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PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [ Homo sapiens (human) ]

Gene ID: 5208, updated on 2-Mar-2021

Summary

Official Symbol
PFKFB2provided by HGNC
Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2provided by HGNC
Primary source
HGNC:HGNC:8873
See related
Ensembl:ENSG00000123836 MIM:171835
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PFK-2/FBPase-2
Summary
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 25.6), duodenum (RPKM 11.7) and 19 other tissues See more
Orthologs
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Genomic context

See PFKFB2 in Genome Data Viewer
Location:
1q32.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (207053063..207081027)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207226620..207254372)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 116 Neighboring gene uncharacterized LOC107984109 Neighboring gene YOD1 deubiquitinase Neighboring gene complement component 4 binding protein beta Neighboring gene complement component 4 binding protein alpha Neighboring gene uncharacterized LOC107985251

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138308, MGC138310, DKFZp781D2217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
6-phosphofructo-2-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
6-phosphofructo-2-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
fructose-2,6-bisphosphate 2-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
fructose 2,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose catabolic process IEA
Inferred from Electronic Annotation
more info
 
glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
lactate metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glucokinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glycolytic process TAS
Traceable Author Statement
more info
 
positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Names
6PF-2-K/Fru-2,6-P2ASE heart-type isozyme
6PF-2-K/Fru-2,6-P2ase 2
PFK/FBPase 2
PFKFB, cardiac
fructose-2,6-bisphosphatase, cardiac isozyme
NP_001018063.1
NP_006203.2
XP_005273219.1
XP_024303422.1
XP_024303423.1
XP_024303424.1
XP_024303425.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018053.2NP_001018063.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform b

    See identical proteins and their annotated locations for NP_001018063.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AF470623, AL445493, BX510096
    Consensus CDS
    CCDS31003.1
    UniProtKB/Swiss-Prot
    O60825
    Related
    ENSP00000356046.2, ENST00000367079.3
    Conserved Domains (2) summary
    pfam00300
    Location:252435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26249
    6PF2K; 6-phosphofructo-2-kinase
  2. NM_006212.2NP_006203.2  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform a

    See identical proteins and their annotated locations for NP_006203.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL445493, BC069583, BX510096
    Consensus CDS
    CCDS31004.1
    UniProtKB/Swiss-Prot
    O60825
    Related
    ENSP00000356047.3, ENST00000367080.8
    Conserved Domains (2) summary
    pfam00300
    Location:252435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26249
    6PF2K; 6-phosphofructo-2-kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    207053063..207081027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447657.1XP_024303425.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X3

    Conserved Domains (2) summary
    pfam00300
    Location:252435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26249
    6PF2K; 6-phosphofructo-2-kinase
  2. XM_024447654.1XP_024303422.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X1

    Conserved Domains (2) summary
    pfam00300
    Location:252435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26249
    6PF2K; 6-phosphofructo-2-kinase
  3. XM_024447655.1XP_024303423.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X1

    Conserved Domains (2) summary
    pfam00300
    Location:252435
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26249
    6PF2K; 6-phosphofructo-2-kinase
  4. XM_024447656.1XP_024303424.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X2

    Conserved Domains (2) summary
    pfam01591
    Location:1216
    6PF2K; 6-phosphofructo-2-kinase
    pfam00300
    Location:219402
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
  5. XM_005273162.3XP_005273219.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X4

    Conserved Domains (1) summary
    pfam00300
    Location:10193
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
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