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Gatb glutamyl-tRNA(Gln) amidotransferase, subunit B [ Mus musculus (house mouse) ]

Gene ID: 229487, updated on 8-Dec-2022

Summary

Official Symbol
Gatbprovided by MGI
Official Full Name
glutamyl-tRNA(Gln) amidotransferase, subunit Bprovided by MGI
Primary source
MGI:MGI:2442496
See related
Ensembl:ENSMUSG00000028085 AllianceGenome:MGI:2442496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pet112; Pet112l; 9430026F02Rik
Summary
Predicted to enable glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Predicted to be involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 41. Orthologous to human GATB (glutamyl-tRNA amidotransferase subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 8.6), heart adult (RPKM 5.7) and 28 other tissues See more
Orthologs
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Genomic context

See Gatb in Genome Data Viewer
Location:
3; 3 F1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (85481409..85562931)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (85574102..85655624)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31419 Neighboring gene microRNA 466k Neighboring gene predicted gene 3740 Neighboring gene predicted gene, 54168 Neighboring gene predicted gene, 46809 Neighboring gene FHF complex subunit HOOK interacting protein 1A Neighboring gene predicted gene, 40082 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11629

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutaminyl-tRNAGln biosynthesis via transamidation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial translation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of glutamyl-tRNA(Gln) amidotransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
Names
PET112 homolog
cytochrome c oxidase assembly factor PET112 homolog
cytochrome oxidase assembly factor PET112 homolog
glu-AdT subunit B
probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
NP_659145.1
XP_006501392.1
XP_006501393.1
XP_006501394.1
XP_011238382.1
XP_036018934.1
XP_036018935.1
XP_036018936.1
XP_036018937.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399230.1NP_001386159.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102296, AC102338
    UniProtKB/TrEMBL
    Q8BW84
    Conserved Domains (1) summary
    PRK05477
    Location:62516
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB
  2. NM_144896.5NP_659145.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_659145.1

    Status: VALIDATED

    Source sequence(s)
    AC102296, AC102338
    Consensus CDS
    CCDS17441.1
    UniProtKB/Swiss-Prot
    Q8BUY3, Q99JT1
    UniProtKB/TrEMBL
    A0A8C6HNC6
    Related
    ENSMUSP00000119949.2, ENSMUST00000127348.8
    Conserved Domains (3) summary
    PRK05477
    Location:62555
    gatB; aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated
    pfam02637
    Location:406555
    GatB_Yqey; GatB domain
    pfam02934
    Location:65351
    GatB_N; GatB/GatE catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    85481409..85562931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501329.3XP_006501392.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X1

    Conserved Domains (1) summary
    PRK05477
    Location:62580
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB
  2. XM_006501330.2XP_006501393.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X2

    Conserved Domains (1) summary
    PRK05477
    Location:62620
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB
  3. XM_036163041.1XP_036018934.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X3

    Conserved Domains (1) summary
    PRK05477
    Location:62575
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB
  4. XM_006501331.3XP_006501394.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X4

    Conserved Domains (1) summary
    PRK05477
    Location:62515
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB
  5. XM_036163042.1XP_036018935.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X5

    Related
    ENSMUSP00000103299.2, ENSMUST00000107672.8
    Conserved Domains (1) summary
    PRK05477
    Location:62510
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB
  6. XM_036163044.1XP_036018937.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X8

    Conserved Domains (1) summary
    PRK05477
    Location:54458
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB
  7. XM_036163043.1XP_036018936.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X7

    Conserved Domains (1) summary
    PRK05477
    Location:54503
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB
  8. XM_011240080.3XP_011238382.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X6

    Conserved Domains (1) summary
    PRK05477
    Location:54463
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

RNA

  1. XR_375512.3 RNA Sequence

  2. XR_004941305.1 RNA Sequence

  3. XR_003954307.1 RNA Sequence