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Tnk2 tyrosine kinase, non-receptor, 2 [ Mus musculus (house mouse) ]

Gene ID: 51789, updated on 5-Jan-2023

Summary

Official Symbol
Tnk2provided by MGI
Official Full Name
tyrosine kinase, non-receptor, 2provided by MGI
Primary source
MGI:MGI:1858308
See related
Ensembl:ENSMUSG00000022791 AllianceGenome:MGI:1858308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ack; Ack1; Pyk1; Ack-1; Cdgip
Summary
Enables WW domain binding activity. Involved in spermatid development. Located in several cellular components, including endosome; growth cone; and neuronal cell body. Is expressed in several structures, including alimentary system; liver; nervous system; retina; and vibrissa. Orthologous to human TNK2 (tyrosine kinase non receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 54.9), stomach adult (RPKM 35.9) and 27 other tissues See more
Orthologs
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Genomic context

See Tnk2 in Genome Data Viewer
Location:
16; 16 B3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32462699..32502311)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32644099..32683493)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene SET domain containing 6 pseudogene Neighboring gene transferrin receptor Neighboring gene tyrosine kinase, non-receptor 2, opposite strand Neighboring gene predicted gene, 34766 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC37479

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatid development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Grb2-EGFR complex ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoophidium ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
activated CDC42 kinase 1
Names
Cdc42 GTPase-inhibiting protein
P21cdc42Hs kinase
non-receptor protein tyrosine kinase ACK
tyrosine kinase non-receptor protein 2
NP_001103617.1
NP_001276372.1
NP_001334114.1
NP_058068.2
XP_006522395.1
XP_006522396.1
XP_006522397.1
XP_006522398.1
XP_006522399.1
XP_006522400.1
XP_006522401.1
XP_006522402.1
XP_006522403.1
XP_006522405.1
XP_006522406.1
XP_006522407.1
XP_011244248.1
XP_017172554.1
XP_017172555.1
XP_030105034.1
XP_030105035.1
XP_030105036.1
XP_036015894.1
XP_036015895.1
XP_036015896.1
XP_036015897.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110147.1NP_001103617.1  activated CDC42 kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001103617.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    BC052421
    Consensus CDS
    CCDS49828.1
    UniProtKB/Swiss-Prot
    O54967
    UniProtKB/TrEMBL
    A0A0R4J1L0
    Related
    ENSMUSP00000110778.2, ENSMUST00000115125.8
    Conserved Domains (7) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:126385
    STYKc; Protein kinase; unclassified specificity
    cd14328
    Location:959998
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:447514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  2. NM_001289443.1NP_001276372.1  activated CDC42 kinase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, lacks part of the 5' coding region, lacks two in-frame exons in the central coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC161755, BB583500, BC052421
    UniProtKB/Swiss-Prot
    O54967
    Conserved Domains (2) summary
    cd14328
    Location:469508
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    pfam11555
    Location:284348
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
  3. NM_001347185.1NP_001334114.1  activated CDC42 kinase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161755, BC052421
    Consensus CDS
    CCDS84224.1
    UniProtKB/Swiss-Prot
    O54967
    UniProtKB/TrEMBL
    D3Z3U7
    Related
    ENSMUSP00000110773.2, ENSMUST00000115120.9
  4. NM_016788.3NP_058068.2  activated CDC42 kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_058068.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161755, BQ770866, BU702226, DQ666696
    Consensus CDS
    CCDS37313.1
    UniProtKB/Swiss-Prot
    O54967
    UniProtKB/TrEMBL
    G3X9X7
    Related
    ENSMUSP00000110777.2, ENSMUST00000115124.9
    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:126385
    STYKc; Protein kinase; unclassified specificity
    cd14274
    Location:9761019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:447514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    32462699..32502311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317066.3XP_017172555.1  activated CDC42 kinase 1 isoform X14

    UniProtKB/TrEMBL
    D3Z3U6
    Related
    ENSMUSP00000110776.2, ENSMUST00000115123.9
    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:579957
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9611004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:447514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  2. XM_011245946.1XP_011244248.1  activated CDC42 kinase 1 isoform X18

    Conserved Domains (7) summary
    PHA03247
    Location:424802
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:806849
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:836875
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:1217
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:277344
    GTPase_binding; GTPase binding
    pfam11555
    Location:619683
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:225274
    SH3_9; Variant SH3 domain
  3. XM_030249176.1XP_030105036.1  activated CDC42 kinase 1 isoform X19

    Conserved Domains (6) summary
    PHA03247
    Location:424802
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:804843
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:1217
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:277344
    GTPase_binding; GTPase binding
    pfam11555
    Location:619683
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:225274
    SH3_9; Variant SH3 domain
  4. XM_006522335.1XP_006522398.1  activated CDC42 kinase 1 isoform X4

