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TNK2 tyrosine kinase non receptor 2 [ Homo sapiens (human) ]

Gene ID: 10188, updated on 5-Jan-2022

Summary

Official Symbol
TNK2provided by HGNC
Official Full Name
tyrosine kinase non receptor 2provided by HGNC
Primary source
HGNC:HGNC:19297
See related
Ensembl:ENSG00000061938 MIM:606994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACK; ACK1; ACK-1; p21cdc42Hs
Summary
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 21.9), bone marrow (RPKM 14.7) and 24 other tissues See more
Orthologs
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Genomic context

See TNK2 in Genome Data Viewer
Location:
3q29
Exon count:
28
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (195863364..195908551, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195590235..195635422, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mucin 4, cell surface associated Neighboring gene Sharpr-MPRA regulatory region 430 Neighboring gene uncharacterized LOC107984010 Neighboring gene long intergenic non-protein coding RNA 1983 Neighboring gene kinesin family member 3A pseudogene 1 Neighboring gene microRNA 6829 Neighboring gene TNK2 antisense RNA 1 Neighboring gene serine/threonine-protein phosphatase 4 regulatory subunit 2-like Neighboring gene RNA, U2 small nuclear 11, pseudogene Neighboring gene mucin-5AC-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44758, FLJ45547

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
enables WW domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Grb2-EGFR complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoophidium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
activated CDC42 kinase 1
Names
activated Cdc42-associated kinase 1
activated p21cdc42Hs kinase
tyrosine kinase non-receptor protein 2
NP_001010938.2
NP_001294975.1
NP_001369200.1
NP_001369201.1
NP_001369202.1
NP_001369203.1
NP_001369204.1
NP_001373093.1
NP_001374636.1
NP_001374637.1
NP_001374638.1
NP_001374639.1
NP_001374640.1
NP_001374641.1
NP_001374642.1
NP_001374643.1
NP_001374644.1
NP_001374645.1
NP_001374646.1
NP_001374647.1
NP_001374648.1
NP_001374649.1
NP_001374650.1
NP_005772.3
XP_005269331.1
XP_005269332.1
XP_011510619.1
XP_011510620.2
XP_011510623.1
XP_016860998.1
XP_024309059.1
XP_024309060.1
XP_024309061.1
XP_024309062.1
XP_024309063.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029779.1 RefSeqGene

    Range
    5001..50645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001010938.2NP_001010938.2  activated CDC42 kinase 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct 5' UTR and 5' coding region, lacks one alternate 3' coding exon, and contains a different alternate 3' coding exon, as compared to variant 1. The translation remains in-frame, and results in a longer isoform (2) that has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK127455, AK131539, BC020395, L13738
    Consensus CDS
    CCDS33927.1
    Related
    ENSP00000499858.1, ENST00000671753.1
    Conserved Domains (7) summary
    cd09539
    Location:3091
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:582888
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:9981037
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam14604
    Location:419468
    SH3_9; Variant SH3 domain
    pfam09027
    Location:471538
    GTPase_binding; GTPase binding
    pfam11555
    Location:813877
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
  2. NM_001308046.2NP_001294975.1  activated CDC42 kinase 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate 5' exon, contains an alternate 5' terminal exon, lacks one alternate 3' coding exon, and initiates translation at an alternate start codon, compared to variant 1. It encodes a shorter isoform (3) that has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS77875.1
    UniProtKB/Swiss-Prot
    Q07912
    UniProtKB/TrEMBL
    C9J1X3
    Related
    ENSP00000392546.1, ENST00000428187.7
    Conserved Domains (7) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:158417
    STYKc; Protein kinase; unclassified specificity
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  3. NM_001382271.1NP_001369200.1  activated CDC42 kinase 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Related
    ENSP00000503221.1, ENST00000678220.1
    Conserved Domains (8) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:575881
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9931036
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10231062
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:481546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  4. NM_001382272.1NP_001369201.1  activated CDC42 kinase 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (8) summary
    cd09539
    Location:3091
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:582888
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:10001043
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10301069
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:473538
    GTPase_binding; GTPase binding
    pfam11555
    Location:813877
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419468
    SH3_9; Variant SH3 domain
  5. NM_001382273.1NP_001369202.1  activated CDC42 kinase 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Related
    ENSP00000499899.1, ENST00000672887.2
    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558864
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9761019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  6. NM_001382274.1NP_001369203.1  activated CDC42 kinase 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558864
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9761019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  7. NM_001382275.1NP_001369204.1  activated CDC42 kinase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (7) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:590896
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:481546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  8. NM_001386164.1NP_001373093.1  activated CDC42 kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Related
    ENSP00000500887.1, ENST00000673420.1
    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9611004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  9. NM_001387707.1NP_001374636.1  activated CDC42 kinase 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (8) summary
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:590896
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:10081051
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10381077
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:481546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
  10. NM_001387708.1NP_001374637.1  activated CDC42 kinase 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (8) summary
    cd09539
    Location:3091
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:567873
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9851028
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10151054
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:473538
    GTPase_binding; GTPase binding
    pfam11555
    Location:798862
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419468
    SH3_9; Variant SH3 domain
  11. NM_001387709.1NP_001374638.1  activated CDC42 kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9611004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  12. NM_001387710.1NP_001374639.1  activated CDC42 kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9611004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  13. NM_001387711.1NP_001374640.1  activated CDC42 kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9611004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  14. NM_001387712.1NP_001374641.1  activated CDC42 kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9611004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  15. NM_001387713.1NP_001374642.1  activated CDC42 kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9581002
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:9891028
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  16. NM_001387714.1NP_001374643.1  activated CDC42 kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9581002
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:9891028
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  17. NM_001387715.1NP_001374644.1  activated CDC42 kinase 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (7) summary
    cd09539
    Location:3091
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:567873
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:9831022
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:473538
    GTPase_binding; GTPase binding
    pfam11555
    Location:798862
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419468
    SH3_9; Variant SH3 domain
  18. NM_001387716.1NP_001374645.1  activated CDC42 kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (7) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558864
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:9741013
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  19. NM_001387717.1NP_001374646.1  activated CDC42 kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (7) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558864
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:9741013
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  20. NM_001387718.1NP_001374647.1  activated CDC42 kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (7) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558864
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:9741013
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  21. NM_001387719.1NP_001374648.1  activated CDC42 kinase 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (7) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543849
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:959998
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  22. NM_001387720.1NP_001374649.1  activated CDC42 kinase 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Related
    ENSP00000500486.1, ENST00000672024.1
    Conserved Domains (7) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543849
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:959998
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  23. NM_001387721.1NP_001374650.1  activated CDC42 kinase 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Conserved Domains (7) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543849
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:959998
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  24. NM_005781.5NP_005772.3  activated CDC42 kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_005772.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the more frequently occurring transcript and it encodes isoform 1.
    Source sequence(s)
    AC124944, AK127455, AK131539, BG742978, CN411136, L13738
    Consensus CDS
    CCDS33928.1
    UniProtKB/Swiss-Prot
    Q07912
    UniProtKB/TrEMBL
    B3KXJ4
    Related
    ENSP00000329425.6, ENST00000333602.14
    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9581002
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:9891028
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain

