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Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [ Mus musculus (house mouse) ]

Gene ID: 18640, updated on 5-Jan-2023

Summary

Official Symbol
Pfkfb2provided by MGI
Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2provided by MGI
Primary source
MGI:MGI:107815
See related
Ensembl:ENSMUSG00000026409 AllianceGenome:MGI:107815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930568D07Rik
Summary
Enables fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in several processes, including fructose 2,6-bisphosphate metabolic process; monocarboxylic acid metabolic process; and positive regulation of glucokinase activity. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 6.3), frontal lobe adult (RPKM 5.3) and 28 other tissues See more
Orthologs
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Genomic context

See Pfkfb2 in Genome Data Viewer
Location:
1; 1 E4
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130616780..130656990, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130689043..130729253, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene complement component 4 binding protein Neighboring gene complement component 4 binding protein, pseudogene 1 Neighboring gene YOD1 deubiquitinase Neighboring gene expressed sequence AA986860 Neighboring gene predicted gene 28857 Neighboring gene predicted gene 28856

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 6-phosphofructo-2-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 6-phosphofructo-2-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 6-phosphofructo-2-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fructose-2,6-bisphosphate 2-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fructose-2,6-bisphosphate 2-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fructose 2,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lactate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in pyruvate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Names
6PF-2-K/Fru-2,6-P2ase 2
6PF-2-K/Fru-2,6-P2ase heart-type isozyme
PFK-2/FBPase-2 gene B
PFK/FBPase 2
NP_001155887.1
NP_001155888.1
NP_001355772.1
NP_032851.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162415.1NP_001155887.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 2

    See identical proteins and their annotated locations for NP_001155887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC139231, AK029659, BC051014
    Consensus CDS
    CCDS48350.1
    UniProtKB/TrEMBL
    B2Z893, Q6GTL7, Q8CDS6
    Related
    ENSMUSP00000140355.2, ENSMUST00000189534.7
    Conserved Domains (3) summary
    pfam00300
    Location:254437
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:30251
    6PF2K; 6-phosphofructo-2-kinase
    pfam13671
    Location:42197
    AAA_33; AAA domain
  2. NM_001162416.1NP_001155888.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 3

    See identical proteins and their annotated locations for NP_001155888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, and the 5' and 3' splice patterns have not been determined. The resulting isoform (3) lacks an internal segment near the C-terminus, compared to isoform 1.
    Source sequence(s)
    BC051014, EU616667
    Consensus CDS
    CCDS48349.1
    UniProtKB/TrEMBL
    B2Z892, Q6GTL7
    Related
    ENSMUSP00000133073.3, ENSMUST00000050406.11
    Conserved Domains (3) summary
    pfam00300
    Location:254406
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:30251
    6PF2K; 6-phosphofructo-2-kinase
    pfam13671
    Location:42197
    AAA_33; AAA domain
  3. NM_001368843.1NP_001355772.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC139231
    Consensus CDS
    CCDS87871.1
    UniProtKB/TrEMBL
    A0A087WRG0
    Related
    ENSMUSP00000140612.2, ENSMUST00000187089.7
    Conserved Domains (2) summary
    pfam00300
    Location:254437
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:31251
    6PF2K; 6-phosphofructo-2-kinase
  4. NM_008825.4NP_032851.2  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 1

    See identical proteins and their annotated locations for NP_032851.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and isoform 1.
    Source sequence(s)
    AC139231
    Consensus CDS
    CCDS35701.1
    UniProtKB/Swiss-Prot
    P70265
    UniProtKB/TrEMBL
    Q6GTL7
    Related
    ENSMUSP00000127587.3, ENSMUST00000169659.8
    Conserved Domains (3) summary
    pfam00300
    Location:254437
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:30251
    6PF2K; 6-phosphofructo-2-kinase
    pfam13671
    Location:42197
    AAA_33; AAA domain

RNA

  1. NR_027859.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a distinct 3' splice pattern, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC139231, BC051014

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130616780..130656990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)