    Related
    ENSMUSP00000159113.2, ENSMUST00000238891.2
    Conserved Domains (8) summary
    cd09539
    Location:3091
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:618996
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:10001043
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10301069
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:471538
    GTPase_binding; GTPase binding
    pfam11555
    Location:813877
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419468
    SH3_9; Variant SH3 domain
  5. XM_030249174.2XP_030105034.1  activated CDC42 kinase 1 isoform X10

    Conserved Domains (8) summary
    cd09539
    Location:3091
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:603981
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9851028
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10151054
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:471538
    GTPase_binding; GTPase binding
    pfam11555
    Location:798862
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419468
    SH3_9; Variant SH3 domain
  6. XM_036160004.1XP_036015897.1  activated CDC42 kinase 1 isoform X17

    Conserved Domains (7) summary
    cd09539
    Location:3091
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:603981
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:9831022
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:473538
    GTPase_binding; GTPase binding
    pfam11555
    Location:798862
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419468
    SH3_9; Variant SH3 domain
  7. XM_036160001.1XP_036015894.1  activated CDC42 kinase 1 isoform X5

    Conserved Domains (8) summary
    cd09539
    Location:3091
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:618996
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:10001043
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10301069
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:473538
    GTPase_binding; GTPase binding
    pfam11555
    Location:813877
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419468
    SH3_9; Variant SH3 domain
  8. XM_006522339.1XP_006522402.1  activated CDC42 kinase 1 isoform X13

    Conserved Domains (7) summary
    cd09539
    Location:3091
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:618996
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:9981037
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:471538
    GTPase_binding; GTPase binding
    pfam11555
    Location:813877
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419468
    SH3_9; Variant SH3 domain
  9. XM_006522332.5XP_006522395.1  activated CDC42 kinase 1 isoform X1

    Conserved Domains (8) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:6261004
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:10081051
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10381077
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  10. XM_006522334.5XP_006522397.1  activated CDC42 kinase 1 isoform X3

    Conserved Domains (8) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:6261016
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:10051049
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10361075
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  11. XM_006522338.5XP_006522401.1  activated CDC42 kinase 1 isoform X11

    Conserved Domains (7) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:6261004
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  12. XM_006522336.5XP_006522399.1  activated CDC42 kinase 1 isoform X6

    UniProtKB/TrEMBL
    A0A5F8MPC4
    Related
    ENSMUSP00000158905.2, ENSMUST00000238856.2
    Conserved Domains (8) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:611989
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9931036
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10231062
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  13. XM_036160002.1XP_036015895.1  activated CDC42 kinase 1 isoform X8

    Conserved Domains (8) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:6111001
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9901034
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10211060
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:481546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  14. XM_030249175.2XP_030105035.1  activated CDC42 kinase 1 isoform X15

    UniProtKB/TrEMBL
    A0A5F8MPM0
    Related
    ENSMUSP00000159023.2, ENSMUST00000238806.2
    Conserved Domains (7) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:611989
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  15. XM_006522333.5XP_006522396.1  activated CDC42 kinase 1 isoform X2

    Conserved Domains (8) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:6261004
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:10081051
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10381077
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  16. XM_036160003.1XP_036015896.1  activated CDC42 kinase 1 isoform X12

    Conserved Domains (7) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:6261004
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:481546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  17. XM_017317065.3XP_017172554.1  activated CDC42 kinase 1 isoform X7

    Conserved Domains (8) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:611989
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9931036
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10231062
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  18. XM_006522337.5XP_006522400.1  activated CDC42 kinase 1 isoform X9

    Conserved Domains (8) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:6111001
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9901034
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10211060
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  19. XM_006522340.5XP_006522403.1  activated CDC42 kinase 1 isoform X16

    Conserved Domains (7) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:611989
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  20. XM_006522342.5XP_006522405.1  activated CDC42 kinase 1 isoform X20

    Conserved Domains (6) summary
    PHA03247
    Location:186565
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:568611
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:598637
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    pfam09027
    Location:39106
    GTPase_binding; GTPase binding
    pfam11555
    Location:381445
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cl17036
    Location:636
    SH3; Src Homology 3 domain superfamily
  21. XM_006522344.1XP_006522407.1  activated CDC42 kinase 1 isoform X21

    See identical proteins and their annotated locations for XP_006522407.1

    Conserved Domains (5) summary
    PHA03247
    Location:104483
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:486529
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:516555
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    pfam09027
    Location:124
    GTPase_binding; GTPase binding
    pfam11555
    Location:299363
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
  22. XM_006522343.1XP_006522406.1  activated CDC42 kinase 1 isoform X21

    See identical proteins and their annotated locations for XP_006522406.1

    Conserved Domains (5) summary
    PHA03247
    Location:104483
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:486529
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:516555
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    pfam09027
    Location:124
    GTPase_binding; GTPase binding
    pfam11555
    Location:299363
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6