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GATB glutamyl-tRNA amidotransferase subunit B [ Homo sapiens (human) ]

Gene ID: 5188, updated on 25-Nov-2021

Summary

Official Symbol
GATBprovided by HGNC
Official Full Name
glutamyl-tRNA amidotransferase subunit Bprovided by HGNC
Primary source
HGNC:HGNC:8849
See related
Ensembl:ENSG00000059691 MIM:603645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PET112; COXPD41; HSPC199; PET112L
Expression
Ubiquitous expression in heart (RPKM 11.7), kidney (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

See GATB in Genome Data Viewer
Location:
4q31.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (151670504..151761007, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (152591656..152682159, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene FHIP1A divergent transcript Neighboring gene FHF complex subunit HOOK interacting protein 1A Neighboring gene RN7SK pseudogene 35 Neighboring gene uncharacterized LOC107986197 Neighboring gene uncharacterized LOC105377488 Neighboring gene uncharacterized LOC102724700 Neighboring gene uncharacterized LOC100505685

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of glutamyl-tRNA(Gln) amidotransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of glutamyl-tRNA(Gln) amidotransferase complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
Names
PET112 homolog
cytochrome c oxidase assembly factor PET112 homolog
cytochrome oxidase assembly factor PET112 homolog
glutamyl-tRNA(Gln) amidotransferase, subunit B
NP_001350270.1
NP_004555.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363341.2NP_001350270.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, comapred to variant 1, and encodes a shorter isoform (2) , compared to isoform 1
    Source sequence(s)
    AC092611
    Conserved Domains (1) summary
    PRK05477
    Location:62510
    gatB; aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated
  2. NM_004564.3NP_004555.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_004555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC092611, BC130348
    Consensus CDS
    CCDS3776.1
    UniProtKB/Swiss-Prot
    O75879
    Related
    ENSP00000263985.6, ENST00000263985.11
    Conserved Domains (3) summary
    PRK05477
    Location:62555
    gatB; aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated
    pfam02637
    Location:406555
    GatB_Yqey; GatB domain
    pfam02934
    Location:65348
    GatB_N; GatB/GatE catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    151670504..151761007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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