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STK26 serine/threonine kinase 26 [ Homo sapiens (human) ]

Gene ID: 51765, updated on 12-Aug-2018

Summary

Official Symbol
STK26provided by HGNC
Official Full Name
serine/threonine kinase 26provided by HGNC
Primary source
HGNC:HGNC:18174
See related
Ensembl:ENSG00000134602 MIM:300547; Vega:OTTHUMG00000022420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MASK; MST4
Summary
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 22.0), bone marrow (RPKM 21.7) and 22 other tissues See more
Orthologs

Genomic context

See STK26 in Genome Data Viewer
Location:
Xq26.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (132023217..132075943)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (131157245..131209971)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene firre intergenic repeating RNA element Neighboring gene PNKD pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 514 Neighboring gene FERM domain containing 7 Neighboring gene acylglycerol kinase pseudogene Neighboring gene RAP2C antisense RNA 1 Neighboring gene RAP2C, member of RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
    Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
  • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
    Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
  • LKB1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    LKB1 signaling events, organism-specific biosystem
    LKB1 signaling events
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
activation of MAPKKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
microvillus assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of hydrogen peroxide-induced cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi-associated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
vesicle membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 26
Names
Mst3 and SOK1-related kinase
STE20-like kinase 4
STE20-like kinase MST4
mammalian Ste20-like protein kinase 4
mammalian sterile 20-like 4
serine/threonine protein kinase 26
serine/threonine protein kinase MST4
serine/threonine-protein kinase MASK
NP_001035917.1
NP_001035918.1
NP_057626.2
XP_011529651.1
XP_011529652.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029562.1 RefSeqGene

    Range
    5001..57727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042452.1NP_001035917.1  serine/threonine-protein kinase 26 isoform 3

    See identical proteins and their annotated locations for NP_001035917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) is shorter compared to isoform 1, and lacks kinase activity.
    Source sequence(s)
    AF344883, BC070056
    Consensus CDS
    CCDS43995.1
    UniProtKB/Swiss-Prot
    Q9P289
    Related
    ENSP00000419702.1, OTTHUMP00000215131, ENST00000496850.1, OTTHUMT00000355065
    Conserved Domains (1) summary
    cl21453
    Location:19233
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001042453.1NP_001035918.1  serine/threonine-protein kinase 26 isoform 2

    See identical proteins and their annotated locations for NP_001035918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AK075107, BC070056, DA760264
    Consensus CDS
    CCDS48168.1
    UniProtKB/Swiss-Prot
    Q9P289
    Related
    ENSP00000377868.2, OTTHUMP00000215133, ENST00000394335.6, OTTHUMT00000355067
    Conserved Domains (1) summary
    cl21453
    Location:15218
    PKc_like; Protein Kinases, catalytic domain
  3. NM_016542.3NP_057626.2  serine/threonine-protein kinase 26 isoform 1

    See identical proteins and their annotated locations for NP_057626.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF231012, BC070056, DA760264
    Consensus CDS
    CCDS14631.1
    UniProtKB/Swiss-Prot
    Q9P289
    Related
    ENSP00000377867.2, OTTHUMP00000024034, ENST00000394334.6, OTTHUMT00000058306
    Conserved Domains (1) summary
    cd06640
    Location:19295
    STKc_MST4; Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    132023217..132075943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531350.1XP_011529652.1  serine/threonine-protein kinase 26 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:13175
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:12196
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011531349.1XP_011529651.1  serine/threonine-protein kinase 26 isoform X1

    See identical proteins and their annotated locations for XP_011529651.1

    Conserved Domains (1) summary
    cl21453
    Location:1197
    PKc_like; Protein Kinases, catalytic domain
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