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Stk26 serine/threonine kinase 26 [ Mus musculus (house mouse) ]

Gene ID: 70415, updated on 8-Feb-2024

Summary

Official Symbol
Stk26provided by MGI
Official Full Name
serine/threonine kinase 26provided by MGI
Primary source
MGI:MGI:1917665
See related
Ensembl:ENSMUSG00000031112 AllianceGenome:MGI:1917665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mst4; 2610018G03Rik
Summary
Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including microvillus assembly; regulation of hydrogen peroxide-induced cell death; and response to hydrogen peroxide. Predicted to act upstream of or within apoptotic process and phosphorylation. Predicted to be located in several cellular components, including Golgi membrane; Golgi-associated vesicle; and apical plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human STK26 (serine/threonine kinase 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 10.5), thymus adult (RPKM 5.6) and 17 other tissues See more
Orthologs
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Genomic context

See Stk26 in Genome Data Viewer
Location:
X A5; X 27.5 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (49930052..49981980)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (50841174..50893103)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47143 Neighboring gene predicted gene, 35612 Neighboring gene predicted gene 14620 Neighboring gene STARR-seq mESC enhancer starr_47144 Neighboring gene STARR-seq mESC enhancer starr_47145 Neighboring gene STARR-seq mESC enhancer starr_47146 Neighboring gene STARR-seq mESC enhancer starr_47148 Neighboring gene STARR-seq mESC enhancer starr_47149 Neighboring gene functional intergenic repeating RNA element Neighboring gene STARR-seq mESC enhancer starr_47152 Neighboring gene STARR-seq mESC enhancer starr_47153 Neighboring gene STARR-seq mESC enhancer starr_47154 Neighboring gene STARR-seq mESC enhancer starr_47158 Neighboring gene FERM domain containing 7 Neighboring gene STARR-seq mESC enhancer starr_47159 Neighboring gene 40S ribosomal protein S29 pseudogene Neighboring gene RAP2C, member of RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated protein kinase signaling cascade ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 26
Names
Mst3 and SOK1-related kinase
STE20-like kinase MST4
mammalian STE20-like protein kinase 4
serine/threonine-protein kinase MST4
NP_001300673.1
NP_598490.1
XP_017174107.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313744.2NP_001300673.1  serine/threonine-protein kinase 26 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL670230, AL671907
    UniProtKB/TrEMBL
    A2AD84
    Conserved Domains (2) summary
    cd06640
    Location:19295
    STKc_MST4; Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4
    smart00220
    Location:24274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. NM_133729.3NP_598490.1  serine/threonine-protein kinase 26 isoform 1

    See identical proteins and their annotated locations for NP_598490.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL670230, AL671907
    Consensus CDS
    CCDS40968.1
    UniProtKB/Swiss-Prot
    Q99JT2
    UniProtKB/TrEMBL
    A2AD84, A2AD85
    Related
    ENSMUSP00000033444.5, ENSMUST00000033444.11
    Conserved Domains (2) summary
    cd06640
    Location:19295
    STKc_MST4; Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4
    smart00220
    Location:24274
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    49930052..49981980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318618.2XP_017174107.1  serine/threonine-protein kinase 26 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:15218
    PKc_like; Protein Kinases, catalytic domain