RNA

  1. NR_170678.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  2. NR_170679.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  3. NR_170680.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  4. NR_170681.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  5. NR_170682.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  6. NR_170683.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  7. NR_170684.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  8. NR_170685.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  9. NR_170686.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  10. NR_170687.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  11. NR_170688.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  12. NR_170689.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  13. NR_170690.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  14. NR_170691.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944
  15. NR_170692.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    195863364..195908551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453292.1XP_024309060.1  activated CDC42 kinase 1 isoform X8

    Conserved Domains (6) summary
    cd09539
    Location:2384
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:410461
    SH3; Src homology 3 domains
    PHA03247
    Location:575881
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9931036
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10231062
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:147404
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  2. XM_024453295.1XP_024309063.1  activated CDC42 kinase 1 isoform X9

    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558864
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9761019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  3. XM_024453291.1XP_024309059.1  activated CDC42 kinase 1 isoform X6

    Conserved Domains (8) summary
    cd09539
    Location:70131
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:10401083
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10701109
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:194451
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam14604
    Location:459508
    SH3_9; Variant SH3 domain
    pfam09027
    Location:511578
    GTPase_binding; GTPase binding
    pfam11555
    Location:853917
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cl26464
    Location:622928
    Atrophin-1; Atrophin-1 family
  4. XM_011512317.3XP_011510619.1  activated CDC42 kinase 1 isoform X1

    Conserved Domains (8) summary
    cd09539
    Location:170231
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:290549
    STYKc; Protein kinase; unclassified specificity
    cd14274
    Location:11401183
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:11701209
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:294551
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:611678
    GTPase_binding; GTPase binding
    pfam11555
    Location:9531017
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:559608
    SH3_9; Variant SH3 domain
  5. XM_005269275.3XP_005269332.1  activated CDC42 kinase 1 isoform X12

    Conserved Domains (6) summary
    cd14274
    Location:662705
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:692731
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    pfam09027
    Location:133200
    GTPase_binding; GTPase binding
    pfam11555
    Location:475539
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:81130
    SH3_9; Variant SH3 domain
    cl21453
    Location:173
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011512318.2XP_011510620.2  activated CDC42 kinase 1 isoform X2

  7. XM_024453293.1XP_024309061.1  activated CDC42 kinase 1 isoform X9

    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558864
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9761019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  8. XM_024453294.1XP_024309062.1  activated CDC42 kinase 1 isoform X9

    Conserved Domains (8) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558864
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:9761019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
  9. XM_011512321.2XP_011510623.1  activated CDC42 kinase 1 isoform X10

    Conserved Domains (7) summary
    smart00221
    Location:50309
    STYKc; Protein kinase; unclassified specificity
    cd14274
    Location:900943
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:930969
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:54311
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:371438
    GTPase_binding; GTPase binding
    pfam11555
    Location:713777
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:319368
    SH3_9; Variant SH3 domain
  10. XM_005269274.3XP_005269331.1  activated CDC42 kinase 1 isoform X11

    Conserved Domains (6) summary
    cd14274
    Location:737780
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:767806
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    pfam09027
    Location:208275
    GTPase_binding; GTPase binding
    pfam11555
    Location:550614
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:156205
    SH3_9; Variant SH3 domain
    cl21453
    Location:1148
    PKc_like; Protein Kinases, catalytic domain
  11. XM_017005509.1XP_016860998.1  activated CDC42 kinase 1 isoform X4

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