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PGC progastricsin [ Homo sapiens (human) ]

Gene ID: 5225, updated on 3-Jun-2018
Official Symbol
PGCprovided by HGNC
Official Full Name
progastricsinprovided by HGNC
Primary source
HGNC:HGNC:8890
See related
Ensembl:ENSG00000096088 MIM:169740; Vega:OTTHUMG00000014683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEPC; PGII
Summary
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
Expression
Restricted expression toward stomach (RPKM 7385.5) See more
Orthologs
See PGC in Genome Data Viewer
Location:
6p21.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (41736711..41747401, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41704449..41715139, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene nucleophosmin 1 pseudogene 51 Neighboring gene transcription factor EB Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene prickle planar cell polarity protein 4

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ99563

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aspartic-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
digestion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of antibacterial peptide production IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
gastricsin
Names
pepsin C
pepsinogen C
pepsinogen group II
preprogastricsin
NP_001159896.1
NP_002621.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166424.1NP_001159896.1  gastricsin isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001159896.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK301298, AL365205
    Consensus CDS
    CCDS55000.1
    UniProtKB/Swiss-Prot
    P20142
    Related
    ENSP00000405094.2, ENST00000425343.6
    Conserved Domains (2) summary
    pfam07966
    Location:1846
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:70216
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
  2. NM_002630.3NP_002621.1  gastricsin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_002621.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL365205, BC073740
    Consensus CDS
    CCDS4859.1
    UniProtKB/Swiss-Prot
    P20142
    Related
    ENSP00000362116.3, OTTHUMP00000016377, ENST00000373025.7, OTTHUMT00000040521
    Conserved Domains (3) summary
    cd05477
    Location:70387
    gastricsin; Gastricsins, asparate proteases produced in gastric mucosa
    pfam00026
    Location:72387
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:1846
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    41736711..41747401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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