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Pfdn5 prefoldin 5 [ Mus musculus (house mouse) ]

Gene ID: 56612, updated on 8-Jan-2023

Summary

Official Symbol
Pfdn5provided by MGI
Official Full Name
prefoldin 5provided by MGI
Primary source
MGI:MGI:1928753
See related
Ensembl:ENSMUSG00000001289 AllianceGenome:MGI:1928753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eig1; MM-1; D15Ertd697e; 1190001O17Rik; 1700010A06Rik
Summary
Predicted to enable amyloid-beta binding activity and unfolded protein binding activity. Acts upstream of or within retina development in camera-type eye. Predicted to be located in cytosol and intermediate filament cytoskeleton. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Is expressed in brain; genitourinary system; gut gland; and trachea. Orthologous to human PFDN5 (prefoldin subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 164.4), testis adult (RPKM 156.9) and 27 other tissues See more
Orthologs
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Genomic context

See Pfdn5 in Genome Data Viewer
Location:
15 F2; 15 57.48 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102234551..102239925)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102326116..102331490)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 5 Neighboring gene extra spindle pole bodies 1, separase Neighboring gene microRNA 12187 Neighboring gene melanocyte proliferating gene 1 Neighboring gene achalasia, adrenocortical insufficiency, alacrimia

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of prefoldin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of prefoldin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
prefoldin subunit 5
Names
C-myc-binding protein Mm-1
EIG-1
c-myc binding protein MM-1
myc modulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027044.3NP_081320.2  prefoldin subunit 5

    See identical proteins and their annotated locations for NP_081320.2

    Status: VALIDATED

    Source sequence(s)
    AF108357, CN835522
    Consensus CDS
    CCDS37227.1
    UniProtKB/Swiss-Prot
    Q9JMJ8, Q9WU28
    UniProtKB/TrEMBL
    A0A8C6I4B7
    Related
    ENSMUSP00000129178.2, ENSMUST00000166658.8
    Conserved Domains (1) summary
    TIGR00293
    Location:12138
    TIGR00293; prefoldin, archaeal alpha subunit/eukaryotic subunit 5

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102234551..102239925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020031.1: Suppressed sequence

    Description
    NM_020031.1: This RefSeq was permanently suppressed because it was based on a chimeric source sequence (AB011473.1), and the N-terminus of the encoded protein is not supported.