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PFDN5 prefoldin subunit 5 [ Homo sapiens (human) ]

Gene ID: 5204, updated on 7-Jun-2020

Summary

Official Symbol
PFDN5provided by HGNC
Official Full Name
prefoldin subunit 5provided by HGNC
Primary source
HGNC:HGNC:8869
See related
Ensembl:ENSG00000123349 MIM:604899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MM1; MM-1; PFD5
Summary
This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 223.5), thyroid (RPKM 192.0) and 25 other tissues See more
Orthologs

Genomic context

See PFDN5 in Genome Data Viewer
Location:
12q13.13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (53295451..53299450)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53689235..53693234)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 5 Neighboring gene extra spindle pole bodies like 1, separase Neighboring gene Sharpr-MPRA regulatory region 12 Neighboring gene MYG1 antisense RNA 1 Neighboring gene MYG1 exonuclease Neighboring gene aladin WD repeat nucleoporin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5329, MGC71907

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein folding IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
prefoldin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
prefoldin subunit 5
Names
c-myc binding protein
myc modulator-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029695.1 RefSeqGene

    Range
    5092..9000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002624.4NP_002615.2  prefoldin subunit 5 isoform alpha

    See identical proteins and their annotated locations for NP_002615.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (alpha).
    Source sequence(s)
    AB055803, AB055805
    Consensus CDS
    CCDS8853.1
    UniProtKB/Swiss-Prot
    Q99471
    Related
    ENSP00000334188.4, ENST00000334478.9
    Conserved Domains (1) summary
    TIGR00293
    Location:12138
    TIGR00293; prefoldin, archaeal alpha subunit/eukaryotic subunit 5
  2. NM_145897.2NP_665904.1  prefoldin subunit 5 isoform gamma

    See identical proteins and their annotated locations for NP_665904.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons in the coding region but maintains the reading frame, compared to variant 1. The encoded protein (isoform gamma) is shorter than isoform alpha.
    Source sequence(s)
    AB055805, BE392248
    Consensus CDS
    CCDS8854.1
    UniProtKB/Swiss-Prot
    Q99471
    Related
    ENSP00000266964.4, ENST00000351500.7
    Conserved Domains (1) summary
    cl09111
    Location:2493
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    53295451..53299450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145896.2: Suppressed sequence

    Description
    NM_145896.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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