighboring gene cysteine rich secretory protein 3 Neighboring gene uncharacterized LOC101927020 Neighboring gene uncharacterized LOC101927048 Neighboring gene cysteine rich secretory protein 1

Genomic regions, transcripts, and products

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of phosphoglycerate kinase 2 (PGK2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphoglycerate kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables phosphoglycerate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphoglycerate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphoglycerate kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in canonical glycolysis TAS
Traceable Author Statement
more info
 
involved_in flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gluconeogenesis TAS
Traceable Author Statement
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycolytic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in sperm fibrous sheath IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
phosphoglycerate kinase 2
Names
epididymis secretory protein Li 272
phosphoglycerate kinase autosomal pseudogene
phosphoglycerate kinase, testis specific
testicular tissue protein Li 139
NP_620061.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138733.5NP_620061.2  phosphoglycerate kinase 2

    See identical proteins and their annotated locations for NP_620061.2

    Status: REVIEWED

    Source sequence(s)
    BC038843
    Consensus CDS
    CCDS4930.1
    UniProtKB/Swiss-Prot
    B2R6Y8, P07205, Q9H107
    UniProtKB/TrEMBL
    A0A140VJR3, V9HW85
    Related
    ENSP00000305995.3, ENST00000304801.6
    Conserved Domains (1) summary
    PTZ00005
    Location:3416
    PTZ00005; phosphoglycerate kinase; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    49785660..49787285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    49627627..49629252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)